INT72380

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 6.87
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Anatomy Link Frequency
coronary artery 1
nerve 1
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 4 95.60 Very High Very High Very High
opioid receptor 2 91.32 High High
Angina 5 85.12 High High
MU agonist 1 82.64 Quite High
ischemia 60 80.52 Quite High
Calcium channel 4 79.84 Quite High
agonist 1 75.00 Quite High
Kinase C 7 54.64 Quite High
Inflammation 43 42.08 Quite Low
Peripheral nervous system 5 18.96 Low Low
Disease Link Frequency Relevance Heat
Aging 60 100.00 Very High Very High Very High
Breast Cancer 25 99.60 Very High Very High Very High
Coronary Artery Disease 124 99.44 Very High Very High Very High
Stress 82 99.08 Very High Very High Very High
Atherosclerosis 30 99.00 Very High Very High Very High
Apoptosis 190 98.48 Very High Very High Very High
Coronary Heart Disease 7 97.64 Very High Very High Very High
Disease 140 94.08 High High
Reperfusion Injury 17 92.00 High High
Death 71 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the recent observations that alterations in expression of p66Shc gene might be one possible cause in determining life span and in controlling oxidative stress, we hypothesised that sequence variations in p66Shc promoter may contribute to both aging and early atherogenesis.
Spec (may) Positive_regulation (contribute) of p66Shc associated with stress, aging and atherosclerosis
1) Confidence 0.69 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.85 Pain Relevance 0
We screened for new DNA polymorphisms the p66 specific region of the Shc locus (CH2) and the p66Shc promoter.
Positive_regulation (screened) of p66
2) Confidence 0.50 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.52 Pain Relevance 0
It has been reported that the p66Shc longevity gene increases intracellular reactive oxygen species (ROS), thereby affecting the rate of oxidative damage to nucleic acids [2].
Positive_regulation (increases) of p66Shc associated with aging
3) Confidence 0.50 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.45 Pain Relevance 0
The p66 specific region of the Shc locus and the p66Shc promoter were screened for new sequence variants in 78 subjects with early-onset coronary disease (<55 years, mean age 48.5 ± 6 year) recruited among subjects undergoing coronary angioplasty or presenting with clear evidence of CAD (previous diagnosis of MI, or one or more stenoses greater than 50% in at least one major coronary artery after coronary catheterisation and clinical symptoms of angina).
Positive_regulation (screened) of p66Shc in coronary artery associated with angina, pathologic constriction, coronary artery disease and coronary heart disease
4) Confidence 0.46 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.82 Pain Relevance 0.09
We screened for new DNA polymorphisms the p66 specific region of the Shc locus (CH2) and the p66Shc promoter and identified two very rare novel variants with no subject homozygous for these SNPs.
Positive_regulation (screened) of p66Shc
5) Confidence 0.46 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.59 Pain Relevance 0
Thus, nerve fiber targeting to the sensory epithelia mediated by BDNF [18] must use signalling mechanisms independent of the TrkB/SHC or PLC?
Neg (independent) Positive_regulation (independent) of SHC in nerve
6) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0
Moreover, it is the cooperation of both the SHC and the PLC?
Positive_regulation (cooperation) of SHC
7) Confidence 0.40 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.04
Epidermal growth factor caused some 10-12-fold enhancement of tyrosine phosphorylation of p52 Shc and marked increases in the p46 and p66 forms.
Positive_regulation (increases) of p52 Shc
8) Confidence 0.30 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.51
1-integrin and activation of Shc, ERK 1/2 and Sox-9.
Positive_regulation (activation) of Shc
9) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.31 Pain Relevance 0
The signaling pathways activated by PyV-mT include those of Ras, Shc, and phosphotidylinositol 3-kinase, which are frequently activated in human breast cancer (reviewed in [6]) and are also activated by ErbB2 (Her2/neu), a receptor tyrosine kinase that is overexpressed in 30% of breast cancer and is associated with poor outcome [7].
Positive_regulation (activated) of Shc associated with breast cancer
10) Confidence 0.08 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.87 Pain Relevance 0
FKHs proteins have also been found to be phosphorylated by a mechanism involving Jun N-terminal Kinase (JNK) and p66Shc during A?
Positive_regulation (involving) of p66Shc
11) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.82 Pain Relevance 0.03
Downstream signals after receptor activation include Shc, Crk and phospholipase C, and activation of phosphatidylinositol-3 (PI3) kinase.
Positive_regulation (activation) of Shc
12) Confidence 0.06 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 0.55 Pain Relevance 0.11

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