INT72407

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.99
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
neuronal 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 100.00 Very High Very High Very High
fluoxetine 1 99.08 Very High Very High Very High
depression 3 96.00 Very High Very High Very High
Transcranial magnetic stimulation 1 92.36 High High
antagonist 11 89.28 High High
Serotonin 4 87.20 High High
Pain 2 82.76 Quite High
Neurotransmitter 2 79.36 Quite High
Inflammation 1 77.76 Quite High
antidepressant 1 62.44 Quite High
Disease Link Frequency Relevance Heat
Depression 3 96.00 Very High Very High Very High
Anxiety Disorder 2 90.96 High High
Pain 2 82.76 Quite High
Stress 2 82.40 Quite High
INFLAMMATION 1 77.76 Quite High
Obsessive-compulsive Disorder 1 68.80 Quite High
Tendinopathy 1 66.88 Quite High
Aggression 1 57.92 Quite High
Alcohol Addiction 1 57.44 Quite High
Cognitive Disorder 1 52.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously we have shown that in vitro, 5HT1A receptor binding to a radioactive agonist can be modulated by specific intensity and frequency electromagnetic fields (EMFs).
Regulation (modulated) of 5HT1A Binding (binding) of associated with agonist
1) Confidence 0.48 Published 2003 Journal Biomed Sci Instrum Section Abstract Doc Link 12724937 Disease Relevance 0.59 Pain Relevance 0.50
The importance of blockade of 5-HT 1B/D receptors in the raphé region, their possible interaction with 5-HT 1A receptors, and consequent inhibition of 5-HT release in terminal 5-HT 1B/D receptor-containing regions are discussed. 4.
Regulation (importance) of 5-HT 1A Binding (interaction) of
2) Confidence 0.44 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9378233 Disease Relevance 0.07 Pain Relevance 0.57
Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors: intrinsic activity and modulation by G-protein activation state.
Regulation (modulation) of 5-HT1A Binding (Interaction) of
3) Confidence 0.44 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9650800 Disease Relevance 0 Pain Relevance 0.14
When viewed in the light of our earlier results on the effect of cholesterol depletion on the serotonin1A receptor/G-protein interaction, these results comprehensively demonstrate the importance of cholesterol in the serotonin1A receptor function and form the basis for understanding lipid-protein interactions involving this important neuronal receptor.
Regulation (effect) of serotonin1A receptor Binding (interaction) of in neuronal
4) Confidence 0.15 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16005846 Disease Relevance 0.34 Pain Relevance 0.26

General Comments

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