INT72538

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.49
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sorbs1) transport (Sorbs1) plasma membrane (Sorbs1)
cytoskeleton (Sorbs1) nucleus (Sorbs1) cytoplasm (Sorbs1)
Anatomy Link Frequency
bone marrow 2
neuronal 1
Sorbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 69 100.00 Very High Very High Very High
Action potential 20 100.00 Very High Very High Very High
Neuropeptide 11 99.74 Very High Very High Very High
antinociception 5 99.02 Very High Very High Very High
Nerve growth factor 101 98.86 Very High Very High Very High
Hyperalgesia 3 98.36 Very High Very High Very High
Inflammation 76 96.60 Very High Very High Very High
c fibre 10 94.88 High High
narcan 8 94.72 High High
Calcitonin gene-related peptide 96 94.68 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 7 98.36 Very High Very High Very High
INFLAMMATION 85 96.60 Very High Very High Very High
Obesity 252 96.16 Very High Very High Very High
Nociception 20 95.52 Very High Very High Very High
Insulin Resistance 68 94.72 High High
Nerve Compression Syndromes 31 90.44 High High
Ganglion Cysts 109 84.56 Quite High
Pain 16 83.44 Quite High
Atherosclerosis 8 75.96 Quite High
Epilepsy 1 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given i.c.v., both CPZ and RR caused discrete antinociception in the FM (both phases), while producing graded inhibition of CAP.
Negative_regulation (inhibition) of CAP associated with antinociception and qutenza
1) Confidence 0.59 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9389599 Disease Relevance 0.40 Pain Relevance 1.62
Furthermore, these effects of CAP could be reversed by capsazepine, the antagonist of transient receptor potential vanilloid type 1 channel.
Negative_regulation (reversed) of CAP
2) Confidence 0.48 Published 2010 Journal Urology Section Body Doc Link 19592070 Disease Relevance 0.06 Pain Relevance 0
This is further supported by the observation that mice with bone marrow-restricted disruption of cbl-associated protein (CAP), a downstream component of insulin action in control of glucose transport, are protected from obesity-associated inflammation and insulin resistance [18].
Negative_regulation (disruption) of CAP in bone marrow associated with inflammation, obesity and insulin resistance
3) Confidence 0.15 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.35 Pain Relevance 0.26
This is further supported by the observation that mice with bone marrow-restricted disruption of cbl-associated protein (CAP), a downstream component of insulin action in control of glucose transport, are protected from obesity-associated inflammation and insulin resistance [18].
Negative_regulation (disruption) of cbl-associated protein in bone marrow associated with inflammation, obesity and insulin resistance
4) Confidence 0.15 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.35 Pain Relevance 0.26
CAP was decreased, showing a time-dependent effect that was stabilized after 20?
Negative_regulation (decreased) of CAP associated with action potential
5) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2952823 Disease Relevance 0.34 Pain Relevance 0.90
This difference in the ability of GDNF and NGF to enhance individual neuronal neuropeptide content and CAP responsiveness could partially explain why NGF induces hyperalgesia [10,12,19,61] while GDNF does not [15,28,29].
Negative_regulation (responsiveness) of CAP in neuronal associated with hyperalgesia, qutenza, nerve growth factor and neuropeptide
6) Confidence 0.02 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.50 Pain Relevance 1.14
Concentration-dependent decreases in CAP amplitude were detected within 30 sec after TTX (0.1–1 ?
Negative_regulation (decreases) of CAP
7) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.49 Pain Relevance 0.43

General Comments

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