INT72474

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.76
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC)
Anatomy Link Frequency
nociceptors 1
ovary 1
PNOC (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 84 100.00 Very High Very High Very High
qutenza 10 100.00 Very High Very High Very High
Pain 9 100.00 Very High Very High Very High
nociceptor 6 100.00 Very High Very High Very High
alcohol 8 99.78 Very High Very High Very High
opioid receptor 27 99.60 Very High Very High Very High
analgesia 1 96.28 Very High Very High Very High
Analgesic 1 92.96 High High
Kappa opioid receptor 2 88.92 High High
algogenic 2 88.08 High High
Disease Link Frequency Relevance Heat
Nociception 18 100.00 Very High Very High Very High
Alcohol Addiction 6 98.72 Very High Very High Very High
Chromosome Duplication 1 90.60 High High
Pain 4 80.48 Quite High
Stress 2 77.88 Quite High
Anxiety Disorder 2 77.56 Quite High
Bordatella Infection 4 60.08 Quite High
Tetraploidy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings encourage the development of therapies targeted at the nociceptin system for the treatment of alcoholism in humans, though a minor number of studies showing continuous activation of the nociceptin receptor can produce increased, rather than reduced, alcohol consumption emphasize the necessity of further investigation.
Positive_regulation (activation) of nociceptin associated with alcohol addiction, orphanin and alcohol
1) Confidence 0.68 Published 2010 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 20201819 Disease Relevance 0.39 Pain Relevance 0.66
Overall, most, studies suggest that the endogenous nociceptin system has a physiological role in mediating or regulating behavioral responses to alcohol, and that activating nociceptin receptors suppresses ongoing alcohol consumption or reinstatement of responding for alcohol.
Positive_regulation (activating) of nociceptin associated with orphanin and alcohol
2) Confidence 0.45 Published 2010 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 20201819 Disease Relevance 0.41 Pain Relevance 0.70
Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors.
Positive_regulation (activation) of Nociceptin in ovary associated with orphanin and opioid receptor
3) Confidence 0.42 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.40
Nociceptin activation of ORL1 (opioid receptor-like 1 receptor) has been shown to antagonize mu receptor-mediated analgesia at the supraspinal level.
Positive_regulation (activation) of Nociceptin associated with orphanin, opioid receptor and analgesia
4) Confidence 0.30 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.08 Pain Relevance 0.47
The fourth peptide gene most likely arose by a local duplication resulting in PNOC and POMC.
Positive_regulation (resulting) of PNOC
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2865548 Disease Relevance 0.09 Pain Relevance 0.18
Following incubation with nociceptin mitogen-activated protein kinase activity was increased by 2-fold in cells expressing the ORL1 receptor.
Positive_regulation (increased) of nociceptin associated with orphanin
6) Confidence 0.24 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.55
Orphanin FQ2 (OFQ2) is a novel heptadecapeptide generated from prepronociceptin (PPNOC), the same precursor of nociceptin/orphanin FQ and nocistatin.
Positive_regulation (generated) of prepronociceptin associated with orphanin
7) Confidence 0.21 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10812065 Disease Relevance 0.07 Pain Relevance 0.35
Nociceptin/orphanin FQ (N/OFQ), nocistatin, and prepro-N/OFQ 160-187 (C-peptide) are all derived from the same precursor protein.
Positive_regulation (derived) of nocistatin associated with orphanin
8) Confidence 0.06 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12665541 Disease Relevance 0.23 Pain Relevance 0.51
Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.
Positive_regulation (activation) of Nocistatin in nociceptors associated with nociception, qutenza, nociceptor and orphanin
9) Confidence 0.06 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12665541 Disease Relevance 0.49 Pain Relevance 1.02

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