INT7257

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 1999
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 0
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 14 100.00 Very High Very High Very High
tetrodotoxin 7 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Nicotine 22 99.74 Very High Very High Very High
Dopamine 31 99.42 Very High Very High Very High
antagonist 2 98.92 Very High Very High Very High
Neurotransmitter 2 89.36 High High
Central nervous system 2 77.52 Quite High
GABAergic 2 75.00 Quite High
anesthesia 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The (+/-)-nicotine (200 microM)-induced DOPA release was mecamylamine (500 microM)-sensitive, tetrodotoxin (100 nM)-sensitive and Ca2+ (removal plus 12.5 mM Mg2+ addition)-dependent.
Positive_regulation (induced) of Localization (release) of DOPA associated with tetrodotoxin and nicotine
1) Confidence 0.59 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1361443 Disease Relevance 0 Pain Relevance 0.64
The turnover rate of DOPA was about 300 times higher compared to DA. (+/-)-Nicotine (10 microM)-induced DOPA release was mecamylamine (20 microM)-sensitive, Ca2(+)-dependent and tetrodotoxin (0.3 microM)-insensitive.
Positive_regulation (induced) of Localization (release) of DOPA associated with tetrodotoxin, dopamine and nicotine
2) Confidence 0.59 Published 1990 Journal Brain Res. Section Abstract Doc Link 2119849 Disease Relevance 0 Pain Relevance 0.65
The (+/-)-nicotine (200 microM)-induced DOPA release was mecamylamine (500 microM)-sensitive, tetrodotoxin (100 nM)-sensitive and Ca2+ (removal plus 12.5 mM Mg2+ addition)-dependent.
Positive_regulation (-induced) of Localization (release) of DOPA associated with tetrodotoxin and nicotine
3) Confidence 0.43 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1361443 Disease Relevance 0 Pain Relevance 0.64
The (+)-isomer induced no DOPA release.
Neg (no) Positive_regulation (induced) of Localization (release) of DOPA
4) Confidence 0.40 Published 1990 Journal Brain Res. Section Abstract Doc Link 2119849 Disease Relevance 0 Pain Relevance 0.66
The impulse-evoked release of DOPA and DA was completely tetrodotoxin (0.3 microM) sensitive and Ca2+ dependent and the 15 mM K+-evoked release was also Ca2+ dependent.
Positive_regulation (dependent) of Localization (release) of DOPA associated with tetrodotoxin
5) Confidence 0.21 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2897424 Disease Relevance 0 Pain Relevance 0.14
On L-[3,5-3H]tyrosine (1 microM) superfusion, high K+ (15 and 60 mM) released DOPA and DA together with concentration-dependent decreases in tyrosine 3-monooxygenase (EC 1.14.16.2) activity as indicated by [3H]H2O formation, followed by concentration-dependent increases after DOPA and DA release ended.
Positive_regulation (increases) of Localization (release) of DOPA
6) Confidence 0.21 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2897424 Disease Relevance 0 Pain Relevance 0.12
The ratio of the basal release of DOPA:DA was 1:2. 3-Hydroxybenzylhydrazine (NSD-1015; 100 mg/kg, i.p.), an AADC inhibitor, markedly increased the basal release of DOPA but produced no effect on DA.
Positive_regulation (increased) of Localization (release) of DOPA
7) Confidence 0.13 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1345766 Disease Relevance 0 Pain Relevance 0.13
We tried to clarify whether basal DOPA release is inhibited by muscimol, a GABA(A) agonist, and facilitated by bicuculline, a GABA(A) antagonist, during microdialysis of the NTS in anesthetized rats.
Spec (whether) Positive_regulation (facilitated) of Spec (whether) Localization (release) of DOPA associated with gaba, antagonist and agonist
8) Confidence 0.04 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081972 Disease Relevance 0 Pain Relevance 0.47
Bicuculline (30 microM) elicited peak 30% facilitation of DOPA release 2 h after perfusion.
Positive_regulation (elicited) of Localization (release) of DOPA
9) Confidence 0.03 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081972 Disease Relevance 0 Pain Relevance 0.45

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