INT72579

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Context Info
Confidence 0.80
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 56
Total Number 57
Disease Relevance 14.84
Pain Relevance 10.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
neurons 8
annulus 5
brain 4
neural 2
skin 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 384 100.00 Very High Very High Very High
bDMF 41 100.00 Very High Very High Very High
Somatostatin 14 100.00 Very High Very High Very High
antidepressant 103 99.80 Very High Very High Very High
spinal dorsal horn 3 99.68 Very High Very High Very High
tetrodotoxin 17 99.52 Very High Very High Very High
cva 150 99.36 Very High Very High Very High
Pain 163 99.16 Very High Very High Very High
nociceptor 27 99.12 Very High Very High Very High
central sensitization 18 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 9 99.80 Very High Very High Very High
Nervous System Injury 21 99.68 Very High Very High Very High
Cv General 4 Under Development 127 99.36 Very High Very High Very High
Dissociative Disorders 11 99.22 Very High Very High Very High
Pain 262 97.56 Very High Very High Very High
Nociception 97 97.36 Very High Very High Very High
Disease 94 97.32 Very High Very High Very High
Injury 169 96.84 Very High Very High Very High
Hypersensitivity 54 96.52 Very High Very High Very High
Death 52 96.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proportion of cells positive for BDNF localization was determined for the outer annulus, the inner annulus and the nucleus.
Localization (localization) of BDNF in nucleus
1) Confidence 0.80 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
Sand rat lumbar IVDs sectioned en face showed a similar pattern of localization of BDNF.
Localization (localization) of BDNF in face
2) Confidence 0.80 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
Immunohistochemical specimens used in the localization of BDNF and of the BDNF receptor are described in Table 1.
Localization (localization) of BDNF receptor
3) Confidence 0.80 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
Spines from seven animals were used in the present study of the immunolocalization of BDNF.
Localization (immunolocalization) of BDNF in Spines
4) Confidence 0.80 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.18 Pain Relevance 0
Facilitated neurotrophin release in sensitized human skin.
Localization (release) of neurotrophin in skin
5) Confidence 0.78 Published 2009 Journal Eur J Pain Section Title Doc Link 18571954 Disease Relevance 0.34 Pain Relevance 0.56
These data demonstrate enhanced level of neurotrophin release in inflamed human skin in vivo which might well contribute to peripheral sensitization.
Localization (release) of neurotrophin in skin associated with peripheral sensitization
6) Confidence 0.78 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18571954 Disease Relevance 0.25 Pain Relevance 0.47
Localization patterns were similar for the BDNF receptor to that seen for BDNF.
Localization (Localization) of BDNF receptor
7) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
BDNF-receptor immunolocalization
Localization (immunolocalization) of BDNF-receptor
8) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
BDNF-receptor immunolocalization
Localization (immunolocalization) of BDNF-receptor
9) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Localization (morphogens) of neurotrophin
10) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Localization (several) of neurotrophin
11) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
exon3 failed to localize to axons but accumulated in somato-dendritic areas in cultured cerebellar and cortical neurons, suggesting a possible disturbance of local CAPS2-mediated neurotrophin release [12].
Localization (release) of neurotrophin in neurons
12) Confidence 0.73 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0.25 Pain Relevance 0.05
We characterized the expression patterns and neurotrophin release properties of these isoforms.


Localization (release) of neurotrophin
13) Confidence 0.73 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0.23 Pain Relevance 0
Neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4, are a family of secreted growth factors that promote the survival, differentiation and maintenance of specific neuronal populations and regulate activity-dependent synaptic plasticity (reviewed in Bibel and Barde, 2000).
Localization (secreted) of Neurotrophin in brain associated with nerve growth factor
14) Confidence 0.73 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.57 Pain Relevance 0.35
The percentage (mean ± standard error of the mean) of cells positive for BDNF localization was significantly greater in the outer annulus (32.3 ± 2.7%, n = 22) compared with either the inner annulus (8.1 ± 1.5%, n = 6) or the nucleus (10.4 ± 2.8%, n = 3) (P < 0.0001).
Localization (localization) of BDNF in annulus
15) Confidence 0.71 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575628 Disease Relevance 0.26 Pain Relevance 0.13
We studied immunohistochemical localization of BDNF and its receptor in the human annulus, quantified the percentage of outer annulus and inner annulus cells and nucleus cells positive for BDNF immunolocalization, and studied the gene expression of BDNF and its receptor using microarray analysis.


Localization (localization) of BDNF in annulus
16) Confidence 0.71 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575628 Disease Relevance 0.32 Pain Relevance 0.16
Immunolocalization of BDNF was greatest in the outer annulus (Figure 1a,b).
Localization (Immunolocalization) of BDNF in annulus
17) Confidence 0.70 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
Immunohistochemical specimens used in the localization of BDNF and of the BDNF receptor are described in Table 1.
Localization (localization) of BDNF
18) Confidence 0.70 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
Sections were processed for immunohistochemical localization of BDNF as described below.


Localization (localization) of BDNF
19) Confidence 0.70 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.06 Pain Relevance 0
Ca2+-dependent activator protein 2 (CAPS2/CADPS2) is a secretory vesicle-associated protein involved in the release of neurotrophin.
Localization (release) of neurotrophin in vesicle
20) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1853102 Disease Relevance 0.09 Pain Relevance 0

General Comments

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