INT72703

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 79
Total Number 95
Disease Relevance 45.04
Pain Relevance 4.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
blood 7
liver 5
brain 5
plasma 4
muscle 4
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 440 100.00 Very High Very High Very High
Parenteral administration 16 99.92 Very High Very High Very High
alcohol 54 99.56 Very High Very High Very High
agonist 67 98.88 Very High Very High Very High
Eae 50 98.68 Very High Very High Very High
vagus nerve 28 97.12 Very High Very High Very High
withdrawal 6 96.88 Very High Very High Very High
substance P 99 95.04 Very High Very High Very High
cINOD 92 94.24 High High
amygdala 63 92.72 High High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 375 100.00 Very High Very High Very High
Insulin Resistance 133 100.00 Very High Very High Very High
Obesity 300 99.90 Very High Very High Very High
Targeted Disruption 1038 99.84 Very High Very High Very High
Diabetes Mellitus 819 99.84 Very High Very High Very High
Hyperinsulinism 55 99.80 Very High Very High Very High
Disease 1891 99.72 Very High Very High Very High
Alzheimer's Dementia 1035 99.60 Very High Very High Very High
Hyperglycemia 49 99.58 Very High Very High Very High
Hepatotoxicity 2 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, the overexpression of IDE in transgenic mice results in drastically reduced brain A?
Gene_expression (overexpression) of IDE in brain associated with targeted disruption
1) Confidence 0.70 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.55 Pain Relevance 0.06
Generally, the parenteral administration of insulin produces maximal fall in blood glucose levels within 20–30 min [4].
Gene_expression (produces) of insulin in blood associated with parenteral administration
2) Confidence 0.65 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.05
Hence, the C-peptide measurement reflects the absolute status of endogenous insulin production.
Gene_expression (production) of insulin
3) Confidence 0.65 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.13 Pain Relevance 0
In this animal model, the above observation further confirms the view that higher doses of exogenously administered insulin reflexly stimulate the synthesis of insulin which resulted in release of C-peptide.
Gene_expression (synthesis) of insulin
4) Confidence 0.65 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.15 Pain Relevance 0
Increased expression of an endopeptidase (gamma-EGE/IDE) hydrolyzing beta-endorphin during differentiation and maturation of bone marrow macrophages.
Gene_expression (expression) of IDE in macrophages
5) Confidence 0.58 Published 1997 Journal J. Leukoc. Biol. Section Title Doc Link 9400816 Disease Relevance 0 Pain Relevance 0.09
We observed that serum insulin levels were not altered with the lowest dose of insulin (2 ?
Gene_expression (levels) of insulin
6) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
But with the higher doses of insulin (2 m and 2 U/kg), the serum insulin levels were significantly elevated (P < 0.01) (Fig 3).
Gene_expression (levels) of insulin
7) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
In fact, it was emphasized that insulin injection could be used as a challenge to test the functional integrity of vagus fibers to the stomach.
Gene_expression (injection) of insulin in stomach
8) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.05
The available literature indicates that insulin produces a transitory inhibition followed by marked increase in tonus in the gastrointestinal smooth muscle [23].
Gene_expression (produces) of insulin in smooth muscle
9) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
To further elucidate the role of endogenous insulin levels on SIT with higher doses of insulin, we evaluated C-peptide of insulin levels.
Gene_expression (levels) of insulin
10) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
Charcoal meal was administered (i.g) 30 min after insulin administration and SIT was determined after 50 min.
Gene_expression (administration) of insulin
11) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.12 Pain Relevance 0
To further elucidate the role of endogenous insulin levels on SIT with higher doses of insulin, we evaluated C-peptide of insulin levels.
Gene_expression (levels) of insulin
12) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
But with the higher doses of insulin (2 m and 2 U/kg), the serum insulin levels were significantly elevated (P < 0.01) (Fig 3).
Gene_expression (doses) of insulin
13) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
We observed that serum insulin levels were not altered with the lowest dose of insulin (2 ?
Gene_expression (dose) of insulin
14) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
In our experiment, blood glucose levels were not affected with lower doses of insulin (2 ?
Gene_expression (doses) of insulin in blood
15) Confidence 0.57 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.06
A study using AD transgenic mice that had an over expression of IDE or NEP demonstrated a significant reduction in A?
Gene_expression (expression) of IDE associated with targeted disruption and disease
16) Confidence 0.56 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.74 Pain Relevance 0
degrading enzymes such as neprilysin (NEP) and insulin-degrading enzyme (IDE), have been suggested as potential methods of reducing the level of existing A?
Gene_expression (enzyme) of insulin-degrading
17) Confidence 0.55 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.69 Pain Relevance 0
It has been shown in animal models that reduction in both neprilysin and IDE expression in the brain correlated with increased A?
Gene_expression (expression) of IDE in brain
18) Confidence 0.52 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.61 Pain Relevance 0
These findings indicate that exogenously administered insulin is solely responsible for significant acceleration of SIT, but with the higher doses of insulin elevated endogenous insulin levels produced cannot be ruled out in acceleration of SIT.
Neg (cannot) Gene_expression (produced) of insulin
19) Confidence 0.51 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.07 Pain Relevance 0
Insulin at the lowest dose produced an acceleratory effect on SIT that was independent of blood glucose and serum insulin levels in normal mice.



Gene_expression (produced) of Insulin in blood
20) Confidence 0.51 Published 2006 Journal BMC Pharmacol Section Abstract Doc Link PMC1444921 Disease Relevance 0.32 Pain Relevance 0

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