INT72673

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (APOA1) small molecule metabolic process (APOA1) extracellular region (APOA1)
plasma membrane (APOA1) enzyme binding (APOA1) transmembrane transport (APOA1)
Anatomy Link Frequency
plasma 1
brush 1
APOA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 8 92.48 High High
agonist 30 85.40 High High
cINOD 2 52.24 Quite High
Inflammation 14 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 15 100.00 Very High Very High Very High
Apoptosis 2 90.56 High High
Colon Cancer 5 75.00 Quite High
Obesity 14 74.96 Quite High
Familial Adenomatous Polyposis 2 63.24 Quite High
Cancer 2 60.24 Quite High
INFLAMMATION 17 52.00 Quite High
Nash(non-alcoholic Steatohepatitis) 3 5.00 Very Low Very Low Very Low
Fatty Liver 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of growth is associated with a dose-dependent reduction in insulin-like growth factor II mRNA expression and with an increase in sucrase activity (a brush border enzyme) and apolipoprotein A-I mRNA expression, 2 specific markers of the differentiative status of this cell line.
Transcription (expression) of apolipoprotein A-I in brush associated with disorder of lipid metabolism
1) Confidence 0.52 Published 1997 Journal Int. J. Cancer Section Abstract Doc Link 9399670 Disease Relevance 0.74 Pain Relevance 0.32
activation in mouse downregulates Apoa1 mRNA expression and plasma concentrations through an indirect pathway involving the PPAR?
Transcription (expression) of Apoa1 in plasma
2) Confidence 0.20 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.46 Pain Relevance 0.04

General Comments

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