INT72710

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Context Info
Confidence 0.10
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
transcription factor binding (Foxm1) cytoplasm (Foxm1)
Anatomy Link Frequency
brain 2
Foxm1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 26 99.50 Very High Very High Very High
Cannabinoid 32 99.02 Very High Very High Very High
Potency 2 81.40 Quite High
Inflammation 14 78.00 Quite High
Hippocampus 4 75.00 Quite High
noradrenaline 3 75.00 Quite High
cytokine 10 65.60 Quite High
agonist 8 61.96 Quite High
Cannabinoid receptor 22 61.60 Quite High
fibrosis 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 44 94.16 High High
Glioma 2 75.00 Quite High
Apoptosis 11 60.12 Quite High
Death 2 52.76 Quite High
INFLAMMATION 15 50.00 Quite Low
Fibrosis 11 50.00 Quite Low
Necrosis 3 44.44 Quite Low
Pancreatitis 32 10.96 Low Low
Cirrhosis 15 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SR 141716 (0.32 microM) markedly attenuated the WIN 55,212-2-induced inhibition in guinea-pig and human brain slices.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of WIN in brain
1) Confidence 0.10 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9402037 Disease Relevance 0 Pain Relevance 0.20
The cannabinoid CB1 receptor antagonist, SR141716A (0.1-100 nM), but not the cannabinoid CB2 receptor antagonist, SR144528 (0.1-100 nM), reduced in a dose-related manner WIN 55,212-2-and cannabinol-induced inhibition of nitrite production.
Negative_regulation (reduced) of Negative_regulation (inhibition) of WIN associated with antagonist and cannabinoid
2) Confidence 0.03 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11520904 Disease Relevance 0.14 Pain Relevance 0.42
Pre-incubation with AM251 and/or AM630 (5 ┬ÁM) revealed that the suppressive effect of WIN on fibronectin and collagen 1 production was partially reversible only when using both antagonists concomitantly (Figure 7B; pooled cell culture supernatanty from three independently performed experiments).
Spec (partially) Negative_regulation (reversible) of Negative_regulation (effect) of WIN associated with antagonist
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.40 Pain Relevance 0.22

General Comments

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