INT72375

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Context Info
Confidence 0.80
First Reported 1997
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 87
Total Number 89
Disease Relevance 43.66
Pain Relevance 30.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
hippocampus 5
hearts 3
PDL 3
brain 2
spinal cord 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 985 100.00 Very High Very High Very High
nociceptor 66 100.00 Very High Very High Very High
Enkephalin 22 100.00 Very High Very High Very High
analgesia 4 99.92 Very High Very High Very High
Endep 4 99.78 Very High Very High Very High
transcutaneous nerve stimulation 7 99.72 Very High Very High Very High
dorsal root ganglion 39 99.62 Very High Very High Very High
Potency 5 99.60 Very High Very High Very High
Eae 13 99.58 Very High Very High Very High
Stimulus evoked pain 17 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 228 100.00 Very High Very High Very High
Hepatitis C Virus Infection 36 99.82 Very High Very High Very High
Myocardial Infarction 4 99.78 Very High Very High Very High
Cirrhosis 285 99.76 Very High Very High Very High
Pain 1311 99.74 Very High Very High Very High
Ganglion Cysts 46 99.62 Very High Very High Very High
Inflammatory Pain 17 99.58 Very High Very High Very High
Hypersensitivity 45 99.54 Very High Very High Very High
Temporomandibular Joint Syndrome 4 99.54 Very High Very High Very High
Hypoxia 32 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extracellular signal-regulated kinases 1 and 2 phosphorylated neurons in the tele- and diencephalon of rat after visceral pain stimulation: an immunocytochemical study.
Phosphorylation (phosphorylated) of Extracellular signal-regulated kinases 1 in diencephalon associated with visceral pain and nociceptor
1) Confidence 0.80 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11479017 Disease Relevance 0.06 Pain Relevance 0.52
Next to STAT3 phosphorylation, HCV induces ERK1/2 phosphorylation [27].
Phosphorylation (phosphorylation) of ERK1 associated with hepatitis c virus infection
2) Confidence 0.80 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.66 Pain Relevance 0.06
Third, similar to our results, 2 hours of MCAO followed by reperfusion in the rat causes phosphorylation of ERK1/2 in both the ipsilateral and contralateral cortex after 6 hours of reperfusion [50].
Phosphorylation (phosphorylation) of ERK1 in cortex associated with middle cerebral artery infarction
3) Confidence 0.80 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.73 Pain Relevance 0.03
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Phosphorylation (phosphorylation) of ERK1
4) Confidence 0.80 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Phosphorylation (phosphorylation) of ERK1
5) Confidence 0.80 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
Endostatin also interacts with VEGF signal transduction by reducing VEGF-induced kinase (Erk1/2) phosphorylation [25].
Phosphorylation (phosphorylation) of Erk1
6) Confidence 0.80 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.17 Pain Relevance 0.16
Activation of MAPK cascade might be mediated by neurotensin receptor via Egr1, which is known to be upregulated in response to persistent inflammatory pain [29] and stimulates Erk1/2 phosphorylation [36].
Phosphorylation (phosphorylation) of Erk1 associated with eae
7) Confidence 0.80 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 0.94 Pain Relevance 0.95
In the canine samples, an up regulation of the levels of phosphorylated ERK1/2 was observed in CH and LDH.
Phosphorylation (phosphorylated) of ERK1 associated with chronic hepatitis
8) Confidence 0.80 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.66 Pain Relevance 0.06
We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase cascade, in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons by noxious gastric distention (GD) and its involvement in acute visceral pain in rats.
Spec (investigated) Phosphorylation (phosphorylation) of ERK1 in ganglion associated with ganglion cysts, dorsal root ganglion and visceral pain
9) Confidence 0.80 Published 2008 Journal Gastroenterology Section Abstract Doc Link 18395090 Disease Relevance 0.29 Pain Relevance 0.36
Western blot analysis showed that both peptide forms stimulated ERK1/2 and JNK phosphorylation, while they both inhibited p38 MAPK phosphorylation.
Phosphorylation (phosphorylation) of ERK1
10) Confidence 0.80 Published 2008 Journal J. Mol. Neurosci. Section Abstract Doc Link 18607779 Disease Relevance 0 Pain Relevance 0.49
Additionally, we demonstrated increased extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation without altering Jun N-terminal kinase (JNK) and p38(MAPK) phosphorylation.
Neg (without) Phosphorylation (phosphorylation) of ERK1
11) Confidence 0.80 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.28 Pain Relevance 0.26
Compared with adult (6-month) and aged (27-month) rats, very aged rats (33-month) had higher levels of blood glucose, phosphorylation of soleus p38-MAPK and extracellular-regulated kinase 1/2 (ERK1/2), superoxide and oxidatively modified proteins (p<0.05), and these changes were associated with decreased soleus Glut4 protein abundance (p<0.05).
Phosphorylation (phosphorylation) of ERK1 in blood
12) Confidence 0.80 Published 2009 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 19177471 Disease Relevance 0 Pain Relevance 0
Because the periodontal ligament (PDL) contains numerous nociceptors and mechanoceptors, phosphorylation of ERK1/2 was investigated in nerve fibers of the PDL to elucidate the role of constitutive local activation of ERK1/2 in peripheral sensitization.
Spec (investigated) Phosphorylation (phosphorylation) of ERK1 in periodontal ligament associated with nociceptor and peripheral sensitization
13) Confidence 0.80 Published 2009 Journal J. Periodontol. Section Abstract Doc Link 19405839 Disease Relevance 0.09 Pain Relevance 0.29
Myocardial infarct size, the phosphorylation of ERK1/2, Bcl2, Bax and cytochrome c and the expression of genes influencing Ca2+ homeostasis were assessed.
Phosphorylation (phosphorylation) of ERK1 associated with myocardial infarction
14) Confidence 0.80 Published 2010 Journal Physiol Res Section Abstract Doc Link 19681651 Disease Relevance 0.63 Pain Relevance 0.93
Our studies show that the LOX metabolites, 5-HETE, 12-HETE and LTB4 stimulate MEK/ERK phosphorylation [76-78,80].
Phosphorylation (phosphorylation) of ERK
15) Confidence 0.80 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.20 Pain Relevance 0
Ropivacaine also induced an increase in phosphorylation of PKC and p44/42 MAPK, and membrane translocation of Rho kinase in accordance with the contractile responses, which were also significantly inhibited by bisindolylmaleimide I and calphostin C, Y 27632, and PD 098059, correspondingly.
Phosphorylation (phosphorylation) of p44
16) Confidence 0.80 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
Epinephrine, which induces hyperalgesia by direct action at beta(2)-adrenergic receptors on primary afferent nociceptors, stimulated phosphorylation of ERK1/2 in cultured rat dorsal root ganglion cells.
Phosphorylation (phosphorylation) of ERK1 in nociceptors associated with ganglion cysts, dorsal root ganglion, hyperalgesia and nociceptor
17) Confidence 0.80 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.61 Pain Relevance 0.84
In addition, pressure rapidly increased the phosphorylation of p44/42 and p38 MAPK.
Phosphorylation (phosphorylation) of p44
18) Confidence 0.80 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.12 Pain Relevance 0.18
G. elata resulted in phosphorylation and dephosphorylation of ERK1/2 and JNK1/2-p38 MAPKs (members of the serine/threonine kinase family), respectively, as revealed by Western blot analysis.
Phosphorylation (phosphorylation) of ERK1
19) Confidence 0.80 Published 2004 Journal Life Sci. Section Abstract Doc Link 15261768 Disease Relevance 0.76 Pain Relevance 0.09
In a similar manner, phosphorylation of ERK1/2 was also decreased by these inhibitors.
Phosphorylation (phosphorylation) of ERK1
20) Confidence 0.80 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.65 Pain Relevance 0.91

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