INT72651

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1997
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 114
Total Number 117
Disease Relevance 80.15
Pain Relevance 35.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
T cells 21
Th1 cells 10
macrophages 5
lymphocytes 5
Th2 cells 3
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3351 100.00 Very High Very High Very High
cytokine 3256 100.00 Very High Very High Very High
chemokine 859 100.00 Very High Very High Very High
antidepressant 15 99.80 Very High Very High Very High
Demyelination 9 99.64 Very High Very High Very High
Arthritis 543 99.50 Very High Very High Very High
Central nervous system 74 99.44 Very High Very High Very High
metalloproteinase 79 99.40 Very High Very High Very High
rheumatoid arthritis 968 99.12 Very High Very High Very High
Multiple sclerosis 263 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3706 100.00 Very High Very High Very High
Disease 1736 100.00 Very High Very High Very High
Hypersensitivity 333 100.00 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 476 99.98 Very High Very High Very High
Asthma 3922 99.84 Very High Very High Very High
Papillomavirus Infection 90 99.80 Very High Very High Very High
Infection 809 99.76 Very High Very High Very High
Demyelinating Disease 183 99.64 Very High Very High Very High
Wasting Syndrome 3 99.54 Very High Very High Very High
Experimental Arthritis 40 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate whether DINP affects the phenotypes and function of BMDCs in NC/Nga mice, we examined the production of TH1/TH2 cytokines and chemokines, the expression of cell surface molecules, and antigen-presenting activity of BMDCs after exposure to DINP in vitro.
Spec (examined) Gene_expression (production) of TH1 associated with chemokine and cytokine
1) Confidence 0.75 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.20
In contrast, DINP did not clearly affect Ig levels or the expression of TH1/TH2 cytokines such as IFN-?
Gene_expression (expression) of TH1 associated with cytokine
2) Confidence 0.75 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.73 Pain Relevance 0.12
We investigated whether DINP affects the protein expression of TH1/TH2 cytokines and chemokines in the skin related to Dp.
Gene_expression (expression) of TH1 in skin associated with chemokine and cytokine
3) Confidence 0.75 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.19 Pain Relevance 0.23
To evaluate whether DINP affects the activation of splenocytes in NC/Nga mice, we examined the production of TH1/TH2 cytokines and Dp-stimulated proliferation of splenocytes after exposure to DINP in vitro.
Spec (examined) Gene_expression (production) of TH1 associated with cytokine
4) Confidence 0.75 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.11
MBP, MOG, PLP, MAG), the presence of reactive T cells in blood and, further enriched, in the cerebrospinal fluid (CSF), large numbers of B cells in the CSF secreting antibodies of multiple but unknown specificities, an increase of mononuclear cells (MNC) expressing and secreting both pro- and anti-inflammatory cytokines, including Th1 cytokines interferon-gamma (IFN-gamma) and interleukin (IL)-6, the Th2 related IL-4 and IL-10, and the Th3-driven TGF-beta, elevated numbers of MNC in both blood and CSF expressing a spectrum of metalloproteinases and their inhibitors, as well as many other aberrations.
Gene_expression (expressing) of Th1 in MNC associated with inflammation, metalloproteinase and cytokine
5) Confidence 0.65 Published 2001 Journal Neurol. Sci. Section Abstract Doc Link 11603616 Disease Relevance 0.89 Pain Relevance 0.58
In the present study we found that 24-hr DINP exposure significantly increased the production of the TH2-attracting chemokines TARC/CCL17 (Figure 3A) and MDC/CCL22 (Figure 3B) but not the TH1-polarizing cytokine IL-12p40 (data not shown), and increased the expression of CCR7, CXCR4 (Figure 3C,D), MHC class II, CD80, and CD86 (Figure 3E,F) in BMDCs.
Neg (not) Gene_expression (chemokines) of TH1 in CD86 associated with chemokine and cytokine
6) Confidence 0.65 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.27 Pain Relevance 0.27
Lymphoproliferation and peripheral mononuclear cell cultures production of the Th1 cytokines IL-2 and IFN-gamma, the Th2 cytokine IL-4, and of the pro-inflammatory cytokine TNF-alpha were evaluated in all the patients and controls.
Gene_expression (production) of Th1 in mononuclear cell associated with inflammation and cytokine
7) Confidence 0.58 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18294814 Disease Relevance 0.22 Pain Relevance 1.07
Absence of 5-LO does not alter the development of IFN-gamma producing Th1-type CD4(+) T cells or IL-17 producing CD4(+) T cells.
Gene_expression (producing) of Th1 in T cells
8) Confidence 0.58 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18048478 Disease Relevance 0.87 Pain Relevance 0.66
Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.
Gene_expression (production) of Th1 associated with antidepressant, monoamine and cytokine
9) Confidence 0.58 Published 2006 Journal Eur Neuropsychopharmacol Section Title Doc Link 16388933 Disease Relevance 0.24 Pain Relevance 0.96
Before vaccination of these 6–35 month olds, an H1N1-specific response (data not shown) and a weak cross-reactive CD4 response against H5 (Figure 2) were detected, with both Th1 (IFN?)
Gene_expression (with) of Th1
10) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.09 Pain Relevance 0.08
Alterations in equilibrium between Th-1 and Th-2 responses have been linked to the pathogenesis of a wide variety of diseases such as IBD, IBS and allergies.
Gene_expression (responses) of Th-1 associated with inflammatory bowel disease, spastic colon, hypersensitivity and disease
11) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 1.16 Pain Relevance 0.36
Ratio between Th1 and Th2 response was calculated as ratio between concentrations of Th1 cytokines (IL-12 + IFN-?)
Gene_expression (cytokines) of Th1 associated with cytokine
12) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.20 Pain Relevance 0.14
[46] in TH1-like diseases, there was no elevation in IFN?
Gene_expression (diseases) of TH1-like associated with disease
13) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.97 Pain Relevance 0.45
This peptidomimetic compound was evaluated for its effect on purified protein derivative (PPD) stimulated lymphocyte proliferation in vitro, production of Th1 and Th2 cytokines by ELISA and ribonuclease protection assay.
Gene_expression (production) of Th1 in lymphocyte associated with cytokine
14) Confidence 0.46 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12095165 Disease Relevance 0.09 Pain Relevance 0.36
-producing Th1 cells, which have been associated with regulation of cell-mediated immunity.
Gene_expression (-) of Th1 in Th1 cells
15) Confidence 0.46 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.65 Pain Relevance 0.22
The expression of the classic Th1-associated cytokines IFN?
Gene_expression (expression) of Th1-associated associated with cytokine
16) Confidence 0.43 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.26 Pain Relevance 0.58
IL-12 has an essential role in Th1 development, stimulating activated T cells and NK cells to maximally produce IFN-?
Gene_expression (development) of Th1 in NK cells
17) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.41 Pain Relevance 0.12
Ratio between Th1 and Th2 response was calculated as ratio between concentrations of Th1 cytokines (IL-12 + IFN-?)
Gene_expression (response) of Th1 associated with cytokine
18) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.19 Pain Relevance 0.15
-producing Th1 cells, is produced predominantly by macrophages localized adjacent to lymphatic aggregates.
Gene_expression (producing) of Th1 in Th1 cells
19) Confidence 0.43 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.57 Pain Relevance 0.45
The reduced cortisol and adrenal androgen secretion, observed during testing in rheumatoid arthritis (RA) patients not treated with glucocoticoids, should be clearly considered as a "relative adrenal insufficiency" in the presence of a sustained inflammatory process, and allows Th1 type cytokines to be produced in higher amounts during the late night.
Gene_expression (produced) of Th1 associated with inflammation, rheumatoid arthritis, adrenal insufficiency and cytokine
20) Confidence 0.42 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16855156 Disease Relevance 0.86 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox