INT72370

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 2
Speculated 6
Reported most in Body
Documents 82
Total Number 88
Disease Relevance 57.52
Pain Relevance 24.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
fibroblasts 5
neutrophil 5
platelet 4
lungs 4
plasma 3
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1397 100.00 Very High Very High Very High
chemokine 151 100.00 Very High Very High Very High
rheumatoid arthritis 876 99.90 Very High Very High Very High
fibrosis 483 99.88 Very High Very High Very High
Snapping jaw 24 99.84 Very High Very High Very High
dexamethasone 182 99.60 Very High Very High Very High
cINOD 86 99.58 Very High Very High Very High
Central nervous system 47 99.48 Very High Very High Very High
cytokine 603 99.44 Very High Very High Very High
agonist 30 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Synovitis 26 99.92 Very High Very High Very High
Rheumatoid Arthritis 1004 99.90 Very High Very High Very High
Pulmonary Fibrosis 161 99.88 Very High Very High Very High
Targeted Disruption 103 99.88 Very High Very High Very High
Stomach Cancer 349 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 24 99.84 Very High Very High Very High
Thrombosis 5 99.82 Very High Very High Very High
Injury 256 99.76 Very High Very High Very High
INFLAMMATION 1232 99.48 Very High Very High Very High
Hypoxia 38 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and MMPs/TIMPs.7 The results of this study show that ACEI preparation Benazepril can remarkably reduce TLR4, TNF-?
Gene_expression (/) of TIMP associated with metalloproteinase
1) Confidence 0.65 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.65 Pain Relevance 0.23
In humans, increased levels of TIMP protein and RNA are observed in lungs of patients with idiopathic pulmonary fibrosis, and TIMP expression there exceeds that of MMP [12].
Gene_expression (expression) of TIMP in lungs associated with fibrosis and pulmonary fibrosis
2) Confidence 0.64 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.68 Pain Relevance 0.28
Increased TIMP-1 expression has been observed in lung extracts and in BAL fluids after bleomycin administration and after the transfer of the active TGF-beta gene to "fibrosis-prone" C57BL/6 mice [11,14].
Gene_expression (expression) of TIMP in lung associated with fibrosis
3) Confidence 0.64 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.64 Pain Relevance 0.31
Circulating protein levels of ALCAM, ICAM1, and TIMP1 in the same mouse plasma used in the proteomic approach were measured by ELISA (Figure 5).
Gene_expression (levels) of TIMP1 in plasma
4) Confidence 0.62 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 0.73 Pain Relevance 0
At day 1 this was due to the lower MMP-9 level and higher TIMP-1 level in the BAL from WT mice, and at day 14, only to the latter.
Gene_expression (level) of TIMP
5) Confidence 0.55 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.80 Pain Relevance 0.24
Determination of IL-6, TIMP-1 and pro-MMP9 levels in BAL
Gene_expression (levels) of TIMP
6) Confidence 0.55 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0 Pain Relevance 0.03
CONCLUSIONS: This study indicates that borneol has anti-fibrosis activity and the mechanism may partly be relevant to its inhibiting effects on fibroblasts mitosis, collagen and TIMP-1 production.
Gene_expression (production) of TIMP-1 in fibroblasts
7) Confidence 0.55 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.05 Pain Relevance 0
Moreover borneol could significantly (P < 0.05) decrease MMP-2 activity, and very significantly (P < 0.01) inhibit TIMP-1 production.
Gene_expression (production) of TIMP-1
8) Confidence 0.55 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.06 Pain Relevance 0
METHODS: Two preliminary trials were conducted to determine the minimum effective levels of GLA and EPA intake needed to reduce leukotriene biosynthesis and prevent increases in plasma arachidonic acid (AA) concentrations.
Spec (determine) Gene_expression (levels) of EPA in plasma
9) Confidence 0.55 Published 2003 Journal Clin Ther Section Body Doc Link 12852710 Disease Relevance 0.08 Pain Relevance 0
Cytokines stimulate inflammatory and smooth muscle cells in the intima to produce degradative enzymes, including metalloproteinases that can weaken the fibrous cap of atherosclerotic lesions and make them vulnerable to rupture.
Gene_expression (produce) of metalloproteinases in smooth muscle cells associated with inflammation, rupture, atherosclerosis, metalloproteinase and cytokine
10) Confidence 0.55 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9375937 Disease Relevance 1.54 Pain Relevance 0.45
Bleomycin-induced pulmonary fibrosis, for example, causes the expression of significant levels of TIMP-1 [13,14].
Gene_expression (expression) of TIMP associated with fibrosis and pulmonary fibrosis
11) Confidence 0.50 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.64 Pain Relevance 0.37
METHODS: Primary mice oral fibroblasts were cultured, the effects of borneol on fibroblasts proliferation, cytotoxicity, collagen production, matrix metalloproteinases-2,9 (MMP-2,9) activities and tissue inhibitors of metalloproteinase 1 (TIMP-1) production were tested by methyl thiazolyl tetrazolium assay, lactic dehydrogenase activity assay, chloramine T method, gelatin zymography and enzyme-linked immunosorbent assay, respectively.
Gene_expression (production) of TIMP-1 in fibroblasts
12) Confidence 0.48 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.09 Pain Relevance 0
In contrast, we find that silica induced expression of the MMP inhibitor, TIMP1, in the lung of mice, and this enhanced expression was not altered in the lungs of the CCSP-dnI?
Gene_expression (expression) of TIMP1 in lungs
13) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.32 Pain Relevance 0.16
Previously, it was reported that EPA decreased neutrophil infiltration in an animal model of contact dermatitis [28] and neutrophil transmigration through cultured endothelial cells [29].
Gene_expression (decreased) of EPA in neutrophil associated with contact dermatitis
14) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.94 Pain Relevance 0.20
However, EPA administration reduced the phosphorylation of NF-?
Gene_expression (administration) of EPA
15) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.73 Pain Relevance 0.13
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Gene_expression (expressed) of TIMP-1 associated with fibrosis
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.87 Pain Relevance 0.31
In addition, transgenic mice overexpressing human TIMP-1 developed more liver fibrosis when subjected to chronic CCl4 administration [39], and demonstrated attenuated spontaneous fibrosis resolution [40].
Gene_expression (overexpressing) of TIMP-1 in liver associated with targeted disruption, fibrosis and cirrhosis
17) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.20 Pain Relevance 0.48
In the present study, we measured the expression of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9, in the sera and culture supernatants of dermal fibroblasts from SSc patients and compared them with serum concentrations of transforming growth factor ?
Gene_expression (expression) of TIMP in fibroblasts associated with metalloproteinase and systemic sclerosis
18) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.41 Pain Relevance 0.41
In response to TNF, but in the absence of EPA, a small population of adherent neutrophils (?
Neg (absence) Gene_expression (absence) of EPA in neutrophils
19) Confidence 0.38 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.68 Pain Relevance 0.18
Neutrophils were also treated with the DP1 receptor agonist BW245c (Cayman Chemicals) prior to perfusion over EPA- and TNF-?
Gene_expression (perfusion) of EPA in Neutrophils associated with agonist
20) Confidence 0.38 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.12 Pain Relevance 0.22

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