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Context Info
Confidence 0.25
First Reported 1997
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.95
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
macrophage 2
chondrocytes 1
osteoclast 1
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 99.56 Very High Very High Very High
Inflammation 8 98.88 Very High Very High Very High
cytokine 15 97.54 Very High Very High Very High
Snapping jaw 8 89.36 High High
Calcium channel 1 83.08 Quite High
Morphine 3 75.00 Quite High
opiate 2 72.92 Quite High
Opioid 1 70.32 Quite High
analgesia 2 54.08 Quite High
Spinal cord 1 52.40 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 3 99.56 Very High Very High Very High
Cancer 84 96.54 Very High Very High Very High
Hypercalcemia 25 92.76 High High
Arthropathy 4 90.72 High High
Metastasis 45 90.28 High High
Temporomandibular Joint Syndrome 8 89.36 High High
Osteoporosis 35 83.24 Quite High
Histiocytic Sarcoma 1 75.00 Quite High
Low Back Pain 2 74.92 Quite High
Spontaneous Fractures 2 72.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In many previous studies on M-CSF, RANKL, and OPG expression in chondrocytes, the culture periods were brief (24?
Regulation (studies) of M-CSF in chondrocytes
1) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.09
Additionally, the data indicate that MCSF deregulation may be involved as an initiating factor for this disorder.
Regulation (deregulation) of MCSF
2) Confidence 0.15 Published 1997 Journal Am. J. Hematol. Section Abstract Doc Link 9395179 Disease Relevance 0.07 Pain Relevance 0.38
METHODS AND RESULTS: Plasma macrophage colony stimulating factor (MCSF), IL-1b, IL-6, and CRP were measured in 60 stable patients after 48-hour Holter monitoring and in 24 matched controls.
Regulation (measured) of MCSF in macrophage
3) Confidence 0.15 Published 1999 Journal Circulation Section Body Doc Link 10458713 Disease Relevance 0.10 Pain Relevance 0
Prognostic value of C-reactive protein, fibrinogen, interleukin-6, and macrophage colony stimulating factor in severe unstable angina.
Regulation (value) of colony stimulating factor in macrophage associated with angina
4) Confidence 0.14 Published 2002 Journal Clin Cardiol Section Title Doc Link 12430780 Disease Relevance 0.10 Pain Relevance 0.15
Infusions of infliximab in AS patients led to a significant decrease in the values of the BASDAI as well as the serum MMP-3, but no change in the serum M-CSF values.
Neg (no) Regulation (change) of M-CSF
5) Confidence 0.12 Published 2004 Journal Arthritis Rheum. Section Body Doc Link 15478146 Disease Relevance 0.07 Pain Relevance 0
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Regulation (responsible) of colony stimulating factor-1 in osteoclast associated with cancer and cytokine
6) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.42 Pain Relevance 0.13
Unlike changes in CSF-5-HT, no significant changes in mean CSF-NA were recorded neither within nor between the two treatment groups.
Neg (no) Regulation (changes) of CSF-NA in CSF
7) Confidence 0.00 Published 2005 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Body Doc Link 15645384 Disease Relevance 0 Pain Relevance 0

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