INT72532

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.91
Pain Relevance 6.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
proximal 2
alveolar macrophages 2
brain 2
bowel 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 220 100.00 Very High Very High Very High
cytokine 158 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
Action potential 6 100.00 Very High Very High Very High
Etanercept 2 100.00 Very High Very High Very High
Adalimumab 2 100.00 Very High Very High Very High
Infliximab 1 100.00 Very High Very High Very High
anakinra 1 100.00 Very High Very High Very High
intrathecal 3 99.48 Very High Very High Very High
Osteoarthritis 30 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 230 100.00 Very High Very High Very High
Injury 67 99.20 Very High Very High Very High
Osteoarthritis 42 99.12 Very High Very High Very High
Pain 37 98.36 Very High Very High Very High
Disease 118 98.12 Very High Very High Very High
Rheumatoid Arthritis 2 97.36 Very High Very High Very High
Body Weight 4 96.80 Very High Very High Very High
Nervous System Injury 11 96.72 Very High Very High Very High
Inflammatory Bowel Disease 2 96.36 Very High Very High Very High
Hyperalgesia 94 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of intrahippocampal microinjection of enkephalin on cellular immune function and hippocampal IL-1 alpha gene expression was studied in rats.
Regulation (effect) of Gene_expression (expression) of IL-1 alpha gene associated with enkephalin
1) Confidence 0.54 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.51
[Effect of intrahippocampal microinjection of enkephalin on cellular immune function and brain IL-1 alpha gene expression in rat].
Regulation ([Effect) of Gene_expression (expression) of IL-1 alpha gene in brain associated with enkephalin
2) Confidence 0.39 Published 1996 Journal Sheng Li Xue Bao Section Title Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.77
Down-regulation of IL-1RI expression by repeated intrathecal antisense ODN (50 microg/10 microl) significantly increased the mean PWL up to 5.75+/-0.15 s in 180-300 min post-carrageenan injection.
Regulation (regulation) of Gene_expression (expression) of IL-1RI associated with intrathecal
3) Confidence 0.27 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19022353 Disease Relevance 0.58 Pain Relevance 1.37
Increased production of TNF-alpha and IL-1 in alveolar macrophages was observed in response to SEA and SEB.
Regulation (alveolar macrophages) of Gene_expression (production) of IL-1 in alveolar macrophages
4) Confidence 0.14 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19375418 Disease Relevance 0 Pain Relevance 0.41
In comparison with control group rats, the levels of IL-1?
Regulation (control) of Gene_expression (levels) of IL-1
5) Confidence 0.09 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900062 Disease Relevance 0.21 Pain Relevance 0.05
evoked no statistically significant change in the frequency of action potentials: in the case of IL-1?
Neg (no) Regulation (change) of Gene_expression (case) of IL-1 associated with action potential
6) Confidence 0.08 Published 2010 Journal Respiratory Physiology & Neurobiology Section Body Doc Link PMC2958315 Disease Relevance 0 Pain Relevance 0.23
Monoclonal anti-TNF therapies such as infliximab (Remicade®) and adalimumab (Humira®), the TNF receptor fusion protein etanercept (Enbrel®), and the soluble IL-1 receptor anakinra (Kineret®) have proven to be effective for the treatment of a number of inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease [11-16].
Regulation (effective) of Gene_expression (therapies) of IL-1 in bowel associated with anakinra, inflammation, infliximab, rheumatoid arthritis, adalimumab, disease and etanercept
7) Confidence 0.06 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 1.41 Pain Relevance 1.68
in rats is about 40 min [49], it is unlikely that a down-regulation of the existing IL-1?
Regulation (regulation) of Gene_expression (existing) of IL-1
8) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.87 Pain Relevance 0.66
Therefore, the total numbers of patients in the ITT samples differ between the analysis of the IL-1?
Regulation (differ) of Gene_expression (analysis) of IL-1
9) Confidence 0.05 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.07 Pain Relevance 0.04
In the present study macrophages were numerous in the proximal perineurium showing simultaneous high expression of IL-1?
Regulation (numerous) of Gene_expression (expression) of IL-1 in proximal
10) Confidence 0.03 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1310517 Disease Relevance 0.47 Pain Relevance 0.33
The effects of berberine chloride on the expression of IL-1?
Regulation (effects) of Gene_expression (expression) of IL-1
11) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.09 Pain Relevance 0.09
So in this study, we chosed the dose 50 mg/kg to study berberine's effect on the expression of IL-1?
Regulation (effect) of Gene_expression (expression) of IL-1
12) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.17 Pain Relevance 0.08
Real time PCR was conducted to determine the relative change in mRNA expression of pro-inflammatory cytokines IL-1?
Spec (determine) Regulation (change) of Spec (determine) Gene_expression (expression) of IL-1 associated with inflammation and cytokine
13) Confidence 0.03 Published 2010 Journal Radiat Oncol Section Abstract Doc Link PMC2845595 Disease Relevance 0.94 Pain Relevance 0.41
Immunohistochemical evaluation of the effects of berberine chloride on the expression of IL-1?
Regulation (evaluation) of Gene_expression (expression) of IL-1
14) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.10 Pain Relevance 0.09

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