INT72531

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2000
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.18
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 4 99.84 Very High Very High Very High
Analgesic 16 99.58 Very High Very High Very High
Pain threshold 2 97.08 Very High Very High Very High
Endogenous opioid 2 96.60 Very High Very High Very High
Enkephalin 5 94.80 High High
Locus ceruleus 5 78.64 Quite High
Central nervous system 2 75.00 Quite High
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 2 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This implies that the analgesic effect of IL-2 might be mediated by interaction between IL-2 and opioid receptors in CNS.
IL-2 Spec (might) Binding (interaction) of associated with analgesic and opioid receptor
1) Confidence 0.48 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389181 Disease Relevance 0.08 Pain Relevance 0.81
The monoclonal antibody against IL-2R (Tac) could not block the analgesic effect of IL-2, and IL-2 mutant that could not bind to beta subunit of IL-2 receptor still had capability of increasing the pain threshold of rats.
IL-2 Neg (not) Binding (bind) of associated with pain threshold and analgesic
2) Confidence 0.36 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389181 Disease Relevance 0.10 Pain Relevance 0.64
This effect is related to opioid receptors and mediated mainly by IL-2 directly binding to opioid receptors.
IL-2 Binding (binding) of associated with opioid receptor
3) Confidence 0.36 Published 2000 Journal Neuroreport Section Abstract Doc Link 10841362 Disease Relevance 0 Pain Relevance 0.87

General Comments

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