INT7253

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 70
Total Number 76
Disease Relevance 21.06
Pain Relevance 20.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
neural 10
stomach 8
nerves 4
ENS 4
plasma 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 290 100.00 Very High Very High Very High
Cholecystokinin 40 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
antagonist 63 99.98 Very High Very High Very High
electroacupuncture 6 99.60 Very High Very High Very High
Calcitonin gene-related peptide 90 99.54 Very High Very High Very High
qutenza 39 99.06 Very High Very High Very High
Inflammation 33 99.04 Very High Very High Very High
narcan 11 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 139 100.00 Very High Very High Very High
Cancer 40 100.00 Very High Very High Very High
Fasciitis 6 100.00 Very High Very High Very High
Duodenal Ulcer 33 99.84 Very High Very High Very High
Gastrinoma 13 99.74 Very High Very High Very High
INFLAMMATION 37 99.62 Very High Very High Very High
Peptic Ulcer 8 99.56 Very High Very High Very High
Rheumatic Fever 3 99.28 Very High Very High Very High
Syndrome 22 99.00 Very High Very High Very High
Injury 6 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This bombesin-antagonist completely reduced distention-stimulated gastrin release in vivo.
Negative_regulation (reduced) of Localization (release) of gastrin associated with antagonist
1) Confidence 0.59 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.31
In contrast distention of the isolated rat stomach inhibits gastrin release in part via intrinsic cholinergic pathways and other as yet unknown mechanisms.
Negative_regulation (inhibits) of Localization (release) of gastrin in stomach
2) Confidence 0.59 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.16
Distention-induced decrease of gastrin release was attenuated to 50 percent by atropine (10(-7) M: n = 10) or tetrodotoxin (TTX) (10(-6) M; n = 10), respectively.
Negative_regulation (decrease) of Localization (release) of gastrin associated with tetrodotoxin
3) Confidence 0.59 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.29
In contrast, distention of the isolated, extrinsically denervated stomach significantly decreased gastrin release by 13+/-5 pg/min (5 ml saline, n = 8, P < 0.05), 28+/-8 pg/min (10 ml saline, n = 11, P < 0.05) and 35+/-10 pg/min (15 ml saline, n = 8, P < 0.01), respectively, without changing the activity of bombesin/GRP-neurons.
Negative_regulation (decreased) of Localization (release) of gastrin in neurons
4) Confidence 0.59 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.30
Some of these tumours are probably the consequence of massive hypergastrinaemia due to alkaline gastric pH and consequent lack of inhibition of gastrin release.
Negative_regulation (inhibition) of Localization (release) of gastrin associated with cancer
5) Confidence 0.59 Published 1985 Journal Schweiz Med Wochenschr Suppl Section Abstract Doc Link 2865808 Disease Relevance 0.67 Pain Relevance 0.08
Intraluminal perfusion with alkaline solutions (0.1 M NaHCO3) increased gastrin secretion, whereas perfusion with acid solutions (pH 3.5-3.0) inhibited gastrin secretion.
Negative_regulation (inhibited) of Localization (secretion) of gastrin
6) Confidence 0.59 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.24
A nervous mechanism involving acetylcholine was further suggested by the inhibitory action of methionine-enkephalin on gastrin release after vagal section.
Negative_regulation (action) of Localization (release) of gastrin associated with enkephalin
7) Confidence 0.58 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6148016 Disease Relevance 0 Pain Relevance 0.15
The inhibitory action of galanin on gastrin secretion was also present during the infusion of tetrodotoxin suggesting that this effect is not mediated via neural pathways.
Negative_regulation (action) of Localization (secretion) of gastrin in neural associated with tetrodotoxin
8) Confidence 0.58 Published 1988 Journal Life Sci. Section Abstract Doc Link 2453773 Disease Relevance 0 Pain Relevance 0.24
The present data demonstrate that galanin is an inhibitor of basal and stimulated gastrin secretion and has to be considered as an inhibitory neurotransmitter which could participate in the regulation of gastric G-cell function.
Negative_regulation (inhibitor) of Localization (secretion) of gastrin associated with neurotransmitter
9) Confidence 0.58 Published 1988 Journal Life Sci. Section Abstract Doc Link 2453773 Disease Relevance 0 Pain Relevance 0.24
We conclude that the antisecretory effects of electroacupuncture do not result from decreased gastrin release or decreased parietal cell sensitivity to gastrin, but are mediated through naloxone-sensitive opioid neural pathways and vagal efferent pathways.
Negative_regulation (decreased) of Localization (release) of gastrin in neural associated with narcan, opioid and electroacupuncture
10) Confidence 0.58 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1345034 Disease Relevance 0 Pain Relevance 0.60
The drug Milid does not change the serum gastrin level but suppresses the gastrin secretion in the gastric juice.
Negative_regulation (suppresses) of Localization (secretion) of gastrin in gastric juice
11) Confidence 0.58 Published 1989 Journal Vutr Boles Section Abstract Doc Link 2741440 Disease Relevance 0.87 Pain Relevance 0.07
In patients with normogastrinaemic duodenal ulcer disease the feedback mechanism between gastric acid and gastrin secretion is impaired, while in gastric ulcer patients gastrin secretion is appropriately regulated by gastric acid.
Negative_regulation (impaired) of Localization (secretion) of gastrin associated with duodenal ulcer and peptic ulcer
12) Confidence 0.54 Published 1988 Journal Drugs Section Abstract Doc Link 3061768 Disease Relevance 0.62 Pain Relevance 0.20
Gastrin secretion is highly dependent upon gastric intraluminal pH and is inhibited significantly by a pH of less than 3.0.
Negative_regulation (inhibited) of Localization (secretion) of Gastrin
13) Confidence 0.54 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1676713 Disease Relevance 0 Pain Relevance 0.11
Vagotomy and atropinization abolished the release of gastrin and CCK in response to all three stimuli.
Negative_regulation (abolished) of Localization (release) of gastrin associated with cholecystokinin
14) Confidence 0.54 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1362318 Disease Relevance 0 Pain Relevance 0.52
Potent antisecretory drugs, such as omeprazole, increase serum and antral gastrin and reduce antral somatostatin, whereas certain prostaglandin E2 analogues inhibit serum gastrin secretion after feeding.
Negative_regulation (inhibit) of Localization (secretion) of gastrin associated with somatostatin
15) Confidence 0.54 Published 1988 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2906469 Disease Relevance 0.64 Pain Relevance 0.17
These results indicate that one mechanism by which urethane induced low basal gastric acid secretion involved increased synthesis and release of endogenous somatostatin and associated inhibition of gastrin secretion.
Negative_regulation (inhibition) of Localization (secretion) of gastrin associated with somatostatin
16) Confidence 0.52 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0 Pain Relevance 0.33
Capsaicin administration inhibited the stimulated gastrin and histamine secretion and reversed the suppression of somatostatin secretion mediated by vagal stimulation.
Negative_regulation (inhibited) of Localization (secretion) of gastrin
17) Confidence 0.52 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19296048 Disease Relevance 0 Pain Relevance 0
In is concluded that GLP-1 (7-36) amide is the biologically effective peptide that stimulates gastric somatostatin and inhibits gastrin secretion, probably via non-neural pathways.
Negative_regulation (inhibits) of Localization (secretion) of gastrin in neural associated with somatostatin
18) Confidence 0.52 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1972810 Disease Relevance 0 Pain Relevance 0.38
GLP-1 (7-36) amide-induced inhibition of gastric acid secretion may, at least in part, be due to enhanced somatostatin and/or decreased gastrin release.
Negative_regulation (decreased) of Localization (release) of gastrin associated with somatostatin
19) Confidence 0.52 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1972810 Disease Relevance 0 Pain Relevance 0.36
The decrease in antral plasma gastrin release was significantly lower after acid instillation and the increase was significantly higher after alkali instillation in duodenal ulcer patients compared with those of controls, indicating an abnormal gastrin response to intragastric pH changes in duodenal ulcer patients, which was again not found to be coupled to any significant difference in antral somatostatin release.
Negative_regulation (decrease) of Localization (release) of gastrin in plasma associated with duodenal ulcer and somatostatin
20) Confidence 0.47 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7924733 Disease Relevance 0.43 Pain Relevance 0.25

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