INT72598

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.16
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2) plasma membrane (ITGA2)
Anatomy Link Frequency
platelet 2
ITGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 2 99.12 Very High Very High Very High
interstitial cystitis 8 93.28 High High
endometriosis 2 50.00 Quite Low
Dismenorea 2 50.00 Quite Low
aspirin 2 47.28 Quite Low
cva 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 2 99.48 Very High Very High Very High
Acute Coronary Syndrome 6 99.46 Very High Very High Very High
Interstitial Cystitis 8 93.28 High High
Dysmenorrhea 2 80.00 Quite High
Endometriosis (extended) 2 79.40 Quite High
Adhesions 1 50.00 Quite Low
Death 1 42.16 Quite Low
Myocardial Infarction 1 41.44 Quite Low
Infarction 1 25.00 Low Low
Cardiovascular Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The approval of eptifibatide for non-ST-segment elevation ACS was based on the positive results of the Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) trial.
Positive_regulation (results) of Platelet Glycoprotein in Platelet associated with acute coronary syndrome, angina and cv general 3 under development
1) Confidence 0.47 Published 2000 Journal Clin Cardiol Section Abstract Doc Link 11019716 Disease Relevance 0.54 Pain Relevance 0.10
RESULTS: The expression of each VLA molecule and E-cadherin except VLA-4, VLA-5, and VLA-6 was significantly increased throughout the menstrual cycle in endometria in both the endometriosis and adenomyosis groups.
Positive_regulation (increased) of VLA-4
2) Confidence 0.08 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.16 Pain Relevance 0
Activation of the platelet glycoprotein (GP IIb/IIIa) receptor on the platelet surface is the final pathway of platelet aggregation, regardless of the initiating stimulus.
Positive_regulation (Activation) of platelet glycoprotein in platelet
3) Confidence 0.03 Published 2000 Journal Circulation Section Abstract Doc Link 10673265 Disease Relevance 0 Pain Relevance 0
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Positive_regulation (confirmed) of alpha2-integrin associated with interstitial cystitis
4) Confidence 0.01 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.46 Pain Relevance 0.46

General Comments

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