INT72379

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Context Info
Confidence 0.74
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 2 96.52 Very High Very High Very High
Enkephalin 4 88.84 High High
MU agonist 1 87.84 High High
Calcium channel 2 79.84 Quite High
agonist 1 75.00 Quite High
Peripheral nervous system 2 18.96 Low Low
Hippocampus 1 11.36 Low Low
Central nervous system 2 6.48 Low Low
ischemia 8 5.04 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 22 90.92 High High
Atherosclerosis 12 85.48 High High
Disease 4 79.64 Quite High
Bordatella Infection 1 79.20 Quite High
Coronary Artery Disease 46 74.16 Quite High
Genetic Predisposition To Disease 2 73.88 Quite High
Stress 20 44.56 Quite Low
Targeted Disruption 5 30.80 Quite Low
Apoptosis 2 15.44 Low Low
Nervous System Malformation 1 6.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human Shc locus (Src homologous and collagen) encodes three proteins with relative molecular masses of 46K (p46Shc), 52K (p52Shc) and 66K (p66Shc).
Localization (masses) of p66Shc
1) Confidence 0.74 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.40 Pain Relevance 0
Moreover, it is the cooperation of both the SHC and the PLC?
Localization (cooperation) of SHC
2) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.04
The human Shc locus (Src homologous and collagen) encodes three proteins with relative molecular masses of 46K (p46Shc), 52K (p52Shc) and 66K (p66Shc).
Localization (masses) of p52Shc
3) Confidence 0.65 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.40 Pain Relevance 0
More limited modifications of the tyrosine phosphorylation status of the p46 and p66 forms of Shc were observed in parallel.
Localization (forms) of Shc
4) Confidence 0.45 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.08 Pain Relevance 0.45

General Comments

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