INT72334

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.71
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (LRP5) plasma membrane (LRP5)
Anatomy Link Frequency
photoreceptor 1
OPS 1
LRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 15 99.92 Very High Very High Very High
Neurotransmitter 5 97.20 Very High Very High Very High
cytokine 8 96.82 Very High Very High Very High
Inflammation 6 96.62 Very High Very High Very High
Morphine 4 94.48 High High
long-term potentiation 5 88.24 High High
Pyramidal cell 1 86.40 High High
headache 3 31.12 Quite Low
Nicotine 2 26.96 Quite Low
depression 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 96.62 Very High Very High Very High
Mental Disorders 35 96.36 Very High Very High Very High
Osteoporosis 15 95.02 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 92.10 High High
Congenital Anomalies 31 88.24 High High
Drug Induced Neurotoxicity 84 82.64 Quite High
Disease 34 78.56 Quite High
Infection 32 76.28 Quite High
Retinal Dystrophies 14 69.04 Quite High
Blindness 8 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following this, the source population of the OHS is large enough to recruit the required number of OPs and employees according to the sample size calculation.


Negative_regulation (number) of OPs
1) Confidence 0.35 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2841673 Disease Relevance 0.10 Pain Relevance 0
Several of the HIV protease inhibitors have been shown to alter bone mineral density.50 Recent gene expression profiling has indicated that exposure of osteoblastic cells to nelfinavir and ritonavir increases gene expression of the inflammatory cytokines, MCP-1, and interleukin-8.51 Protease inhibitors have also been suggested to inhibit 1-alpha-hydroxylase, as well as to reduce 1,25(OH)2D levels, which could reduce bone mineral density.45 LRP5, a positive regulator of bone formation, is inhibited by protease inhibitors.51,52
Negative_regulation (reduce) of LRP5 associated with inflammation, acquired immune deficiency syndrome or hiv infection, osteoporosis and cytokine
2) Confidence 0.31 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.86 Pain Relevance 0.12
There was also significant decrease in OPS delay.
Negative_regulation (decrease) of OPS in OPS
3) Confidence 0.30 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374279 Disease Relevance 0 Pain Relevance 0.56
Most of the compounds were cholinesterase inhibitors (19 OPs and 3 carbamates).
Negative_regulation (inhibitors) of OPs
4) Confidence 0.27 Published 2010 Journal Environ Health Section Body Doc Link PMC2931486 Disease Relevance 0 Pain Relevance 0
OPs containing a P = O moiety are effective inhibitors of AChE, whereas OPs with a P = S moiety require bioactivation to form an "oxon" or oxygen analogue of the parent compound.
Negative_regulation (inhibitors) of OPs
5) Confidence 0.23 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 0.16 Pain Relevance 0.13
The lack of OPs in the rge chick ERG suggests that there could be an abnormality of inner retinal cells or the circuitry feeding into those cells.
Negative_regulation (lack) of OPs
6) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652020 Disease Relevance 0.17 Pain Relevance 0
This association does not appear to occur in chicks with form deprivation or defocus, although one study found a reduction in OPs [36] and another study found an increase in cone photoreceptor sensitivity [37].
Negative_regulation (reduction) of OPs in photoreceptor
7) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652020 Disease Relevance 0.43 Pain Relevance 0

General Comments

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