INT7256

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Context Info
Confidence 0.37
First Reported 1988
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
brain 2
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 99.64 Very High Very High Very High
Dopamine 11 99.52 Very High Very High Very High
gABA 14 99.36 Very High Very High Very High
Clonidine 1 99.32 Very High Very High Very High
Nicotine 6 98.72 Very High Very High Very High
withdrawal 5 98.56 Very High Very High Very High
tetrodotoxin 3 97.56 Very High Very High Very High
antagonist 3 97.00 Very High Very High Very High
tolerance 1 92.88 High High
noradrenaline 3 91.40 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, mecamylamine alone inhibited the basal release of DOPA but not of DA.
Negative_regulation (inhibited) of Localization (release) of DOPA associated with dopamine
1) Confidence 0.37 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1361443 Disease Relevance 0 Pain Relevance 0.63
Electrical stimulation at 2 Hz evoked DOPA and DA over similar time courses. alpha-Methyl-p-tyrosine (0.2 mM) markedly reduced release of DOPA but not of DA.
Negative_regulation (reduced) of Localization (release) of DOPA
2) Confidence 0.19 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2897424 Disease Relevance 0 Pain Relevance 0.14
The basal release of DOPA was markedly decreased by alpha-methyl-p-tyrosine (200 mg/kg, i.p.), substantially tetrodotoxin (1 microM) sensitive, and Ca2+ (removal plus 12.5 mM Mg2+ addition) dependent.
Negative_regulation (decreased) of Localization (release) of DOPA associated with tetrodotoxin
3) Confidence 0.12 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1345766 Disease Relevance 0 Pain Relevance 0.14
The inhibitory effect of clonidine (alpha2-agonist; 1 mg/kg) on the accumulation of DOPA (15-41%) and 5-HTP (22-41%) was markedly decreased or abolished after chronic WIN and precipitated withdrawal, mainly in noradrenergic and serotonergic brain regions, which indicated desensitization of alpha2-autoreceptors and alpha2-heteroreceptors regulating the synthesis of noradrenaline and 5-HT.
Negative_regulation (abolished) of Localization (accumulation) of DOPA in brain associated with noradrenaline, agonist, withdrawal and clonidine
4) Confidence 0.07 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18709357 Disease Relevance 0 Pain Relevance 0.98
We tried to clarify whether basal DOPA release is inhibited by muscimol, a GABA(A) agonist, and facilitated by bicuculline, a GABA(A) antagonist, during microdialysis of the NTS in anesthetized rats.
Spec (whether) Negative_regulation (inhibited) of Spec (whether) Localization (release) of DOPA associated with gaba, antagonist and agonist
5) Confidence 0.03 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081972 Disease Relevance 0 Pain Relevance 0.47
Muscimol 10-100 microM perfused via probes gradually inhibited concentration-dependently DOPA release.
Negative_regulation (inhibited) of Localization (release) of DOPA
6) Confidence 0.02 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081972 Disease Relevance 0 Pain Relevance 0.46

General Comments

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