INT72591

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Context Info
Confidence 0.64
First Reported 1997
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.65
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn4a) transmembrane transport (Scn4a)
Anatomy Link Frequency
skeletal muscle 2
Scn4a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 15 97.72 Very High Very High Very High
sodium channel 3 94.00 High High
Pain 3 80.40 Quite High
Disease Link Frequency Relevance Heat
Disease 1 99.76 Very High Very High Very High
Paralysis 1 98.96 Very High Very High Very High
Myotonia 4 98.04 Very High Very High Very High
Pain 1 80.40 Quite High
Syndrome 1 60.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most disease-associated SCN4A alleles occur in portions of the gene that encode the third and fourth repeat domains with the conspicuous absence of mutations in domain 1.
Gene_expression (occur) of SCN4A associated with disease
1) Confidence 0.64 Published 1997 Journal Ann. Neurol. Section Abstract Doc Link 9392583 Disease Relevance 0.65 Pain Relevance 0.24
We found that mH2 is not expressed in cardiac cells of neonatal mice, but appears to be upregulated during the development.
Neg (not) Gene_expression (expressed) of mH2
2) Confidence 0.39 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11834499 Disease Relevance 0 Pain Relevance 0.28
Sequence comparisons indicated that mH1 is highly homologous to rat SCN5A, whereas mH2 is highly homologous to SCN4A, expressed in rat skeletal muscle.
Gene_expression (expressed) of mH2 in skeletal muscle
3) Confidence 0.31 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11834499 Disease Relevance 0 Pain Relevance 0.26
Sequence comparisons indicated that mH1 is highly homologous to rat SCN5A, whereas mH2 is highly homologous to SCN4A, expressed in rat skeletal muscle.
Gene_expression (expressed) of SCN4A in skeletal muscle
4) Confidence 0.31 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11834499 Disease Relevance 0 Pain Relevance 0.26

General Comments

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