INT72468

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC) plasma membrane (OPRL1)
signal transducer activity (OPRL1)
OPRL1 (Homo sapiens)
PNOC (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 26 100.00 Very High Very High Very High
narcan 2 98.28 Very High Very High Very High
Morphine 2 98.08 Very High Very High Very High
opioid receptor 14 94.20 High High
antagonist 2 92.12 High High
agonist 2 91.48 High High
Kappa opioid receptor 2 48.64 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with dithiothreitol inhibited nociceptin binding to the ORL1 receptor.
Negative_regulation (inhibited) of ORL1 Binding (binding) of nociceptin associated with orphanin
1) Confidence 0.40 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.95
Morphine, naloxone, naltrindole, nor-Binaltorphimine and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) inhibited nociceptin binding to ORL1 receptor with Ki values of 36, 24, 0.4, 8 and 28 microM, respectively.
Negative_regulation (inhibited) of ORL1 Binding (binding) of nociceptin associated with orphanin, narcan and morphine
2) Confidence 0.29 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.87

General Comments

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