INT72337

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 37
Total Number 41
Disease Relevance 17.02
Pain Relevance 8.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
monocyte 6
liver 4
platelet 4
nociceptors 4
blood 4
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 8 99.98 Very High Very High Very High
Inflammation 289 99.84 Very High Very High Very High
Thoracotomy 46 99.72 Very High Very High Very High
Rostral ventrolateral medulla 21 99.64 Very High Very High Very High
cytokine 104 99.52 Very High Very High Very High
ischemia 55 99.50 Very High Very High Very High
alcohol 82 98.44 Very High Very High Very High
intrathecal 2 98.12 Very High Very High Very High
Inflammatory mediators 31 97.68 Very High Very High Very High
nociceptor 2 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 8 99.98 Very High Very High Very High
INFLAMMATION 339 99.84 Very High Very High Very High
Cv General 4 Under Development 12 99.84 Very High Very High Very High
Sepsis 14 99.64 Very High Very High Very High
Disease 114 99.60 Very High Very High Very High
Stress 54 99.56 Very High Very High Very High
Infection 41 99.36 Very High Very High Very High
Alzheimer's Dementia 15 98.16 Very High Very High Very High
Hepatotoxicity 13 97.76 Very High Very High Very High
Trypanosomiasis 1 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal (i.t.) administration of IL-1beta activates p38 mitogen-activated protein kinase (MAPK), and leads to induction of inducible nitric oxide synthase (iNOS) and release of nitric oxide (NO), which sensitizes the spinal nociceptors and produces thermal hyperalgesia and allodynia.
Positive_regulation (leads) of Positive_regulation (induction) of iNOS in nociceptors associated with allodynia, thermal hyperalgesia, nociceptor and intrathecal
1) Confidence 0.65 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.68 Pain Relevance 0.85
Pharmacokinetic analysis of the residence time of AMG in the different areas of the gastrointestinal tract, revealed that AMG remains in the gastrointestinal tract at least for 4 hr, the time necessary for a maximal induction of NOS2 and for maximal protection against ethanol-induced damage.
Positive_regulation (necessary) of Positive_regulation (induction) of NOS2
2) Confidence 0.58 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10219827 Disease Relevance 0.17 Pain Relevance 0.04
We evaluated the contribution of peroxynitrite to the fatal cardiovascular depression induced by overproduction of nitric oxide (NO) after activation of inducible NO synthase (iNOS) in the rostral ventrolateral medulla (RVLM), the origin of sympathetic vasomotor tone.
Positive_regulation (induced) of Positive_regulation (activation) of inducible NO synthase in sympathetic associated with rostral ventrolateral medulla, depression and cardiovascular disorder under development
3) Confidence 0.50 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384174 Disease Relevance 0.33 Pain Relevance 0.41
We evaluated the contribution of peroxynitrite to the fatal cardiovascular depression induced by overproduction of nitric oxide (NO) after activation of inducible NO synthase (iNOS) in the rostral ventrolateral medulla (RVLM), the origin of sympathetic vasomotor tone.
Positive_regulation (induced) of Positive_regulation (activation) of iNOS in sympathetic associated with rostral ventrolateral medulla, depression and cardiovascular disorder under development
4) Confidence 0.50 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384174 Disease Relevance 0.33 Pain Relevance 0.42
Increased nitrite production was accompanied by increased NOS2 catalytic activity, steady state mRNA levels, and promoter activation.
Positive_regulation (accompanied) of Positive_regulation (increased) of NOS2
5) Confidence 0.50 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.17 Pain Relevance 0.42
The induction in vitro of inducible nitric oxide synthase (iNOS) in intact gastric circular (CM) and longitudinal (LM) smooth muscle preparations was evaluated 1) pharmacologically, by the appearance of 1 mM L-arginine (L-Arg)-induced relaxation in a precontracted tissue; 2) biochemically, according to the appearance of iNOS mRNA using a reverse transcriptase-polymerase chain reaction; and 3) immunohistochemically, using an iNOS-specific antibody.
Positive_regulation (induction) of Positive_regulation (inducible) of iNOS in smooth muscle
6) Confidence 0.50 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374708 Disease Relevance 0 Pain Relevance 0
The oxidative stress proteins inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) are upregulated in the liver during sepsis but have opposite roles.
Positive_regulation (upregulated) of Positive_regulation (inducible) of iNOS in liver associated with stress and sepsis
7) Confidence 0.50 Published 2005 Journal J Trauma Section Abstract Doc Link 15824646 Disease Relevance 0.73 Pain Relevance 0.34
Immunoblotting analysis revealed that lipopolysaccharide increased the protein level of inducible nitric oxide synthase (iNOS).
Positive_regulation (increased) of Positive_regulation (increased) of iNOS
8) Confidence 0.49 Published 2003 Journal Arch. Toxicol. Section Abstract Doc Link 12851743 Disease Relevance 0.09 Pain Relevance 0.07
Intrathecal (i.t.) administration of IL-1beta activates p38 mitogen-activated protein kinase (MAPK), and leads to induction of inducible nitric oxide synthase (iNOS) and release of nitric oxide (NO), which sensitizes the spinal nociceptors and produces thermal hyperalgesia and allodynia.
Positive_regulation (induction) of Positive_regulation (inducible) of iNOS in nociceptors associated with allodynia, thermal hyperalgesia, nociceptor and intrathecal
9) Confidence 0.47 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.68 Pain Relevance 0.85
METHODS AND RESULTS: Subcutaneously administered indomethacin (10 mg/kg) provoked ulceration in the small intestine, mainly the jejunum and ileum, accompanied by increases in myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) activities as well as the enterobacterial numbers invading the mucosa.
Positive_regulation (increases) of Positive_regulation (inducible) of iNOS in jejunum
10) Confidence 0.46 Published 2000 Journal Digestion Section Body Doc Link 10671773 Disease Relevance 0.09 Pain Relevance 0
In addition, the interaction of repeated opening and closing of alveoli and LPS was found to increase iNOS expression, and an iNOS inhibitor attenuated accumulation of inflammatory cells in the lungs and restored blood gases.
Positive_regulation (increase) of Positive_regulation (accumulation) of iNOS in blood associated with inflammation and thoracotomy
11) Confidence 0.44 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526521 Disease Relevance 1.46 Pain Relevance 0.22
The oxidative stress proteins inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) are upregulated in the liver during sepsis but have opposite roles.
Positive_regulation (upregulated) of Positive_regulation (upregulated) of inducible nitric oxide synthase in liver associated with stress and sepsis
12) Confidence 0.43 Published 2005 Journal J Trauma Section Abstract Doc Link 15824646 Disease Relevance 0.73 Pain Relevance 0.34
Immunoblotting analysis revealed that lipopolysaccharide increased the protein level of inducible nitric oxide synthase (iNOS).
Positive_regulation (increased) of Positive_regulation (increased) of inducible nitric oxide synthase
13) Confidence 0.43 Published 2003 Journal Arch. Toxicol. Section Abstract Doc Link 12851743 Disease Relevance 0.09 Pain Relevance 0.07
RESULTS: Pre- or posttreatment with C-PC (30 or 50 mg/kg, IP) significantly attenuated carrageenan-induced inflammatory nociception and the induction of iNOS and COX-2 at the late phase, (4 h) accompanied by an inhibition of the formation of TNF-alpha, prostaglandin E(2), nitrate and myeloperoxidase activity.
Positive_regulation (induced) of Positive_regulation (induction) of iNOS
14) Confidence 0.43 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299804 Disease Relevance 0.16 Pain Relevance 0
RESULTS: Indomethacin caused hemorrhagic lesions in the small intestine, accompanied with an increase in intestinal motility, bacterial invasion and inducible nitric oxide synthase (iNOS) activity, as well as the expression of COX-2 mRNA in the mucosa.
Positive_regulation (increase) of Positive_regulation (inducible) of iNOS in small intestine
15) Confidence 0.41 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15610444 Disease Relevance 0 Pain Relevance 0
Messages for IL-6, iNOS and MCP-1 were significantly increased as a result of infection.
Positive_regulation (increased) of Positive_regulation (Messages) of iNOS associated with infection
16) Confidence 0.40 Published 2002 Journal Acta Otolaryngol. Section Abstract Doc Link 12030571 Disease Relevance 0.48 Pain Relevance 0.33
Using isoflurane as a representative anesthetic, the present study tested the hypothesis that NO released after anesthetic-induced preconditioning initiates delayed cardioprotection via activation of nuclear transcription factor-kappaB (NF-kappaB), leading to myocardial adaptation by upregulation of iNOS and increase in production of NO.
Positive_regulation (upregulation) of Positive_regulation (increase) of iNOS associated with isoflurane
17) Confidence 0.40 Published 2008 Journal Shock Section Abstract Doc Link 18708911 Disease Relevance 0.24 Pain Relevance 0.25
The salient findings of the study are: 1- Genetic modification of MSCs with Shh transgene results in multifold increased iNOS upregulation and NO production, an effect which was associated with higher level of angiogenic growth factor expression including VEGF, Ang-1 and netrin-1. 2- The induction of iNOS in ShhMSCs occurred in PKC dependent manner. 3- ShhCM mediated increased angiogenic response was abrogated in the presence of Shh and netrin-1 specific antibodies. 4- Intramyocardial engraftment of ShhMSC induced significant angiogenesis, improved regional blood flow and significantly preserved global heart function.
Positive_regulation (increased) of Positive_regulation (upregulation) of iNOS in blood
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.09 Pain Relevance 0
We reported recently that an upregulation of the inducible nitric oxide synthase (iNOS) in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located, is a crucial determinant for the elicitation of cardiovascular depression during experimental endotoxemia.
Positive_regulation (upregulation) of Positive_regulation (upregulation) of iNOS in medulla associated with endotoxemia, rostral ventrolateral medulla, depression and cardiovascular disorder under development
19) Confidence 0.36 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.26 Pain Relevance 0.28
In contrast, the third NOS isoform, inducible NOS (iNOS), is not expressed in normal tissues and may be induced by diverse cytokines or endotoxins, triggering extended production of larger (nanomole) amounts of NO [44].
Positive_regulation (induced) of Positive_regulation (inducible) of iNOS associated with cytokine
20) Confidence 0.36 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.88 Pain Relevance 0.27

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