INT72599

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Context Info
Confidence 0.09
First Reported 1997
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.30
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2) plasma membrane (ITGA2)
ITGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 16 95.82 Very High Very High Very High
endometriosis 2 50.00 Quite Low
Dismenorea 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 16 95.82 Very High Very High Very High
Dysmenorrhea 2 73.44 Quite High
Endometriosis (extended) 2 72.84 Quite High
Adhesions 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the expression of VLA-4 in the adenomyosis group was significantly reduced in the secretory phase.
Negative_regulation (reduced) of Gene_expression (expression) of VLA-4
1) Confidence 0.09 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.15 Pain Relevance 0
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Negative_regulation (decreased) of Gene_expression (expression) of alpha2-integrin associated with interstitial cystitis
2) Confidence 0.02 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.58 Pain Relevance 0.58
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Negative_regulation (decreased) of Gene_expression (expression) of alpha2-integrin associated with interstitial cystitis
3) Confidence 0.02 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.58 Pain Relevance 0.58

General Comments

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