INT7234

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Context Info
Confidence 0.47
First Reported 1982
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 43
Total Number 47
Disease Relevance 21.59
Pain Relevance 12.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 6
plasma 2
neurons 2
peptidergic neuron 1
neural 1
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 190 100.00 Very High Very High Very High
antagonist 92 100.00 Very High Very High Very High
narcan 55 100.00 Very High Very High Very High
Somatostatin 9 100.00 Very High Very High Very High
Endogenous opioid 9 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
imagery 2 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
5HT 10 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 38 100.00 Very High Very High Very High
Depression 18 99.98 Very High Very High Very High
Affective Disorder 2 99.98 Very High Very High Very High
Uterine Fibroids 18 99.92 Very High Very High Very High
Ovarian Cancer 3 99.72 Very High Very High Very High
Endometriosis (extended) 25 99.68 Very High Very High Very High
Necrosis 7 99.68 Very High Very High Very High
Anxiety Disorder 3 99.60 Very High Very High Very High
Disease 79 99.16 Very High Very High Very High
Apoptosis 12 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although necrosis of leiomyomas is associated with GnRH agonist treatment, the lack of significant pleomorphism or mitotic activity distinguishes these altered leiomyomas from leiomyosarcomas.
GnRH Binding (associated) of associated with leiomyosarcoma, necrosis, uterine fibroids and agonist
1) Confidence 0.47 Published 1993 Journal Hum. Pathol. Section Abstract Doc Link 8406417 Disease Relevance 1.48 Pain Relevance 0.36
Tibolone used in association with GnRH-a may provide long-term medical treatment for women with PMS.


GnRH Binding (association) of
2) Confidence 0.47 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11172843 Disease Relevance 0 Pain Relevance 0
GnRH is secreted from the hypothalamus in a pulsatile manner and binds to high-affinity cell surface receptors in the pituitary gland, activating a chain of events that lead to synthesis and secretion of LH and follicle-stimulating hormone (FSH).5 LH stimulates testosterone production and secretion by the Leydig cells of the testes.
GnRH Binding (binds) of in pituitary gland
3) Confidence 0.44 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 0.82 Pain Relevance 0
These interactions between TNF, GnRH and gonadotrophs are discussed.
GnRH Binding (interactions) of in gonadotrophs
4) Confidence 0.37 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17985235 Disease Relevance 1.08 Pain Relevance 0.38
Although the information from teleosts also suggests that endogenous opioids modulate GnRH secretion and influence gonadotropic hormone release, the anatomical substrate in which opiate peptides and GnRH may interact has not been studied.
GnRH Binding (interact) of associated with endogenous opioid and opiate
5) Confidence 0.37 Published 2000 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 10753565 Disease Relevance 0 Pain Relevance 0.20
Our review describes most of the currently published studies employing these and other substances in association with the commonly used GnRH agonists in patients with symptomatic endometriosis.
GnRH Binding (association) of associated with endometriosis and agonist
6) Confidence 0.37 Published 1997 Journal Semin. Reprod. Endocrinol. Section Abstract Doc Link 9383836 Disease Relevance 0.65 Pain Relevance 0.37
Depressive symptoms associated with gonadotropin-releasing hormone agonists.
gonadotropin-releasing hormone Binding (associated) of associated with depression and agonist
7) Confidence 0.37 Published 1998 Journal Depress Anxiety Section Title Doc Link 9706454 Disease Relevance 0.99 Pain Relevance 0.54
After binding of its ligand the tumor GnRH receptor couples to G-protein alphai and activates a variety of intracellular signaling mechanisms. (1) Through activation of a protein tyrosine phosphatase, autophosphorylation of growth factor receptors is reverted leading to an inhibition of mitogenic signaling and reduced cell proliferation. (2) Through activation of nuclear factor kappa B antiapoptotic mechanisms are induced protecting tumor cells from apoptosis induced, for example, by doxorubicin. (3) Through activation of the Jun kinase pathway AP-1 is induced, leading to cell cycle arrest in the G0/G1 phase.
GnRH Binding (binding) of associated with cancer and apoptosis
8) Confidence 0.37 Published 2003 Journal Endocr. Relat. Cancer Section Abstract Doc Link 12790790 Disease Relevance 0.54 Pain Relevance 0.04
Stress hormones such as catecholamines (adrenalin, nonadrenaline and dopamine) and the hypothalamic-pituitary-adrenal axis interact with hormones which are responsible for normal ovulatory cycles: i.e., gonadotropin releasing hormone (GnRH), prolactin, LH and FSH.
GnRH Binding (interact) of in pituitary associated with stress, dopamine and catecholamine
9) Confidence 0.37 Published 1992 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 1618356 Disease Relevance 1.38 Pain Relevance 0.20
Stress hormones such as catecholamines (adrenalin, nonadrenaline and dopamine) and the hypothalamic-pituitary-adrenal axis interact with hormones which are responsible for normal ovulatory cycles: i.e., gonadotropin releasing hormone (GnRH), prolactin, LH and FSH.
gonadotropin releasing hormone Binding (interact) of in pituitary associated with stress, dopamine and catecholamine
10) Confidence 0.37 Published 1992 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 1618356 Disease Relevance 1.38 Pain Relevance 0.20
There is a suggestion that leiomyomas subjected to preoperative GnRH agonist treatment showed increased cellularity (P = .04); necrosis (P < .001) was associated with preoperative GnRH agonist treatment.
GnRH Binding (associated) of associated with necrosis, uterine fibroids and agonist
11) Confidence 0.36 Published 1993 Journal Hum. Pathol. Section Abstract Doc Link 8406417 Disease Relevance 1.34 Pain Relevance 0.41
The A-type potassium-channel antagonist 4-aminopyridine (1 mM) increased both firing rate and GnRH secretion, demonstrating the presence of A-type currents in these cells and supporting the hypothesis that electrical activity is associated with GnRH release.
GnRH Binding (associated) of associated with antagonist
12) Confidence 0.36 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11431490 Disease Relevance 0 Pain Relevance 0.17
There was no consistent effect of any treatment on hypothalamic concentration of pro-LH releasing hormone (RH) (LHRH), LHRH, or on steady-state levels of LHRH mRNA.
LHRH Neg (no) Binding (concentration) of
13) Confidence 0.36 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756033 Disease Relevance 0.12 Pain Relevance 0.20
There was no consistent effect of any treatment on hypothalamic concentration of pro-LH releasing hormone (RH) (LHRH), LHRH, or on steady-state levels of LHRH mRNA.
LHRH Neg (no) Binding (concentration) of
14) Confidence 0.36 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756033 Disease Relevance 0.12 Pain Relevance 0.20
CONCLUSION(S): Tibolone administered in association with GnRH-a does not reduce the therapeutic effect of GnRH-a in women affected by PMS.
GnRH Binding (association) of
15) Confidence 0.36 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11172843 Disease Relevance 0.05 Pain Relevance 0
Group I received combination/sequential therapy with depot GnRH agonist (GnRH-a) for 3 months, followed by weekly RU 486 for 9 months.
GnRH Binding (therapy) of associated with agonist
16) Confidence 0.36 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626860 Disease Relevance 0.51 Pain Relevance 0.34
Gynecomastia and breast pain/tenderness occur commonly in men undergoing antiandrogen therapy and are also associated to a lesser extent with orchiectomy and GnRH agonist treatment.46 Prophylactic breast irradiation52 or tamoxifen treatment53 can be effective in reducing the incidence and severity of breast pain and gynecomastia, but are both associated with an additional side-effect burden.
GnRH Binding (associated) of associated with pain, agonist and gynecomastia
17) Confidence 0.34 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 1.28 Pain Relevance 0.53
While it remains the “gold standard” ADT, orchiectomy is irreversible and associated with psychological drawbacks, and has therefore now largely been replaced by medical castration, as patients generally prefer this option.44 GnRH agonists are currently the most commonly used form of medical ADT, as treatment with these agents is associated with improved quality of life compared with orchiectomy.44 Nonetheless, the clinical flare associated with GnRH agonists can worsen disease symptoms12 and deleteriously impact upon the quality of life of some patients with advanced disease.
GnRH Binding (associated) of associated with agonist and disease
18) Confidence 0.34 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 0.88 Pain Relevance 0.10
The advantages of GnRH antagonists are that they do not cause the initial surge in testosterone associated with LHRH agonists and they rapidly achieve castrate androgen levels.
LHRH Binding (associated) of associated with antagonist and agonist
19) Confidence 0.33 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504071 Disease Relevance 0.15 Pain Relevance 0.21
This method does not perturb endocrine function and allows continuous monitoring of GnRH and gonadotropin (Gn) secretion, determination of the amount of GnRH perfusing gonadotropes, and direct measurements of the amounts of Gn secreted.
GnRH Spec (determination) Binding (monitoring) of
20) Confidence 0.31 Published 1993 Journal Endocrinology Section Abstract Doc Link 8419124 Disease Relevance 0 Pain Relevance 0.16

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