INT72639

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2004
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 8.57
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ntsr1) plasma membrane (Ntsr1) signal transducer activity (Ntsr1)
Anatomy Link Frequency
medulla 1
pancreas 1
Ntsr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 1 99.68 Very High Very High Very High
Chronic pancreatitis 54 98.68 Very High Very High Very High
medulla 1 97.68 Very High Very High Very High
Analgesic 5 94.68 High High
Intracerebroventricular 1 92.56 High High
agonist 3 90.52 High High
Eae 1 89.28 High High
analgesia 2 83.80 Quite High
Nucleus accumbens 1 83.16 Quite High
Neuropeptide 1 80.32 Quite High
Disease Link Frequency Relevance Heat
Catalepsy 1 99.96 Very High Very High Very High
Pancreatic Cancer 54 99.84 Very High Very High Very High
Cancer 36 99.80 Very High Very High Very High
Nociception 5 99.76 Very High Very High Very High
Urological Neuroanatomy 2 99.68 Very High Very High Very High
Pancreatitis 60 98.68 Very High Very High Very High
Carcinoma 6 96.20 Very High Very High Very High
Targeted Disruption 3 89.08 High High
Hypothermia 2 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene deletion also resulted in the loss of NTR1 expression as determined by reverse transcription-polymerase chain reaction and in situ hybridization.
Gene_expression (expression) of NTR1
1) Confidence 0.78 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752130 Disease Relevance 0.14 Pain Relevance 0.05
Expression and localization of NTR-1 mRNA was investigated by Northern blot analysis and in situ hybridization.
Gene_expression (Expression) of NTR-1 mRNA
2) Confidence 0.70 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.09 Pain Relevance 0.41
By Northern blot analysis, NTR-1 mRNA expression was 4.4-fold (P < 0.01) and 3.0-fold (P < 0.01) higher in pancreatic cancer and CP tissue samples, respectively, compared with normal controls.
Gene_expression (expression) of NTR-1 mRNA associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.70 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.22 Pain Relevance 0.42
In the cancer samples, NTR-1 mRNA was moderately to intensely expressed in the cytoplasm of cancer cells.
Gene_expression (expressed) of NTR-1 mRNA associated with cancer
4) Confidence 0.70 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.50 Pain Relevance 0.49
The enhanced expression of NTR-1 mRNA in pancreatic cancer cells further suggests that neuroendocrine hormones might modulate pancreas cancer cell behavior.
Gene_expression (expression) of NTR-1 mRNA in pancreas associated with pancreatic cancer
5) Confidence 0.70 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.30 Pain Relevance 0.46
Furthermore, consecutive tissue sections were analyzed for NTR-1 mRNA expression and NT binding.
Spec (analyzed) Gene_expression (expression) of NTR-1 mRNA
6) Confidence 0.70 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.19 Pain Relevance 0.42
The expression of Ntsr2 mRNA was greater than that of Ntsr1 in the periaqueductal gray (PAG) and the rostral ventral medulla (RVM).
Gene_expression (expression) of Ntsr1 in medulla associated with medulla, urological neuroanatomy and central grey
7) Confidence 0.65 Published 2004 Journal Brain Res. Section Abstract Doc Link 14725975 Disease Relevance 0.64 Pain Relevance 0.31
When on consecutive tissue sections NTR-1 mRNA expression was compared with the presence of NTR-1, measured by receptor autoradiography, a correlation was found in carcinomas but not in CP samples, in which no receptors were detectable by autoradiography.
Gene_expression (expression) of NTR-1 mRNA associated with carcinoma and chronic pancreatitis
8) Confidence 0.47 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.34 Pain Relevance 0.45
Up to high doses, neurotensin (5.0 and 10.0 micrograms, i.c.v.) and NT1 (10.0 and 20.0 mg/kg, i.p.) did not produce catalepsy.
Neg (not) Gene_expression (produce) of NT1 associated with catalepsy
9) Confidence 0.22 Published 1997 Journal Peptides Section Abstract Doc Link 9396065 Disease Relevance 0.17 Pain Relevance 0.43

General Comments

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