INT72336

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 7
Total Number 11
Disease Relevance 3.09
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
seminal vesicles 2
brain 2
DRN 2
dorsal 1
spinal cord 1
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 22 100.00 Very High Very High Very High
Serotonin 20 99.96 Very High Very High Very High
Raphe 15 99.62 Very High Very High Very High
Periaqueductal grey 165 98.48 Very High Very High Very High
Spinal cord 10 98.36 Very High Very High Very High
midbrain 27 97.72 Very High Very High Very High
Central grey 6 97.56 Very High Very High Very High
fluoxetine 29 97.16 Very High Very High Very High
monoamine 3 96.04 Very High Very High Very High
Pain 30 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.88 Very High Very High Very High
Urological Neuroanatomy 171 98.48 Very High Very High Very High
Pain 30 95.04 Very High Very High Very High
Nociception 7 91.68 High High
Neuropathic Pain 4 85.00 Quite High
Hyperalgesia 6 84.60 Quite High
Depression 3 75.60 Quite High
Inflammatory Pain 2 75.00 Quite High
Morphine Dependence 1 25.00 Low Low
Headache 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both male and female rats expressed mRNA for 5-HT1A, B, D and F receptors.
Transcription (expressed) of 5-HT1A
1) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.26 Pain Relevance 0.52
The present study examined the distribution of [3H]8-OH-DPAT-labeled 5-HT1A receptors and their degree of coupling to G proteins in the hypothalamus and several other brain regions.
Spec (examined) Transcription (distribution) of 5-HT1A in brain
2) Confidence 0.67 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374282 Disease Relevance 0 Pain Relevance 0.23
It is also consistent with prior studies which have reported that 5-HT1A levels within the PAG are relatively low compared to the adjacent dorsal raphe nucleus, and that 5-HT1A and 5-HT1B receptors are largely expressed within postsynaptic and presynaptic elements within the midbrain, respectively [43,44].
Transcription (expressed) of 5-HT1A in midbrain associated with periaqueductal grey, midbrain and raphe
3) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.35 Pain Relevance 0.91
The sensitivity of 5-HT1A serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) modulating brain monoamine synthesis was investigated in rats during morphine treatment and after naloxone-precipitated withdrawal.
Spec (investigated) Transcription (sensitivity) of 5-HT1A in brain associated with narcan, withdrawal, serotonin, morphine and monoamine
4) Confidence 0.67 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11882917 Disease Relevance 0 Pain Relevance 0.55
No significant difference was observed in the relative expression levels of 5-HT1A receptor mRNA in seminal vesicles and in the vasa deferentia.
Transcription (expression) of 5-HT1A in seminal vesicles
5) Confidence 0.52 Published 2004 Journal J. Androl. Section Abstract Doc Link 15477361 Disease Relevance 0 Pain Relevance 0.48
No significant difference was observed in the relative expression levels of 5-HT1A receptor mRNA in seminal vesicles and in the vasa deferentia.
Transcription (levels) of 5-HT1A in seminal vesicles
6) Confidence 0.52 Published 2004 Journal J. Androl. Section Abstract Doc Link 15477361 Disease Relevance 0 Pain Relevance 0.48
Here we showed that 1 or 4 h after a subcutaneous bee venom challenge, expression of 5-HT1A receptor mRNA in the ipsilateral lumbar spinal cord increased significantly by 80.94 or 37.86%, respectively.
Transcription (expression) of 5-HT1A in spinal cord associated with spinal cord
7) Confidence 0.52 Published 2003 Journal Pain Section Abstract Doc Link 14581120 Disease Relevance 0.94 Pain Relevance 0.93
Following carrageenan inflammation, the expression of 5-HT1A receptor mRNA in the DRN and bilateral vlPAG neurons was significantly increased.
Transcription (expression) of 5-HT1A in DRN associated with inflammation
8) Confidence 0.52 Published 2000 Journal Neuroreport Section Abstract Doc Link 11059903 Disease Relevance 0.42 Pain Relevance 0.33
Expression of 5-HT1A receptor mRNA in rat dorsal raphe nucleus and ventrolateral periaqueductal gray neurons after peripheral inflammation.
Transcription (Expression) of 5-HT1A in dorsal associated with inflammation, central grey and raphe
9) Confidence 0.52 Published 2000 Journal Neuroreport Section Title Doc Link 11059903 Disease Relevance 0.42 Pain Relevance 0.44
The findings of this study demonstrated that 5-HT1A receptor mRNA was expressed with moderate to high level in the DRN and vlPAG neurons.
Transcription (expressed) of 5-HT1A in DRN
10) Confidence 0.52 Published 2000 Journal Neuroreport Section Abstract Doc Link 11059903 Disease Relevance 0.41 Pain Relevance 0.32
These findings are consistent with the detection of mRNA for each of 5-HT1A, 5-HT1B and 5-HT1D receptors in the present study in both male and female rats, although the present study was not designed to examine quantitative gender related differences.
Transcription (detection) of 5-HT1A
11) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.28 Pain Relevance 0.43

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