INT72373

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.18
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 10 100.00 Very High Very High Very High
dexamethasone 1 99.84 Very High Very High Very High
Glutamate 3 91.52 High High
antagonist 1 91.32 High High
tetrodotoxin 1 88.80 High High
gABA 1 88.16 High High
Glutamate receptor 3 77.68 Quite High
opioid receptor 4 77.40 Quite High
agonist 2 75.00 Quite High
MU agonist 2 68.72 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, they enhanced the AMPA-induced CREB phosphorylation and PEnk gene expression.
Phosphorylation (phosphorylation) of PEnk gene
1) Confidence 0.62 Published 2006 Journal Cereb. Cortex Section Abstract Doc Link 16407481 Disease Relevance 0 Pain Relevance 0.44
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Phosphorylation (phosphorylation) of enkephalin associated with enkephalin
2) Confidence 0.61 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.53
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Phosphorylation (phosphorylation) of enkephalin associated with enkephalin
3) Confidence 0.61 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.53
The combined treatment with FSK and PMA additively increased the proENK mRNA level, which was correlated with AP-1 or ENKCRE-2 DNA binding activity, and CREB phosphorylation.
Phosphorylation (phosphorylation) of proENK mRNA
4) Confidence 0.50 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.05

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