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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.55
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppc) extracellular region (Nppc)
Anatomy Link Frequency
anterior 1
Schwann cells 1
Nppc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 4 98.98 Very High Very High Very High
Pain 2 97.32 Very High Very High Very High
Spinal cord 1 91.92 High High
dorsal root ganglion 5 89.88 High High
algogenic 1 88.08 High High
qutenza 5 75.00 Quite High
nociceptor 3 75.00 Quite High
Peripheral nervous system 1 60.92 Quite High
antagonist 3 50.64 Quite High
substance P 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 1 97.32 Very High Very High Very High
Nociception 10 96.64 Very High Very High Very High
Ganglion Cysts 5 89.88 High High
Diabetes Mellitus 54 88.36 High High
Hypoglycemia 6 79.72 Quite High
Natriuresis 8 75.00 Quite High
Coronary Heart Disease 1 67.84 Quite High
Coronary Stenosis 1 50.00 Quite Low
Bordatella Infection 2 35.36 Quite Low
Diarrhoea 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that CNP is derived from Schwann cells and plays an important role for the development and function of nociceptive sensory neurones.
Positive_regulation (derived) of CNP in Schwann cells associated with nociception
1) Confidence 0.39 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18752656 Disease Relevance 0.70 Pain Relevance 0.36
Nociceptin/orphanin FQ (N/OFQ), nocistatin, and prepro-N/OFQ 160-187 (C-peptide) are all derived from the same precursor protein.
Positive_regulation (derived) of C-peptide associated with orphanin
2) Confidence 0.04 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12665541 Disease Relevance 0.23 Pain Relevance 0.51
Further, the 2 m and 2 U doses of insulin significantly elevated serum insulin and C-peptide levels.

Positive_regulation (elevated) of C-peptide
3) Confidence 0.04 Published 2006 Journal BMC Pharmacol Section Abstract Doc Link PMC1444921 Disease Relevance 0.33 Pain Relevance 0
Surprisingly, we noticed that C-peptide levels in serum were significantly elevated with higher doses of insulin administration (P < 0.01) (2 m and 2 U/kg) (Table 1).
Positive_regulation (elevated) of C-peptide
4) Confidence 0.04 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.14 Pain Relevance 0
To further elucidate the role of endogenous insulin levels on SIT with higher doses of insulin, we evaluated C-peptide of insulin levels.
Positive_regulation (evaluated) of C-peptide
5) Confidence 0.03 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
As expected, left ventricular end-diastolic pressure and disease of left anterior descending and circumflex coronary arteries were associated with increased resting B-type natriuretic peptide levels.
Positive_regulation (increased) of B-type natriuretic peptide in anterior
6) Confidence 0.02 Published 1997 Journal Eur. Heart J. Section Body Doc Link 9402449 Disease Relevance 0.07 Pain Relevance 0

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