INT72565

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Context Info
Confidence 0.80
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 23.59
Pain Relevance 13.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
blood 4
shoulder 3
joint 3
Discal cells 2
PBMC 2
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 192 100.00 Very High Very High Very High
Inflammation 481 99.66 Very High Very High Very High
Pain 65 99.54 Very High Very High Very High
Cannabinoid 118 99.44 Very High Very High Very High
anesthesia 11 98.52 Very High Very High Very High
cytokine 341 98.42 Very High Very High Very High
shoulder pain 43 98.08 Very High Very High Very High
isoflurane 2 97.56 Very High Very High Very High
diclofenac 6 95.80 Very High Very High Very High
cINOD 25 92.60 High High
Disease Link Frequency Relevance Heat
Cancer 43 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Sprains And Strains 436 99.98 Very High Very High Very High
Sicca Syndrome 7 99.76 Very High Very High Very High
INFLAMMATION 512 99.66 Very High Very High Very High
Pain 43 99.54 Very High Very High Very High
Injury 8 99.32 Very High Very High Very High
Sepsis 47 98.88 Very High Very High Very High
Inflammatory Bowel Disease 330 98.16 Very High Very High Very High
Death 27 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mofezolac suppressed the mRNA expression for IL-1 beta in PBMC stimulated with exogenous IL-1 beta, indicating the secreted IL-1ra in the presence of mofezolac to be biologically active.
Localization (secreted) of IL-1ra in PBMC
1) Confidence 0.80 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.24 Pain Relevance 0.76
These two drugs also stimulated the secretion of IL-1ra by PBMC in the absence of bacterial lipopolysaccharide (LPS), however, the stimulatory effect of sodium diclofenac diminished in the presence of LPS.
Localization (secretion) of IL-1ra in PBMC associated with diclofenac
2) Confidence 0.80 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.23 Pain Relevance 0.74
The objective of this study was the detection of IL-1beta and IL-1Ra secreted by herniated lumbar discal cells after discectomy.
Localization (secreted) of IL-1Ra in discal cells
3) Confidence 0.75 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.09 Pain Relevance 0.22
Spontaneous secretion of IL-1Ra was found.
Localization (secretion) of IL-1Ra
4) Confidence 0.75 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.20
Discal cells were isolated, cultures and culture supernatants immunochemically analysed for IL-1beta and IL-1Ra secretion.
Spec (analysed) Localization (secretion) of IL-1Ra in Discal cells
5) Confidence 0.75 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.09 Pain Relevance 0.20
Spontaneous secretion of interleukin 1 receptor antagonist (IL-1ra) by cells isolated from herniated lumbar discal tissue after discectomy.
Localization (secretion) of IL-1ra associated with antagonist
6) Confidence 0.75 Published 1998 Journal Cytokine Section Title Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.22
Spontaneous secretion of interleukin 1 receptor antagonist (IL-1ra) by cells isolated from herniated lumbar discal tissue after discectomy.
Localization (secretion) of interleukin 1 receptor associated with antagonist
7) Confidence 0.75 Published 1998 Journal Cytokine Section Title Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.22
, inducing anti-inflammatory activity by the release of IL-1ra and IL-10.
Localization (release) of IL-1ra associated with inflammation
8) Confidence 0.73 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.34 Pain Relevance 0.16
Experiment 1: ISZ localization of matrix degrading activity in normal and degenerate IVDs – the effects of IL-1, IL-1Ra and inhibitors of matrix degrading enzymes
Localization (localization) of IL-1Ra
9) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.18 Pain Relevance 0
We have previously shown that untransfected cells secrete picogram quantities of IL-1Ra, which could account for some of the changes [15].
Localization (secrete) of IL-1Ra
10) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.08 Pain Relevance 0.03
Spontaneous secretion of interleukin 1 receptor antagonist (IL-1ra) by cells isolated from herniated lumbar discal tissue after discectomy.
Localization (secretion) of antagonist associated with antagonist
11) Confidence 0.57 Published 1998 Journal Cytokine Section Title Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.22
To verify that S. gordonii GP1300 released IL-1ra into the culture medium, strains GP1300 and GP1221 were grown in TSB to early stationary phase.
Localization (released) of IL-1ra associated with sprains and strains
12) Confidence 0.57 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.36 Pain Relevance 0
In addition, to verify that S. gordonii was also capable of releasing IL-1ra in vivo in the gastrointestinal tract (GI), mice were inoculated via the intragastric route with the GP1294 strain.
Localization (releasing) of IL-1ra associated with sprains and strains
13) Confidence 0.57 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.29 Pain Relevance 0.06
Therefore, this approach appears suitable for achieving the in vivo release of RVFP/IL-1ra at mucosal surfaces.
Localization (release) of IL-1ra
14) Confidence 0.57 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0 Pain Relevance 0.04
An S. gordonii strain secreting human IL-1ra into the culture medium was constructed using the previously described host-vector system [31].
Localization (secreting) of IL-1ra associated with sprains and strains
15) Confidence 0.57 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.59 Pain Relevance 0.07
S. gordonii GP1300 and GP1294 secrete human IL-1ra into the culture medium.
Localization (secrete) of IL-1ra
16) Confidence 0.57 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.66 Pain Relevance 0.11
Net OD450 readings are reported, as qualitative indication of IL-1ra presence in the tissues.
Localization (presence) of IL-1ra
17) Confidence 0.53 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.19 Pain Relevance 0
IL-1ra secreted by S. gordonii is biologically active
Localization (secreted) of IL-1ra
18) Confidence 0.50 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.15 Pain Relevance 0
In addition, S. gordonii was also shown to release recombinant RVFP/IL-1ra in vivo in the GI tract of mice for at least 11 days after bacterial administration.
Localization (release) of IL-1ra
19) Confidence 0.50 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0 Pain Relevance 0.03
These results suggest that recombinant S. gordonii, that is able to release bioactive IL-1ra in the GI tract, can improve the symptoms of ulcerative colitis.
Localization (release) of IL-1ra associated with inflammatory bowel disease
20) Confidence 0.50 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 1.12 Pain Relevance 0.15

General Comments

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