INT725

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Context Info
Confidence 0.41
First Reported 1978
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 62
Total Number 63
Disease Relevance 37.21
Pain Relevance 8.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B19 2
spleen 2
eye 2
B cells 2
plasma 1
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 100.00 Very High Very High Very High
Morphine 12 99.88 Very High Very High Very High
anesthesia 21 99.74 Very High Very High Very High
cytokine 90 99.52 Very High Very High Very High
halothane 2 99.52 Very High Very High Very High
methotrexate 68 99.48 Very High Very High Very High
Pain 50 99.46 Very High Very High Very High
dexamethasone 7 99.38 Very High Very High Very High
Spinal cord 78 99.20 Very High Very High Very High
Etanercept 141 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bullous Skin Disease 304 100.00 Very High Very High Very High
Depression 1 100.00 Very High Very High Very High
Immunodeficiency 26 99.76 Very High Very High Very High
Disease 719 99.70 Very High Very High Very High
Agammaglobulinemia 55 99.68 Very High Very High Very High
Acantholysis 65 99.64 Very High Very High Very High
Targeted Disruption 59 99.64 Very High Very High Very High
Autoimmune Disease 65 99.50 Very High Very High Very High
Pain 37 99.46 Very High Very High Very High
Neuromyelitis Optica 272 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some patients may develop specific IgG without developing disease and some will lose their specific IgG during their lifetime.
Negative_regulation (lose) of IgG associated with disease
1) Confidence 0.41 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.72 Pain Relevance 0
These include the need for intramuscular administration, pain at the site of injection, loss of immunoglobulin G (IgG) extravascularly, limitations on the degree to which serum IgG can be increased, incomplete and delayed onset of absorption, and limitations on the volume of material administered.
Negative_regulation (loss) of IgG associated with pain
2) Confidence 0.41 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3118708 Disease Relevance 0.29 Pain Relevance 0.10
Morphine also inhibited CT-specific IgA and IgG levels in serum.
Negative_regulation (inhibited) of IgG associated with morphine
3) Confidence 0.39 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11564781 Disease Relevance 0.31 Pain Relevance 1.03
Accordingly, laser photocoagulation of the retina upregulated FcRn expression and resulted in a more rapid elimination of IgG from the eye into the systemic circulation.


Negative_regulation (elimination) of IgG in eye
4) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2794657 Disease Relevance 0.23 Pain Relevance 0
Myeloma typing revealed IgG myeloma in 10 cases, light chain myeloma in 3 cases and IgA myeloma in one case.
Negative_regulation (revealed) of IgG
5) Confidence 0.34 Published 2005 Journal Indian J Pathol Microbiol Section Abstract Doc Link 16761740 Disease Relevance 0.60 Pain Relevance 0.17
In this study the prevalence of both IgG and IgA C1qAb was assessed in serum samples of 385 patients with different systemic and renal diseases.
Negative_regulation (prevalence) of IgG associated with renal disease
6) Confidence 0.31 Published 1992 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 1348021 Disease Relevance 1.00 Pain Relevance 0.07
The results demonstrate that the prevalence of IgG and IgA C1qAb is not restricted to the diseases in which they were originally described.
Negative_regulation (prevalence) of IgG associated with disease
7) Confidence 0.31 Published 1992 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 1348021 Disease Relevance 1.11 Pain Relevance 0.09
Recently, IgG was detected in the perikarya of motor neurons of the lumbar spinal cord in mice 24 hours after intraperitoneal injection of IgG derived from sera of ALS patients [31].
Negative_regulation (injection) of IgG in spinal cord associated with motor neuron diseases and spinal cord
8) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.61 Pain Relevance 0.24
Intravitreally administered full-length IgG distribution in FcRn knockout and wild-type mouse eyes
Negative_regulation (distribution) of IgG in eyes associated with targeted disruption
9) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2794657 Disease Relevance 0.26 Pain Relevance 0
Interestingly, IgG was eliminated across the blood-retinal barrier into the blood system in the normal retina, whereas IgY was not.
Negative_regulation (eliminated) of IgG in retina
10) Confidence 0.28 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2794657 Disease Relevance 0.17 Pain Relevance 0
A small but significant reduction in circulating RF-IgM, anti-CCP IgG, and total IgM, but not total IgG, was observed (Figure 6a).
Negative_regulation (reduction) of IgG
11) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.07 Pain Relevance 0
The results showed that treatment with indomethacin was followed by decreases in OVA-specific IgG and proliferation of spleen cells to the antigen.
Negative_regulation (decreases) of IgG in spleen
12) Confidence 0.22 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.32 Pain Relevance 0.35
However, in synovia containing lymphoid aggregates, substantial and significant reductions of total IgM and IgG were noted in response to rituximab, whether assayed by constant region mRNA levels (Figure 7a) or by protein content (Figure 7b).
Negative_regulation (reductions) of IgG
13) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.23 Pain Relevance 0.03
10) or 400 ng rabbit IgG/SAP conjugate (N?
Negative_regulation (rabbit) of IgG
14) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2519834 Disease Relevance 0 Pain Relevance 0.14
Accelerated catabolism of IgG is found when the FcRn in states of hypergammaglobulinemia is saturated.
Negative_regulation (catabolism) of IgG associated with hypergammaglobulinemia
15) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.92 Pain Relevance 0.14
Treatments with IND, DEX, MTX and AUR were followed by decreases in OVA-specific IgG and proliferation of spleen cells to the antigen.
Negative_regulation (decreases) of IgG in spleen associated with methotrexate and dexamethasone
16) Confidence 0.18 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.43 Pain Relevance 0.48
The consequence of this interaction was the inhibition of IgG-mediated phagocytosis of C. neoformans by alveolar macrophages.
Negative_regulation (inhibition) of IgG in alveolar macrophages
17) Confidence 0.17 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2147053 Disease Relevance 0.65 Pain Relevance 0.04
Despite the significant effect on total immunoglobulin content in aggregate-containing synovia, neither RF-IgM nor anti-CCP IgG in synovial tissues were decreased by rituximab, whether they contained lymphoid aggregates or not (Figure 7c).


Neg (not) Spec (whether) Negative_regulation (decreased) of IgG
18) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.26 Pain Relevance 0.04
A small but significant reduction in circulating RF-IgM, anti-CCP IgG, and total IgM, but not total IgG, was observed (Figure 6a).
Negative_regulation (reduction) of IgG
19) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.06 Pain Relevance 0
Immunization by the nasal route induced a strong IgG response that was reduced by an average of 25% in the presence of pre-existing immunity.
Negative_regulation (reduced) of IgG in nasal associated with immunization
20) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.62 Pain Relevance 0

General Comments

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