INT72523

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 3.19
Pain Relevance 7.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TCEA1) nucleolus (TCEA1) nucleus (TCEA1)
DNA binding (TCEA1)
Anatomy Link Frequency
SII 3
anterior 2
neurons 2
Plasma 1
insular cortex 1
TCEA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 141 100.00 Very High Very High Very High
Somatosensory cortex 85 100.00 Very High Very High Very High
Pain 60 99.82 Very High Very High Very High
cerebral cortex 4 99.64 Very High Very High Very High
Thalamus 7 97.24 Very High Very High Very High
Acupuncture 1 96.00 Very High Very High Very High
Pain threshold 2 95.96 Very High Very High Very High
qutenza 15 95.72 Very High Very High Very High
analgesia 1 95.52 Very High Very High Very High
electroacupuncture 6 92.28 High High
Disease Link Frequency Relevance Heat
Pain 32 99.82 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 95 99.62 Very High Very High Very High
Epilepsy 2 93.88 High High
Neuropathic Pain 7 89.44 High High
Nociception 4 80.80 Quite High
Urological Neuroanatomy 1 77.92 Quite High
Peripheral Arterial Disease 97 50.96 Quite High
INFLAMMATION 47 50.00 Quite Low
Complex Regional Pain Syndromes 4 50.00 Quite Low
Hyperalgesia 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clusters reveal a distinct differentiation in the population of SII neurons to the different stimulus conditions.
Regulation (population) of SII in neurons
1) Confidence 0.45 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0
To directly compare the time course of the response of the anterior and posterior regions of SII to the three stimulus conditions, we determined the time course of the absorbance changes in each region under each stimulus condition (Figure 4).
Regulation (response) of SII in anterior
2) Confidence 0.39 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0
Previously, we postulated that SII activity levels modulated the SI response when the SII activity was evoked by vibratory stimuli [18].
Regulation (modulated) of SII associated with primary somatosensory cortex
3) Confidence 0.27 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0.05 Pain Relevance 0.37
Although an influence mediated via direct callosal projections from ipsilateral SI to contralateral SI [2] should not be ruled out, the data presented in this study lead us to propose that SII is the major source of the modulated SI response to contralateral skin stimulation that is observed under a variety of stimulus conditions [16-19].
Regulation (modulated) of SII in skin associated with primary somatosensory cortex
4) Confidence 0.27 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0 Pain Relevance 0.41
These results corroborate the notion that SII is the target of independent pathways for the processing and integration of nonpainful and painful somatosensory stimuli salient for further high-order elaborations.
Regulation (target) of SII in SII associated with pain and somatosensory cortex
5) Confidence 0.26 Published 2008 Journal Neuroimage Section Abstract Doc Link 18329293 Disease Relevance 0 Pain Relevance 0.84
SII responses were compared to those from adjacent SI and insular cortex.
Regulation (responses) of SII in insular cortex
6) Confidence 0.24 Published 2006 Journal Cereb. Cortex Section Abstract Doc Link 16177270 Disease Relevance 0.34 Pain Relevance 0.45
SII responses were able to encode gradually the intensity of stimuli from sensory threshold up to a level next to pain threshold but tended to show a ceiling effect for higher painful intensities.
Regulation (responses) of SII associated with pain and pain threshold
7) Confidence 0.24 Published 2007 Journal Cereb. Cortex Section Abstract Doc Link 16614165 Disease Relevance 0.26 Pain Relevance 0.45
Instead, the gating effects on bilateral SII activity were stronger after simultaneous bimodal when compared to unimodal stimulations.
Regulation (effects) of SII in SII associated with somatosensory cortex
8) Confidence 0.24 Published 2003 Journal Neuroimage Section Abstract Doc Link 14642480 Disease Relevance 0.06 Pain Relevance 0.93
Capsaicin pain, which had no concomitant tactile component, produced little or no activation in secondary somatosensory cortex (SII), whereas light brushing produced a prominent activation of SII, suggesting a differential sensitivity of SII to tactile versus painful stimuli.
Regulation (sensitivity) of SII in SII associated with somatosensory cortex, pain and qutenza
9) Confidence 0.24 Published 1998 Journal Brain Section Abstract Doc Link 9619195 Disease Relevance 1.18 Pain Relevance 2.38
On the other hand, Bennett et al. [19] found that bilateral convergence on SII neurons varies markedly with the different classes of tactile neurons, and modulation of the SII response by ipsilateral inputs may vary from one cortical area to another with different stimulus modalities.
Regulation (modulation) of SII in neurons
10) Confidence 0.24 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0.04
In contrast to selective attention, which enhances pain ratings by increasing sensory gain, emotions triggered by seeing other people's pain did not alter processing in SI-SII (primary and second somatosensory areas), but may have biased the transfer to, and the representation of pain in short-term memory buffers (prefrontal), as well as the affective assignment to this representation (temporal pole).
Neg (not) Regulation (alter) of SI-SII in pole associated with pain
11) Confidence 0.24 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17079675 Disease Relevance 0.69 Pain Relevance 0.77
The negative correlation indicates that the time course of stimulus-evoked activity in SI and anterior SII is trending in a direction opposite to that observed under the contralateral stimulus condition, whereas in posterior SII the activity modifies in a manner similar to that observed in the responding region of SI.
Regulation (modifies) of SII in posterior
12) Confidence 0.23 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0 Pain Relevance 0
Humans who have their corpus callosum sectioned as part of surgical procedures show reduced or eliminated ipsilateral responses in SII and parietal areas 2 and 5 [58].
Regulation (responses) of SII in parietal
13) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734169 Disease Relevance 0 Pain Relevance 0.08
No change was present within SI, SII, and the anterior cingulate cortex.
Neg (No) Regulation (change) of SII in anterior
14) Confidence 0.14 Published 1999 Journal Neurology Section Body Doc Link 10449119 Disease Relevance 0 Pain Relevance 0
To directly compare the time course of the response of the anterior and posterior regions of SII to the three stimulus conditions, we determined the time course of the absorbance changes in each region under each stimulus condition (Figure 4).
Regulation (response) of SII in posterior regions
15) Confidence 0.13 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0
Major findings included a marked reduction in the duration of beta rebound in the ADHD group compared to controls in both SI and SII.
Regulation (controls) of SII associated with somatosensory cortex, primary somatosensory cortex and attention deficit hyperactivity disorder
16) Confidence 0.10 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.56 Pain Relevance 0.47
In order to probe into whether beta-endorphin is involved in descending modulation of the somatosensory area (SII) of the cerebral cortex on the nucleus centrum medianum (CM) of the thalamus and this mechanism of acupuncture analgesia, it was investigated that effects of electrical stimulation of SII and electroacupuncture on beta-endorphin content in the perfusate from the nucleus CM.
Spec (whether) Regulation (modulation) of SII in thalamus associated with acupuncture, thalamus, electroacupuncture, cerebral cortex and analgesia
17) Confidence 0.10 Published 1996 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 9388314 Disease Relevance 0 Pain Relevance 0.40
As the SII and PPC responses were not enhanced in the CRPS patients, other brain areas are likely to contribute to the observed hyperesthesia to pain.
Neg (not) Regulation (responses) of SII in brain
18) Confidence 0.02 Published 2008 Journal Clin Neurophysiol Section Body Doc Link 18723393 Disease Relevance 0.05 Pain Relevance 0
Plasma concentrations of sTF, sTM and D-D were analyzed using commercially available IMUBIND quantitative ELISA kits according to the manufacturer's instructions (American Diagnostica Inc, Stamford, CI).
Spec (analyzed) Regulation (concentrations) of sTF in Plasma
19) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0 Pain Relevance 0

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