INT72535

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.98
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maob) oxidoreductase activity (Maob)
Anatomy Link Frequency
platelet 1
Maob (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 12 100.00 Very High Very High Very High
Migraine 10 91.08 High High
fluoxetine 4 87.52 High High
Neurotransmitter 1 81.52 Quite High
medulla 1 74.72 Quite High
palliative 1 63.92 Quite High
Disease Link Frequency Relevance Heat
Scrapie 4 99.44 Very High Very High Very High
Migraine With Aura 3 93.76 High High
Migraine Without Aura 4 93.36 High High
Disease 4 90.40 High High
Headache 7 89.24 High High
Infection 1 88.88 High High
Aging 1 71.88 Quite High
Creutzfeldt Jakob Disease 1 68.80 Quite High
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The in vivo effects of the various drugs were directly comparable to their in vitro affinities for binding to monoamine oxidase B in the correlation plot of percent control in vivo binding of [18F]FHMP and binding affinity, -logIC50 (R2 = 0.989).
oxidase B Binding (binding) of associated with monoamine
1) Confidence 0.42 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9389388 Disease Relevance 0 Pain Relevance 0.58
Regarding these results, MAO-B could be a potential therapeutic target then we have performed a pre-clinical treatment with irreversible (Selegiline or L-deprenyl) or and reversible (MS-9510) MAO-B inhibitors used alone or in association with an anti-scrapie drug such as MS-8209, an amphotericin B derivative.
MAO-B Binding (association) of associated with scrapie
2) Confidence 0.33 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18442871 Disease Relevance 0.88 Pain Relevance 0.17
In addition, we have reevaluated the reported association between MAO-B intron 13 polymorphism and platelet MAO-B activity.
MAO-B Binding (association) of in platelet
3) Confidence 0.09 Published 2005 Journal J. Neurol. Sci. Section Abstract Doc Link 15694196 Disease Relevance 1.09 Pain Relevance 0.97

General Comments

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