INT72385

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.62
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Anatomy Link Frequency
fibroblasts 1
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 34 99.92 Very High Very High Very High
agonist 18 99.62 Very High Very High Very High
opioid receptor 28 98.80 Very High Very High Very High
MU agonist 12 98.48 Very High Very High Very High
cytokine 29 92.32 High High
Inflammation 19 57.88 Quite High
Opioid 23 50.00 Quite Low
antagonist 14 27.32 Quite Low
substance P 2 12.00 Low Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 9 91.56 High High
Apoptosis 77 83.36 Quite High
Advanced Or Metastatic Breast Cancer 1 82.48 Quite High
Death 22 73.48 Quite High
Disease 21 72.48 Quite High
Hypersensitivity 16 72.12 Quite High
Breast Cancer 43 71.96 Quite High
Metastasis 18 71.28 Quite High
Adhesions 5 63.76 Quite High
INFLAMMATION 18 57.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More limited modifications of the tyrosine phosphorylation status of the p46 and p66 forms of Shc were observed in parallel.
Phosphorylation (phosphorylation) of Shc
1) Confidence 0.52 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.08 Pain Relevance 0.45
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Phosphorylation (phosphorylation) of p52 Shc associated with enkephalin
2) Confidence 0.52 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.53
Epidermal growth factor caused some 10-12-fold enhancement of tyrosine phosphorylation of p52 Shc and marked increases in the p46 and p66 forms.
Phosphorylation (phosphorylation) of p52 Shc
3) Confidence 0.52 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.46
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Phosphorylation (phosphorylated) of p52 Shc associated with enkephalin
4) Confidence 0.52 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.08 Pain Relevance 0.51
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Phosphorylation (phosphorylated) of p52 Shc associated with enkephalin
5) Confidence 0.52 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.08 Pain Relevance 0.51
Maximally effective concentrations of the opioid agonist D-ala2-D-leu5-enkephalin resulted in some 2-3-fold enhancement of tyrosine phosphorylation of the p52 Shc adapter protein in a clone of Rat-1 fibroblasts transfected to express stably the murine delta opioid receptor.
Phosphorylation (phosphorylation) of p52 Shc in fibroblasts associated with mu agonist, opioid receptor and enkephalin
6) Confidence 0.40 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.06 Pain Relevance 0.39
Half-maximal effects of D-ala2-D-leu5-enkephalin on p52 Shc tyrosine phosphorylation were produced with sub-nanomolar concentrations, in agreement with previous results on the tyrosine phosphorylation of p44MAPK (Burt et al., 1996). p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min.
Phosphorylation (phosphorylation) of p52 Shc associated with enkephalin
7) Confidence 0.40 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.09 Pain Relevance 0.53
Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor.
Phosphorylation (phosphorylation) of shc associated with agonist and opioid receptor
8) Confidence 0.40 Published 1997 Journal Cell. Signal. Section Title Doc Link 9376223 Disease Relevance 0.07 Pain Relevance 0.53
Furthermore, Tyr1173 (EGFR) is known to be involved in radio-resistance and has also been shown to phosphorylate key intracellular molecules like GAB1, SHC and PLC-?
Phosphorylation (phosphorylate) of SHC
9) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.30 Pain Relevance 0
Despite numerous reported differences, it does appear that diverse GPCRs share common mechanistic themes during ERK stimulation, including the tyrosine-phosphorylation of Shc and its complexing with Grb2, mSOS recruitment, the GTP-loading of Ras, and Raf-1 activation leading to MEK-1 phosphorylation [1].
Phosphorylation (phosphorylation) of Shc
10) Confidence 0.19 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0
-chain become phosphorylated.106 In general, the signaling events include the phosphorylation of tyrosine kinases, adapter proteins such as Shc and Grb-2, Ras-MAP kinase pathways, and janus kinase (Jak)-signal transducer and the activator of transcription (STAT) pathways (Fig. 2).
Phosphorylation (phosphorylation) of Shc
11) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.67 Pain Relevance 0.20

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