INT72482

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Context Info
Confidence 0.24
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 9.06
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ANTXR2) endoplasmic reticulum (ANTXR2) plasma membrane (ANTXR2)
Anatomy Link Frequency
blood 2
neuronal 1
ANTXR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 78 98.08 Very High Very High Very High
dopamine receptor 3 88.44 High High
ischemia 56 86.64 High High
Enkephalin 1 79.96 Quite High
cva 21 64.88 Quite High
Neuropeptide 4 64.88 Quite High
Neurotransmitter 3 61.28 Quite High
Catecholamine 9 51.00 Quite High
gABA 1 50.24 Quite High
Substantia nigra 1 41.48 Quite Low
Disease Link Frequency Relevance Heat
Hypertension 1246 100.00 Very High Very High Very High
Stroke 161 95.12 Very High Very High Very High
Cardiovascular Disease 105 92.00 High High
Heart Rate Under Development 63 86.96 High High
Coronary Artery Disease 84 86.64 High High
Sleep Disorders 69 84.84 Quite High
Disease 32 82.24 Quite High
Targeted Disruption 43 80.24 Quite High
Coronary Heart Disease 126 77.32 Quite High
Myocardial Infarction 35 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tamborini et al. [133], noted not only the significant reduction of systemic blood pressure in the uncontrolled ISH but also a decrease in the coronary blood flow during induction of anesthesia.
Negative_regulation (decrease) of ISH in blood associated with anesthesia and hypertension
1) Confidence 0.24 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.21 Pain Relevance 0.27
Tamborini et al. [133], noted not only the significant reduction of systemic blood pressure in the uncontrolled ISH but also a decrease in the coronary blood flow during induction of anesthesia.
Negative_regulation (reduction) of ISH in blood associated with anesthesia and hypertension
2) Confidence 0.24 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.21 Pain Relevance 0.27
This led to a significant proportion of ISH patients being missed from the old perioperative hypertensive studies.
Negative_regulation (proportion) of ISH associated with hypertension
3) Confidence 0.24 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.32 Pain Relevance 0.14
However, when ISH is coupled to ICC on a same section, a loss of signal in ISH is often observed (Siegel, R.E., Localization of neuronal mRNAs by hydridization histochemistry.
Negative_regulation (loss) of ISH in neuronal
4) Confidence 0.23 Published 1997 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 9385084 Disease Relevance 0 Pain Relevance 0.31
Epidemiology of ISH
Negative_regulation (Epidemiology) of ISH associated with hypertension
5) Confidence 0.21 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.13 Pain Relevance 0
The prevalence of ISH increases with age, and it accounts for substantial proportion of hypertensive patients.
Negative_regulation (prevalence) of ISH associated with hypertension
6) Confidence 0.21 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.14 Pain Relevance 0
The significance of perioperative ISH, however, is not well studied, partly due to its recognition only fairly recently as a cardiovascular risk factor in the non-surgical setting, and partly due to the evolving definition of ISH.
Negative_regulation (definition) of ISH associated with hypertension
7) Confidence 0.21 Published 2008 Journal Current Cardiology Reviews Section Abstract Doc Link PMC2774582 Disease Relevance 1.48 Pain Relevance 0.03
ISH is currently defined as SBP > 140 mmHg with DBP < 90 mmHg, and not secondary to another disorder in individuals aged 18 and older.
Negative_regulation (defined) of ISH associated with hypertension
8) Confidence 0.21 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.29 Pain Relevance 0
A combination of ISH and immunostaining showed Igfbp3 expression in a majority (?
Negative_regulation (combination) of ISH
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.28 Pain Relevance 0

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