INT72372

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 13.60
Pain Relevance 7.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
spinal cord 2
brain 2
DRG 2
cortex 2
hearts 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
Potency 2 100.00 Very High Very High Very High
nociceptor 9 99.96 Very High Very High Very High
dorsal root ganglion 10 99.80 Very High Very High Very High
Eae 9 99.80 Very High Very High Very High
Spinal cord 50 98.84 Very High Very High Very High
Hyperalgesia 35 98.34 Very High Very High Very High
amygdala 12 98.28 Very High Very High Very High
narcan 1 98.12 Very High Very High Very High
Inflammation 116 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 14 99.98 Very High Very High Very High
Chronic Hepatitis 62 99.84 Very High Very High Very High
Hypoxia 6 99.84 Very High Very High Very High
Ganglion Cysts 15 99.80 Very High Very High Very High
Inflammatory Pain 5 99.80 Very High Very High Very High
Cirrhosis 114 99.76 Very High Very High Very High
Middle Cerebral Artery Infarction 37 99.28 Very High Very High Very High
Hepatitis 66 98.52 Very High Very High Very High
Hyperalgesia 40 98.34 Very High Very High Very High
INFLAMMATION 128 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next to STAT3 phosphorylation, HCV induces ERK1/2 phosphorylation [27].
Positive_regulation (induces) of Phosphorylation (phosphorylation) of ERK1 associated with hepatitis c virus infection
1) Confidence 0.67 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.67 Pain Relevance 0.06
Western blot analysis showed that both peptide forms stimulated ERK1/2 and JNK phosphorylation, while they both inhibited p38 MAPK phosphorylation.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of ERK1
2) Confidence 0.67 Published 2008 Journal J. Mol. Neurosci. Section Abstract Doc Link 18607779 Disease Relevance 0 Pain Relevance 0.49
Epinephrine, which induces hyperalgesia by direct action at beta(2)-adrenergic receptors on primary afferent nociceptors, stimulated phosphorylation of ERK1/2 in cultured rat dorsal root ganglion cells.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of ERK1 in nociceptors associated with ganglion cysts, dorsal root ganglion, hyperalgesia and nociceptor
3) Confidence 0.67 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.62 Pain Relevance 0.84
Ropivacaine also induced an increase in phosphorylation of PKC and p44/42 MAPK, and membrane translocation of Rho kinase in accordance with the contractile responses, which were also significantly inhibited by bisindolylmaleimide I and calphostin C, Y 27632, and PD 098059, correspondingly.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of p44
4) Confidence 0.67 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
Hippocampal slices superfused with 4AP-containing medium exhibited a marked activation of ERK1/2 phosphorylation that peaked within about 20 min.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of ERK1
5) Confidence 0.55 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086522 Disease Relevance 0.17 Pain Relevance 0.12
Our studies show that the LOX metabolites, 5-HETE, 12-HETE and LTB4 stimulate MEK/ERK phosphorylation [76-78,80].
Positive_regulation (stimulate) of Phosphorylation (phosphorylation) of ERK
6) Confidence 0.49 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.21 Pain Relevance 0
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Positive_regulation (accumulation) of Phosphorylation (phosphorylation) of ERK1
7) Confidence 0.49 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
Activation of MAPK cascade might be mediated by neurotensin receptor via Egr1, which is known to be upregulated in response to persistent inflammatory pain [29] and stimulates Erk1/2 phosphorylation [36].
Positive_regulation (stimulates) of Phosphorylation (phosphorylation) of Erk1 associated with eae
8) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 0.99 Pain Relevance 0.98
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Positive_regulation (butyrate-induced) of Phosphorylation (phosphorylation) of ERK1
9) Confidence 0.49 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Positive_regulation (ropivacaine-induced) of Phosphorylation (phosphorylation) of p44
10) Confidence 0.49 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
In addition, pressure rapidly increased the phosphorylation of p44/42 and p38 MAPK.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p44
11) Confidence 0.49 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.12 Pain Relevance 0.18
G. elata resulted in phosphorylation and dephosphorylation of ERK1/2 and JNK1/2-p38 MAPKs (members of the serine/threonine kinase family), respectively, as revealed by Western blot analysis.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of ERK1
12) Confidence 0.49 Published 2004 Journal Life Sci. Section Abstract Doc Link 15261768 Disease Relevance 0.77 Pain Relevance 0.09
Whereas, renal arterial and carotid blood flow significantly drop and phosphorylated p38 MAPK and ERK1/2 levels significantly increase in aorta and the cortex of the kidney respectively by two weeks of STZ-induced diabetes [35], little is known about the effects of acute hyperglycemia on neurons.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of ERK1 in kidney associated with hyperglycemia and diabetes mellitus
13) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.72 Pain Relevance 0.15
Ropivacaine also induced an increase in phosphorylation of PKC and p44/42 MAPK, and membrane translocation of Rho kinase in accordance with the contractile responses, which were also significantly inhibited by bisindolylmaleimide I and calphostin C, Y 27632, and PD 098059, correspondingly.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p44
14) Confidence 0.45 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
The phosphorylated form threonine/tyrosine (Thr/Tyr)-phosphorylated ERK1/2 was strongly increased in CH and LDH.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of ERK1 associated with chronic hepatitis
15) Confidence 0.45 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.17 Pain Relevance 0.04
Third, similar to our results, 2 hours of MCAO followed by reperfusion in the rat causes phosphorylation of ERK1/2 in both the ipsilateral and contralateral cortex after 6 hours of reperfusion [50].
Positive_regulation (causes) of Phosphorylation (phosphorylation) of ERK1 in cortex associated with middle cerebral artery infarction
16) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.73 Pain Relevance 0.03
However, s.c. administration of bee venom into the plantar surface of one hindpaw, which could produce a prolonged tonic, monophasic nociceptive response characterized by continuously flinching or lifting the injected paw for 1–2 h [37,38], significantly elevated the phosphorylation level of both ERK1 and ERK2 in the ipsilateral spinal cord (Fig. 1A, Tables 1 and 2).
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of ERK1 in spinal cord associated with nociception and spinal cord
17) Confidence 0.41 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.41 Pain Relevance 0.59
Western blotting revealed that DADLE's protection was correlated to increase in phosphorylation of the kinases Akt and ERK1 and -2 in reperfused hearts (2.5 +/- 0.5, 1.6 +/- 0.2, and 2.3 +/- 0.7-fold of baseline levels, P < 0.05 vs. control).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK1 in hearts
18) Confidence 0.39 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.30 Pain Relevance 0.43
We found that N/OFQ, PDBu, and IDB increased the amount of phosphorylated ERK-1/2 and Elk-1; U0126, a specific inhibitor for ERK-1/2, attenuated the inhibitory effect of N/OFQ on the I(K).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of ERK-1
19) Confidence 0.35 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20331962 Disease Relevance 0 Pain Relevance 0.24
Western blotting analysis of DRG extracts detected phosphorylation of ERK1 and ERK2 (extracellular signal-regulated kinases) that peaked 10 min after exposure to 17beta-estradiol.
Positive_regulation (detected) of Phosphorylation (phosphorylation) of ERK1 in DRG associated with dorsal root ganglion
20) Confidence 0.34 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541884 Disease Relevance 0.82 Pain Relevance 0.31

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