INT724

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2011
Negated 1
Speculated 5
Reported most in Abstract
Documents 151
Total Number 156
Disease Relevance 93.57
Pain Relevance 29.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
plasma 13
liver 13
blood 8
skin 4
body 4
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 123 100.00 Very High Very High Very High
depression 29 100.00 Very High Very High Very High
qutenza 14 100.00 Very High Very High Very High
halothane 32 99.98 Very High Very High Very High
Clonidine 14 99.98 Very High Very High Very High
agonist 12 99.98 Very High Very High Very High
local anesthetic 3 99.98 Very High Very High Very High
Somatostatin 4 99.94 Very High Very High Very High
addiction 6 99.92 Very High Very High Very High
Morphine 34 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 357 100.00 Very High Very High Very High
Pain 134 100.00 Very High Very High Very High
Weight Loss 120 100.00 Very High Very High Very High
Pressure And Volume Under Development 107 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 103 100.00 Very High Very High Very High
Hypertension 94 100.00 Very High Very High Very High
Body Weight 75 100.00 Very High Very High Very High
Coronary Artery Disease 56 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 46 100.00 Very High Very High Very High
Stroke 37 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adjuvant arthritis, as a model for investigating rheumatoid arthritis (RA), is characterized by reduced plasma albumin levels and interferes with drug binding in the plasma and tissues (liver and bone).
Negative_regulation (reduced) of albumin in liver associated with rheumatoid arthritis, experimental arthritis and arthritis
1) Confidence 0.59 Published 2005 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 16435567 Disease Relevance 0.66 Pain Relevance 0.52
Oleanolic acid protected the rat kidneys from gentamicin-induced nephrotoxicity as evident from a decrease in the serum and urine levels of creatinine, albumin and urea.
Negative_regulation (decrease) of albumin in urine associated with nephrotoxicity
2) Confidence 0.59 Published 2010 Journal Phytother Res Section Abstract Doc Link 19548288 Disease Relevance 0.34 Pain Relevance 0.08
RESULTS: As a result of a significant decrease in plasma albumin concentrations in arthritic rats, the unbound fraction of R- and S-ketoprofen was significantly increased (approximately 2-fold) in rats with adjuvant-induced arthritis.
Negative_regulation (decrease) of albumin in plasma
3) Confidence 0.59 Published 1999 Journal Pharm. Res. Section Body Doc Link 10450934 Disease Relevance 0.15 Pain Relevance 0
In animals subjected to the standardized intra-abdominal trauma, the pretreatment did not decrease the trauma-induced loss of albumin.
Negative_regulation (loss) of albumin associated with injury
4) Confidence 0.59 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1595342 Disease Relevance 0.51 Pain Relevance 0.32
In non-traumatized animals, pretreated rats had a higher loss of labelled albumin in calf muscle.
Negative_regulation (loss) of albumin in muscle
5) Confidence 0.59 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1595342 Disease Relevance 0.50 Pain Relevance 0.33
Albumin levels decrease in the IPC group (p=0.007), but the decline was not worse than the decline observed in the control group (p=0.329), and recovered rapidly after IPC removal.
Negative_regulation (decrease) of Albumin
6) Confidence 0.58 Published 2007 Journal Chest Section Body Doc Link 17890482 Disease Relevance 0.23 Pain Relevance 0
There was a significant decrease in body mass index (BMI) (P < .04), serum albumin level (P < .01), and World Health Organization (WHO) performance index (P < .02) at a 1-month evaluation.
Negative_regulation (decrease) of serum albumin in body
7) Confidence 0.58 Published 2006 Journal Gastrointest. Endosc. Section Body Doc Link 16996335 Disease Relevance 0.12 Pain Relevance 0
In the survivors, albumin levels were maintained; in the nonsurvivors, albumin levels decreased.
Negative_regulation (decreased) of albumin
8) Confidence 0.58 Published 1979 Journal J Am Geriatr Soc Section Abstract Doc Link 90687 Disease Relevance 0.30 Pain Relevance 0.09
The liver function might be slightly affected as indicated by minute increases in serum bilirubin and decreases in serum coagulation factors and albumin, but no other changes in liver function were observed.
Negative_regulation (decreases) of albumin in liver
9) Confidence 0.57 Published 1987 Journal Miner Electrolyte Metab Section Abstract Doc Link 3696093 Disease Relevance 0.14 Pain Relevance 0.04
Nonspecific laboratory findings such as leukocytosis, anemia, decreased albumin level, and thrombocytosis may be considered as supportive indicators.
Negative_regulation (decreased) of albumin associated with anaemia, leukocytosis and thrombosis related under development
10) Confidence 0.57 Published 1997 Journal J Emerg Med Section Abstract Doc Link 9017486 Disease Relevance 1.06 Pain Relevance 0.31
RESULTS: Lactate was increased and albumin was decreased in patients with acute liver failure compared to healthy controls resulting in normal net metabolic acid-base state.
Negative_regulation (decreased) of albumin in liver
11) Confidence 0.57 Published 2006 Journal J. Hepatol. Section Body Doc Link 16750869 Disease Relevance 0.17 Pain Relevance 0
The clinical course was severe with episodic remissions and recrudescences characterized by ascites (mild or moderate), elevation of bilirubin levels (mean: 1.1 mg/dl; range: 0.9-3.5 mg/dl), reduction of albumin levels (mean: 4 g/dl; range: 3.4-4.2 g/dl), and prolongation of elevated international normalized ratio (mean: 1; range: 0.9-1.4).
Negative_regulation (reduction) of albumin associated with pressure and volume under development and recurrence
12) Confidence 0.57 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18787474 Disease Relevance 1.48 Pain Relevance 0.08
A 33-year-old woman suffering from anal erosions developed severe illness with fever, diarrhea, ischalgia, hypotension, acute abdominal pain, dyspnea, renal and hepatic impairment, myalgia, desquamation of the skin, leukocytosis, anemia, hypocalcemia, decreased serum albumin, and cholesterol levels.
Negative_regulation (decreased) of serum albumin in skin associated with hypocalcemia, abdominal pain, diarrhoea, fever, myalgia, pressure volume 2 under development, anaemia, leukocytosis and dyspnea
13) Confidence 0.57 Published 1990 Journal Klin. Wochenschr. Section Abstract Doc Link 2197494 Disease Relevance 1.11 Pain Relevance 0.10
Plasma amylase activity was greatly increased together with a marked decrease in albumin.
Negative_regulation (decrease) of albumin in Plasma
14) Confidence 0.51 Published 1978 Journal Digestion Section Abstract Doc Link 738544 Disease Relevance 0.88 Pain Relevance 0.25
BV caused a detectable increase in blood creatine kinase, glutamic oxaloacetic transaminase, and lactic dehydrogenase, as well as a decrease in the blood total protein albumin and globulin levels.
Negative_regulation (decrease) of albumin in blood
15) Confidence 0.46 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 18543385 Disease Relevance 0.13 Pain Relevance 0.08
Interestingly, a significant decrease in exudated serum albumin was only shown in the subgroup of patients who had not previously reported single or repeated episodes of intolerance to contact lens wear.
Negative_regulation (decrease) of albumin in lens
16) Confidence 0.45 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2946994 Disease Relevance 0.24 Pain Relevance 0.04
RESULTS: Diclofenac caused the increase in intestinal permeability, enteric bacterial count, enteric protein and albumin loss and bacterial translocation.
Negative_regulation (loss) of albumin
17) Confidence 0.43 Published 2004 Journal Korean J Gastroenterol Section Body Doc Link 15564804 Disease Relevance 0 Pain Relevance 0
Serum albumin concentration was time-dependently decreased and correlated well with 3 major biologic determinants of drug clearance, hepatic blood flow (HBF), intrinsic clearance (CL(int)), and the unbound fraction of drugs in plasma (fp) after intravenous administration of cyclophosphamide, tolbutamide, zonisamide, and chlorzoxazone (as probe drugs for low hepatic extraction) and propranolol and lidocaine (as high-hepatic extraction drugs).
Negative_regulation (decreased) of Serum albumin in plasma associated with lidocaine
18) Confidence 0.43 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880627 Disease Relevance 0.26 Pain Relevance 0.09
Non-steroidal anti-inflammatory drugs such as flufenamic acid or phenylbutazone which are known to inhibit the hemolysis depending on their protein stabilizing activities inhibited both of the heat-induced hemolysis and albumin denaturation, but DSCG did not inhibit the albumin denaturation.
Negative_regulation (inhibit) of albumin associated with inflammation, hemolysis and cinod
19) Confidence 0.43 Published 1981 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 6172579 Disease Relevance 0.54 Pain Relevance 0.10
Lidocaine and SITS (4 acetamido-4-isothiocyano-stilbene-2,2-disulfonic acid disodium), two drugs that effectively reduce the albumin leakage in acute hypertension, had no prophylactic effect in cerebral air embolism.
Negative_regulation (reduce) of albumin associated with pressure and volume under development, decompression sickness, cva and lidocaine
20) Confidence 0.43 Published 1980 Journal Acta Neurol. Scand. Section Abstract Doc Link 6782818 Disease Relevance 0.78 Pain Relevance 0.30

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