INT72350

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Context Info
Confidence 0.63
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 6.28
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
blood 2
ARC 2
arcuate nucleus 2
tail 1
sciatic nerves 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 14 100.00 Very High Very High Very High
Neuropeptide 39 99.86 Very High Very High Very High
Intracerebroventricular 5 99.64 Very High Very High Very High
antagonist 14 98.82 Very High Very High Very High
Inflammation 20 98.60 Very High Very High Very High
antinociception 6 98.24 Very High Very High Very High
Endogenous opioid 5 97.80 Very High Very High Very High
depression 6 97.00 Very High Very High Very High
Sciatic nerve 4 95.36 Very High Very High Very High
Codeine 218 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 18 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 99.90 Very High Very High Very High
Aids-related Complex 18 99.28 Very High Very High Very High
INFLAMMATION 16 98.60 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.36 Very High Very High Very High
Depression 8 97.80 Very High Very High Very High
Lordosis 15 93.64 High High
Bradycardia 3 84.20 Quite High
Aging 2 75.00 Quite High
Nociception 4 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Y1R antagonist (Cys31, Nva34)-Neuropeptide Y (27-36)2 prevented estrogen-induced Y1R and MOR activation/internalization.
Positive_regulation (induced) of Y1R associated with antagonist and neuropeptide
1) Confidence 0.63 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.15 Pain Relevance 0.49
To determine whether NPY and endogenous opioids interact, we tested the hypothesis that estrogen-induced MOR activation is mediated through NPY-Y1 receptor (Y1R) activation.
Positive_regulation (activation) of Y1R associated with endogenous opioid
2) Confidence 0.45 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.09 Pain Relevance 0.43
NPY reversed the progesterone blockade of estradiol-induced Y1R and MOR internalization in the arcuate nucleus and MPN, respectively.
Positive_regulation (induced) of Y1R in arcuate nucleus
3) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.16 Pain Relevance 0.45
Estradiol administration or intracerebroventricular injection of NPY activated/internalized Y1R in the arcuate nucleus and MOR in the MPN of ovariectomized (OVX) rats.
Positive_regulation (activated/internalized) of Y1R in arcuate nucleus associated with intracerebroventricular
4) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.14 Pain Relevance 0.48
In situ hybridization histochemistry was used to measure mRNA expression levels of NPY and NPY receptors, Y1 and Y2, in the FSL as compared to the control Flinder resistant Line rats (FRL).
Positive_regulation (levels) of Y1
5) Confidence 0.38 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.32 Pain Relevance 0.52
Additionally, there were marked increases of Y1 receptor in the bilateral ARC of rats with inflammation tested by immunohistochemistry, while no significant changes of NPY were observed, implicating that the increased Y1 receptor has an important effect in the NPY-induced antinociception.
Positive_regulation (increased) of Y1 receptor in ARC associated with antinociception, inflammation and aids-related complex
6) Confidence 0.37 Published 2005 Journal Pain Section Abstract Doc Link 16216414 Disease Relevance 1.24 Pain Relevance 0.95
Additionally, there were marked increases of Y1 receptor in the bilateral ARC of rats with inflammation tested by immunohistochemistry, while no significant changes of NPY were observed, implicating that the increased Y1 receptor has an important effect in the NPY-induced antinociception.
Positive_regulation (increases) of Y1 receptor in ARC associated with antinociception, inflammation and aids-related complex
7) Confidence 0.37 Published 2005 Journal Pain Section Abstract Doc Link 16216414 Disease Relevance 1.29 Pain Relevance 0.94
Specificity assays were performed by equally dividing the flow-through radiolabeled FC5 and FC45 into three Sepharose columns (300 ?
Positive_regulation (radiolabeled) of FC5
8) Confidence 0.17 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.43
NPY reversed the progesterone blockade of estradiol-induced Y1R and MOR internalization in the arcuate nucleus and MPN, respectively.
Positive_regulation (induced) of Y1R in MPN
9) Confidence 0.14 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.16 Pain Relevance 0.45
The FC5 mini-aptamer (FC5L) was stabilized by extending the existing 3 bp stem with two GC base pairs (Figure 7B), based on the assumption that a few nucleotides present on each end of the original mini-aptamer are unessential for codeine-binding.
Positive_regulation (stabilized) of FC5 in stem associated with codeine
10) Confidence 0.14 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.09
Neuropeptide Y and Y1-receptor agonists increase blood flow through arteriovenous anastomoses in rat tail.
Positive_regulation (increase) of Y1-receptor in tail associated with agonist and neuropeptide
11) Confidence 0.13 Published 1998 Journal J. Appl. Physiol. Section Title Doc Link 9655790 Disease Relevance 0.09 Pain Relevance 0.27
It is suggested that activation of Y1 receptors may be primarily responsible for the reflex depressive effect of i.t. neuropeptide Y in rats with intact sciatic nerves, whereas both Y1 and Y2 receptors may be involved in mediating the depressive effect of NPY after axotomy.
Positive_regulation (activation) of Y1 in sciatic nerves associated with depression, neuropeptide and sciatic nerve
12) Confidence 0.12 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375701 Disease Relevance 0.35 Pain Relevance 0.55
Northern blot techniques were used to evaluate induction by stress of adrenal NPY mRNA and adrenal ppENK mRNA.
Positive_regulation (induction) of NPY mRNA associated with stress
13) Confidence 0.10 Published 1998 Journal Mech. Ageing Dev. Section Abstract Doc Link 9622227 Disease Relevance 0.78 Pain Relevance 0.08
We observed that the induction by stress of adrenal NPY mRNA is impaired with age but the stress-induced elevation of adrenal ppENK mRNA, blood glucose, and corticosterone show no evidence of age-related impairments.
Positive_regulation (induction) of NPY mRNA in blood associated with stress
14) Confidence 0.10 Published 1998 Journal Mech. Ageing Dev. Section Abstract Doc Link 9622227 Disease Relevance 0.87 Pain Relevance 0.08
Results suggest that NPY, released from sympathetic nerves during long-duration, high-frequency stimulation, activates Y1 receptors on iris arterioles to produce vasoconstriction and to potentiate responses to low concentrations of norepinephrine.
Positive_regulation (activates) of Y1 in iris associated with increased venous pressure under development
15) Confidence 0.09 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374743 Disease Relevance 0.15 Pain Relevance 0.19
In the guinea pig, the Y2-receptor-preferring fragment NPY(3-36) and the selective Y1-receptor antagonist H 409/22 were used to confirm that the increase in blood pressure was mediated solely through the Y1-receptor and the vagal inhibition solely through the Y2-receptor.
Positive_regulation (mediated) of Y1-receptor in blood associated with pressure and volume under development and antagonist
16) Confidence 0.05 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11026645 Disease Relevance 0.47 Pain Relevance 0.16

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