INT72672

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.81
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (APOA1) small molecule metabolic process (APOA1) extracellular region (APOA1)
plasma membrane (APOA1) enzyme binding (APOA1) transmembrane transport (APOA1)
Anatomy Link Frequency
brush 2
APOA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 46 97.12 Very High Very High Very High
aspirin 14 92.48 High High
agonist 7 82.56 Quite High
cINOD 3 54.52 Quite High
Pain 5 44.16 Quite Low
headache 4 26.36 Quite Low
backache 2 25.60 Quite Low
abdominal pain 2 24.72 Low Low
cva 14 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 357 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 30 97.80 Very High Very High Very High
Hyperlipidemia 25 93.84 High High
Apoptosis 4 92.84 High High
Pressure And Volume Under Development 8 91.88 High High
Coronary Artery Disease 186 82.64 Quite High
Colon Cancer 5 75.00 Quite High
Insulin Resistance 7 72.08 Quite High
Familial Adenomatous Polyposis 2 65.52 Quite High
Cancer 2 62.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of ApoAI or infusion of ApoA-I in animal models increases HDL-C levels and decreases atherosclerosis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ApoA-I associated with increased venous pressure under development and disorder of lipid metabolism
1) Confidence 0.67 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.07 Pain Relevance 0.08
The inhibition of growth is associated with a dose-dependent reduction in insulin-like growth factor II mRNA expression and with an increase in sucrase activity (a brush border enzyme) and apolipoprotein A-I mRNA expression, 2 specific markers of the differentiative status of this cell line.
Positive_regulation (increase) of Gene_expression (expression) of apolipoprotein A-I in brush associated with disorder of lipid metabolism
2) Confidence 0.49 Published 1997 Journal Int. J. Cancer Section Abstract Doc Link 9399670 Disease Relevance 0.76 Pain Relevance 0.33
Another potential target for raising HDL-C levels is augmenting ApoA-I levels (an important protein in HDL-C).
Positive_regulation (augmenting) of Gene_expression (levels) of ApoA-I associated with disorder of lipid metabolism
3) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.01 Pain Relevance 0.07
There was a minor increase in the apoB/apoA1 ratios in both groups (Figure 4).
Positive_regulation (increase) of Gene_expression (ratios) of apoA1
4) Confidence 0.30 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.46 Pain Relevance 0
The mechanism by which HDL is raised is through increased intestinal production of apoA-I [53].
Positive_regulation (increased) of Gene_expression (production) of apoA-I associated with disorder of lipid metabolism
5) Confidence 0.16 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1592077 Disease Relevance 0.51 Pain Relevance 0.41

General Comments

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