INT72349

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.76
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
nucleus accumbens 1
dentate gyrus 1
brains 1
superior cervical ganglion 1
iris 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 4 99.92 Very High Very High Very High
Neuropeptide 12 99.86 Very High Very High Very High
fluoxetine 20 98.92 Very High Very High Very High
depression 16 98.60 Very High Very High Very High
Nucleus accumbens 8 98.20 Very High Very High Very High
Anterior cingulate 4 97.56 Very High Very High Very High
agonist 6 94.48 High High
antidepressant 8 87.28 High High
Serotonin 4 79.76 Quite High
antagonist 2 50.96 Quite High
Disease Link Frequency Relevance Heat
Depression 16 98.60 Very High Very High Very High
Ganglion Cysts 2 98.28 Very High Very High Very High
Sprains And Strains 16 95.12 Very High Very High Very High
Depressive Disorder 4 84.72 Quite High
Increased Venous Pressure Under Development 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization histochemistry was used to measure mRNA expression levels of NPY and NPY receptors, Y1 and Y2, in the FSL as compared to the control Flinder resistant Line rats (FRL).
Transcription (expression) of Y1
1) Confidence 0.41 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.32 Pain Relevance 0.52
Y1 receptor mRNA expression was decreased in different cortical regions (retrosplenial, anterior cingulate, and occipital) and in the hippocampal dentate gyrus.
Transcription (expression) of Y1 in dentate gyrus associated with anterior cingulate
2) Confidence 0.41 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.38 Pain Relevance 0.67
Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment.
Transcription (expression) of Y1 in brains associated with depression, neuropeptide and fluoxetine
3) Confidence 0.41 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9729278 Disease Relevance 0.39 Pain Relevance 0.59
In contrast, Y1 mRNA levels tended to be decreased by fluoxetine in the nucleus accumbens of the FSL rats, but increased in the FRL.
Transcription (levels) of Y1 in nucleus accumbens associated with nucleus accumbens and fluoxetine
4) Confidence 0.41 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.48 Pain Relevance 0.83
Reverse transcription-polymerase chain reaction analysis has demonstrated mRNA expression for both Y1 and Y2 receptors in the superior cervical ganglion and iris.
Transcription (expression) of Y1 in iris associated with ganglion cysts
5) Confidence 0.12 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374743 Disease Relevance 0.10 Pain Relevance 0.16
Reverse transcription-polymerase chain reaction analysis has demonstrated mRNA expression for both Y1 and Y2 receptors in the superior cervical ganglion and iris.
Transcription (expression) of Y1 in superior cervical ganglion associated with ganglion cysts
6) Confidence 0.04 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374743 Disease Relevance 0.10 Pain Relevance 0.16

General Comments

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