INT72446

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.48
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
sympathetic 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 15 99.80 Very High Very High Very High
metalloproteinase 56 98.32 Very High Very High Very High
noradrenaline 5 89.96 High High
Angina 4 74.56 Quite High
psoriasis 1 70.28 Quite High
Percutaneous transluminal coronary angioplasty 1 69.96 Quite High
narcan 1 69.76 Quite High
Inflammation 9 48.00 Quite Low
fibrosis 1 41.28 Quite Low
alcohol 5 23.80 Low Low
Disease Link Frequency Relevance Heat
Disease 23 99.80 Very High Very High Very High
Coronary Heart Disease 1 96.04 Very High Very High Very High
Cancer 39 95.84 Very High Very High Very High
Peptic Ulcer 2 95.20 Very High Very High Very High
Hypertension 71 91.32 High High
Heart Rate Under Development 10 87.72 High High
Ulcers 14 85.28 High High
Proteinuria 12 84.60 Quite High
Natriuresis 2 84.16 Quite High
Obstructive Jaundice 1 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We are aware of no prior studies of the association between ACE inhibitors and PUD in humans, but Sugimoto et al. [27] suggested that ACE gene polymorphisms were associated with cancer risk and gastric ulcers in Japan.
Negative_regulation (inhibitors) of ACE Neg (no) Binding (association) of associated with cancer, peptic ulcer disease and peptic ulcer
1) Confidence 0.42 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.55 Pain Relevance 0.23
Intracoronary blockade of angiotensin-converting enzyme in humans: interaction with cardiac sympathetic neurotransmission?
Negative_regulation (blockade) of angiotensin-converting enzyme Binding (interaction) of in sympathetic
2) Confidence 0.41 Published 1997 Journal Acta Physiol. Scand. Section Title Doc Link 9381945 Disease Relevance 0.16 Pain Relevance 0.22
Other ACE inhibitor combinations
Negative_regulation (inhibitor) of ACE Binding (combinations) of
3) Confidence 0.35 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.45 Pain Relevance 0
Yamamoto and Takai have postulated that molecularinteraction between MMP-9 active sites and ACE inhibitors could brighten up the chances for MMP inhibitors for cardioprotection [35].
Negative_regulation (inhibitors) of ACE Binding (molecularinteraction) of
4) Confidence 0.07 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.32 Pain Relevance 0.17

General Comments

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