INT72384

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 0.48
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Anatomy Link Frequency
fibroblasts 2
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 99.98 Very High Very High Very High
Enkephalin 24 99.46 Very High Very High Very High
MU agonist 6 98.96 Very High Very High Very High
opioid receptor 12 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 6 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Positive_regulation (response) of Phosphorylation (phosphorylated) of p52 Shc associated with enkephalin
1) Confidence 0.32 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.08 Pain Relevance 0.51
Epidermal growth factor caused some 10-12-fold enhancement of tyrosine phosphorylation of p52 Shc and marked increases in the p46 and p66 forms.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of p52 Shc
2) Confidence 0.32 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.51
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Positive_regulation (response) of Phosphorylation (phosphorylated) of p52 Shc associated with enkephalin
3) Confidence 0.32 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.08 Pain Relevance 0.51
Epidermal growth factor caused some 10-12-fold enhancement of tyrosine phosphorylation of p52 Shc and marked increases in the p46 and p66 forms.
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of p52 Shc
4) Confidence 0.32 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.46
Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of shc associated with agonist and opioid receptor
5) Confidence 0.30 Published 1997 Journal Cell. Signal. Section Title Doc Link 9376223 Disease Relevance 0.07 Pain Relevance 0.53
Maximally effective concentrations of the opioid agonist D-ala2-D-leu5-enkephalin resulted in some 2-3-fold enhancement of tyrosine phosphorylation of the p52 Shc adapter protein in a clone of Rat-1 fibroblasts transfected to express stably the murine delta opioid receptor.
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of p52 Shc in fibroblasts associated with mu agonist, opioid receptor and enkephalin
6) Confidence 0.30 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.06 Pain Relevance 0.39

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