INT72483

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 15
Total Number 24
Disease Relevance 16.09
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ANTXR2) endoplasmic reticulum (ANTXR2) plasma membrane (ANTXR2)
Anatomy Link Frequency
blood 1
pore 1
heart 1
ANTXR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 27 98.52 Very High Very High Very High
Potency 16 96.22 Very High Very High Very High
dopamine receptor 3 96.12 Very High Very High Very High
Enkephalin 1 87.64 High High
Central nervous system 9 76.00 Quite High
Neuropeptide 1 72.56 Quite High
Neurotransmitter 2 68.96 Quite High
ischemia 72 63.24 Quite High
Catecholamine 10 58.68 Quite High
gABA 1 57.92 Quite High
Disease Link Frequency Relevance Heat
Hypertension 1619 100.00 Very High Very High Very High
Syndrome 9 100.00 Very High Very High Very High
Stroke 209 99.80 Very High Very High Very High
Poisoning 231 98.76 Very High Very High Very High
Cv General 3 Under Development 28 98.52 Very High Very High Very High
Aging 65 96.52 Very High Very High Very High
Renal Disease 18 96.52 Very High Very High Very High
Pressure And Volume Under Development 142 95.52 Very High Very High Very High
Myocardial Infarction 46 92.08 High High
Bacillus Anthracis Infection 317 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, data from the Framingham Study show that ISH was associated not only with increased mortality but also cardiovascular morbidity.
ISH Binding (associated) of associated with hypertension
1) Confidence 0.35 Published 1998 Journal J Hum Hypertens Section Abstract Doc Link 9783491 Disease Relevance 1.37 Pain Relevance 0
ISH is strongly associated with increased risks of cardiac and cerebrovascular events exceeding those in comparably aged individuals with diastolic hypertension.
ISH Binding (associated) of associated with pressure and volume under development, hypertension and cva
2) Confidence 0.27 Published 2008 Journal Current Cardiology Reviews Section Abstract Doc Link PMC2774582 Disease Relevance 1.37 Pain Relevance 0.05
The only study looking at the association between ISH and postoperative cardiovascular events was carried out in the open-heart surgery patients [100].
ISH Binding (association) of in heart associated with hypertension
3) Confidence 0.27 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.39 Pain Relevance 0.15
Data from clinical studies indicate that ISH is a distinct syndrome with pathophysiological changes different from those in essential hypertension [23].
ISH Binding (syndrome) of associated with syndrome and hypertension
4) Confidence 0.21 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.33 Pain Relevance 0
Although well conducted at the time, we believe that these early studies failed to recognize ISH as a perioperative risk factor for the following reasons.
ISH Neg (failed) Binding (recognize) of associated with hypertension
5) Confidence 0.21 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.18 Pain Relevance 0
For decades, ISH was not deemed to be strongly associated with the same sequelae as in diastolic or combined hypertension [67,91,92].
ISH Binding (associated) of associated with hypertension
6) Confidence 0.21 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.17 Pain Relevance 0
Several studies have shown the strong association between ISH and stroke, cardiovascular morbidity and mortality [3-5].
ISH Binding (association) of associated with stroke and hypertension
7) Confidence 0.20 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 0.78 Pain Relevance 0
Combination of ISH and ICC allows the simultaneous detection of specific mRNAs and antigens in a same section or in adjacent sections.
ISH Binding (Combination) of
8) Confidence 0.20 Published 1997 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 9385084 Disease Relevance 0 Pain Relevance 0.35
The significance of perioperative ISH, however, is not well studied, partly due to its recognition only fairly recently as a cardiovascular risk factor in the non-surgical setting, and partly due to the evolving definition of ISH.
ISH Binding (recognition) of associated with hypertension
9) Confidence 0.18 Published 2008 Journal Current Cardiology Reviews Section Abstract Doc Link PMC2774582 Disease Relevance 1.52 Pain Relevance 0.04
Individuals may have undiagnosed ISH for years without having had their blood pressure checked.
ISH Binding (undiagnosed) of in blood associated with hypertension
10) Confidence 0.18 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.24 Pain Relevance 0
Isolated Systolic Hypertension (ISH) is increasingly recognized as a cardiovascular risk [1,2].
ISH Binding (recognized) of associated with hypertension
11) Confidence 0.18 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 0.71 Pain Relevance 0
The soluble, monomeric ANTXR2 VWA domain (sANTXR2), expressed and purified from mammalian cells, was previously shown to effectively block entry of LeTx into susceptible cells by competing with cellular ANTXR2 for binding to PA [10].
ANTXR2 Binding (binding) of
12) Confidence 0.16 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC2000967 Disease Relevance 0.16 Pain Relevance 0
Given the exceptionally tight binding of PA to ANTXR2 under natural conditions (Kd = 170 pM) [21], we reasoned that complexes formed between chimera 264 and PA would be sufficiently stable to serve as an immunogen in vivo.
ANTXR2 Binding (binding) of
13) Confidence 0.16 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC2000967 Disease Relevance 0.43 Pain Relevance 0
While the potency of the nanoparticles as a vaccine is most likely due to polyvalent display of PA, polyvalency is less of a factor in the function of the particles as an antitoxin given the extremely high affinity between PA and ANTXR2.
ANTXR2 Binding (affinity) of associated with potency
14) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC2000967 Disease Relevance 0.20 Pain Relevance 0.05
The soluble, monomeric ANTXR2 VWA domain (sANTXR2), expressed and purified from mammalian cells, was previously shown to effectively block entry of LeTx into susceptible cells by competing with cellular ANTXR2 for binding to PA [10].
ANTXR2 Binding (competing) of
15) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC2000967 Disease Relevance 0.16 Pain Relevance 0
To address the possible role of ANTXR2 in lethal toxin killing of Fischer 344 rats, we first confirmed that D683 mutant forms of PA can interact with rat ANTXR2 (rANTXR2) but not rat ANTXR1.
ANTXR2 Neg (not) Binding (interact) of
16) Confidence 0.07 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.33 Pain Relevance 0
The ANTXR2 I domain binds to PA domains 2 and 4, and the surface area of the protein interface is much larger (approximately 2,000 Å2) than that of ?
ANTXR2 Binding (binds) of
17) Confidence 0.07 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.58 Pain Relevance 0
The large contact surface correlates with a very tight ANTXR2 I domain–PA binding affinity (KD = 170 or 780 pM in Mg2+ or Ca2+, respectively) [35], compared with the affinity of ?
ANTXR2 Binding (affinity) of
18) Confidence 0.07 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.46 Pain Relevance 0
When the PA heptamer is bound to ANTXR2, a pH value of approximately 5.0 is required to allow efficient pore formation, whereas approximately pH 6 is required for PA pore formation when the toxin is bound to ANTXR1 [20,37].
ANTXR2 Binding (bound) of in pore
19) Confidence 0.07 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.06 Pain Relevance 0
The differential ability of ANTXR1 and ANTXR2 to bind D683 mutant PA proteins was mapped to nonconserved receptor residues at the binding interface with PA domain 2.
ANTXR2 Binding (bind) of
20) Confidence 0.07 Published 2006 Journal PLoS Pathogens Section Abstract Doc Link PMC1617126 Disease Relevance 0.59 Pain Relevance 0

General Comments

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