INT72677

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 4
Speculated 5
Reported most in Body
Documents 45
Total Number 50
Disease Relevance 13.95
Pain Relevance 26.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 4
midbrain 4
hippocampus 4
sensory neuron 2
internal 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 1038 100.00 Very High Very High Very High
opioid receptor 485 100.00 Very High Very High Very High
Morphine 196 100.00 Very High Very High Very High
tolerance 64 100.00 Very High Very High Very High
agonist 32 100.00 Very High Very High Very High
Pain 21 100.00 Very High Very High Very High
Cannabinoid 13 100.00 Very High Very High Very High
analgesia 26 99.92 Very High Very High Very High
antinociception 8 99.92 Very High Very High Very High
Immobilon 31 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 76 100.00 Very High Very High Very High
Sprains And Strains 35 99.98 Very High Very High Very High
Repression 106 99.80 Very High Very High Very High
Burns 364 99.50 Very High Very High Very High
INFLAMMATION 30 99.50 Very High Very High Very High
Cv Unclassified Under Development 10 99.26 Very High Very High Very High
Targeted Disruption 108 98.68 Very High Very High Very High
Pain 14 98.44 Very High Very High Very High
Disease 43 98.00 Very High Very High Very High
Injury 21 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of genetic variation affecting OPRM1 expression or mu opioid receptor function would be an important step towards understanding the origins of inter-individual variation in response to mu opioid receptor ligands and in diseases of substance dependence.
Regulation (affecting) of Gene_expression (expression) of mu opioid receptor associated with drug dependence, addiction, mu opioid receptor and disease
1) Confidence 0.62 Published 1997 Journal Mol. Psychiatry Section Abstract Doc Link 9399694 Disease Relevance 0.36 Pain Relevance 1.10
In this study, we demonstrate that the 24-h variation in circulating glucocorticoid levels modulates the analgesic effect of morphine by regulating the expression of the mu-opioid receptor.
Regulation (regulating) of Gene_expression (expression) of mu-opioid receptor associated with analgesic, opioid receptor and morphine
2) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16109741 Disease Relevance 0.09 Pain Relevance 0.77
These data are the first demonstration of in vivo homologous regulation of mu-opioid receptor gene expression in the mouse by an opioid receptor agonist that produces tolerance and receptor downregulation.
Regulation (regulation) of Gene_expression (expression) of mu-opioid receptor associated with tolerance, agonist and opioid receptor
3) Confidence 0.61 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9450614 Disease Relevance 0 Pain Relevance 0.93
In vivo homologous regulation of mu-opioid receptor gene expression in the mouse.
Regulation (regulation) of Gene_expression (expression) of mu-opioid receptor associated with opioid receptor and immobilon
4) Confidence 0.61 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9450614 Disease Relevance 0 Pain Relevance 1.16
Ribosome leaky scanning regulates mouse MOR gene expression
Regulation (regulates) of Gene_expression (expression) of MOR gene associated with mu opioid receptor
5) Confidence 0.55 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0.08
Detection of genetic variation affecting OPRM1 expression or mu opioid receptor function would be an important step towards understanding the origins of inter-individual variation in response to mu opioid receptor ligands and in diseases of substance dependence.
Regulation (affecting) of Gene_expression (expression) of OPRM1 associated with drug dependence, addiction, mu opioid receptor and disease
6) Confidence 0.45 Published 1997 Journal Mol. Psychiatry Section Abstract Doc Link 9399694 Disease Relevance 0.36 Pain Relevance 1.09
Strain conferred a performance advantage in all groups, with the exception of Oprm1?
Neg (exception) Regulation (conferred) of Neg (exception) Gene_expression (exception) of Oprm1 associated with sprains and strains
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 1.24 Pain Relevance 0.45
Several lines of evidence have suggested that the level of opioid-induced analgesia is dependent on the level of expression of the mu-opioid receptor (mu-OR).
Regulation (dependent) of Gene_expression (expression) of mu-OR associated with opioid receptor, opioid and analgesia
8) Confidence 0.45 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11160404 Disease Relevance 0 Pain Relevance 0.76
Several lines of evidence have suggested that the level of opioid-induced analgesia is dependent on the level of expression of the mu-opioid receptor (mu-OR).
Regulation (dependent) of Gene_expression (expression) of mu-opioid receptor associated with opioid receptor, opioid and analgesia
9) Confidence 0.45 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11160404 Disease Relevance 0 Pain Relevance 0.75
RATIONALE: Differences in mu-opiate receptor (MOR) gene expression may modulate the rewarding effects of ethanol.
Regulation (modulate) of Gene_expression (expression) of MOR associated with opiate
10) Confidence 0.45 Published 2001 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11292005 Disease Relevance 0.07 Pain Relevance 0.17
CP2-KL (Fig. 6D) constructs all up-regulated endogenous Oprm1 gene expression in a dose-dependent manner.
Regulation (regulated) of Gene_expression (expression) of Oprm1
11) Confidence 0.45 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0.04
These uORFs have the potential to exert a major impact on MOR gene expression, and some, but not all, serve as important regulatory elements under normal conditions.



Regulation (impact) of Gene_expression (expression) of MOR gene associated with mu opioid receptor
12) Confidence 0.40 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.09 Pain Relevance 0.31
These results suggest that uORFs can negatively regulate MOR expression.


Regulation (regulate) of Gene_expression (expression) of MOR associated with mu opioid receptor
13) Confidence 0.40 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.25 Pain Relevance 0.47
Briefly, after transient transfection with the indicated constructs, confirmation of MOR expression was determined by a whole-cell binding assay using [3H]diprenorphine in 25?
Regulation (confirmation) of Gene_expression (expression) of MOR associated with mu opioid receptor
14) Confidence 0.40 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0.05
The results confirmed that these uORFs mediated down-regulation of MOR expression.
Regulation (regulation) of Gene_expression (expression) of MOR associated with mu opioid receptor
15) Confidence 0.40 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.09 Pain Relevance 0.20
Because two short isoforms are generated by internal start codon, it can be speculated that the N-terminal region (112 amino acid residues) of Sp3, which is absent from the two short isoforms, takes responsibility for the interaction of the full-length Sp3 with NRSF and for determining the role of Sp3 factors for MOR gene expression.
Spec (determining) Regulation (role) of Gene_expression (expression) of MOR in internal associated with mu opioid receptor
16) Confidence 0.38 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.05 Pain Relevance 0.16
However, our current and previous data strongly suggest that the regulatory action of Sp3 factors is promoter- and cellular context dependent at least in the MOR gene expression because (i) only the full-length Sp3 can interact with NRSF in co-immunoprecipitation experiment whereas all three isoforms of Sp3 are expressed in NS20Y cells (Figure 4C), (ii) two short isoforms of Sp3 act as repressors by binding to the promoter element located at ?
Regulation (dependent) of Gene_expression (expression) of MOR in NS20Y associated with mu opioid receptor
17) Confidence 0.38 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.17 Pain Relevance 0.19
Under these conditions, no change in the G-protein activation by morphine and mu-opioid receptor expression in the lower midbrain was observed by prenatal and neonatal exposure to BPA.
Neg (no) Regulation (change) of Gene_expression (expression) of mu-opioid receptor in midbrain associated with midbrain, opioid receptor and morphine
18) Confidence 0.35 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14746872 Disease Relevance 0.09 Pain Relevance 0.54
l of immunoprecipitated chromatin sample with the primers spanning mouse MOR promoter region in 50 ?
Regulation (spanning) of Gene_expression (region) of MOR promoter associated with mu opioid receptor
19) Confidence 0.34 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.17
Here, we examined the effects of single and repeated stress on MOR mRNA expression in different rat brain regions using reverse transcriptase-polymerase chain reaction (RT-PCR).
Spec (examined) Regulation (effects) of Gene_expression (expression) of MOR mRNA in brain associated with stress and mu opioid receptor
20) Confidence 0.32 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867258 Disease Relevance 0.54 Pain Relevance 0.46

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