INT72717

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.25
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppc) extracellular region (Nppc)
Anatomy Link Frequency
blood 1
Plasma 1
endothelial cells 1
smooth muscle cells 1
Nppc (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 14 99.12 Very High Very High Very High
tolerance 17 95.40 Very High Very High Very High
Cholecystokinin 1 73.44 Quite High
Chronic pancreatitis 2 38.64 Quite Low
agonist 3 27.92 Quite Low
Inflammation 28 21.04 Low Low
vagus nerve 1 13.60 Low Low
cva 24 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 24 100.00 Very High Very High Very High
Insulin Resistance 20 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 289 99.46 Very High Very High Very High
Increased Venous Pressure Under Development 7 99.40 Very High Very High Very High
Cv General 3 Under Development 6 99.12 Very High Very High Very High
Coronary Heart Disease 14 97.12 Very High Very High Very High
Diabetes Mellitus 48 96.12 Very High Very High Very High
Impaired Glucose Tolerance 17 95.40 Very High Very High Very High
Ischemic Heart Disease 2 95.32 Very High Very High Very High
Left Ventricular Dysfunction 2 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, objective diagnostic testing with cardiac catheterization, Doppler echocardiography, and possibly measurement of serum levels of B-type natriuretic peptide is often required.
Gene_expression (levels) of B-type natriuretic peptide associated with natriuresis
1) Confidence 0.51 Published 2004 Journal Am. J. Crit. Care Section Abstract Doc Link 15568651 Disease Relevance 1.08 Pain Relevance 0.08
Finally, HDL was shown to modulate the synthesis of CNP, which causes vasodilatation, inhibits proliferation of smooth muscle cells, and inhibits ET-1 secretion (Sugiyama et al 1995).
Gene_expression (synthesis) of CNP in smooth muscle cells associated with increased venous pressure under development and disorder of lipid metabolism
2) Confidence 0.33 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.00 Pain Relevance 0
Moreover, suppression of CNP synthesis in the presence of Ox-LDL is antagonized by HDL.


Gene_expression (synthesis) of CNP associated with disorder of lipid metabolism
3) Confidence 0.29 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.03 Pain Relevance 0
We also measured insulin resistance, serum glucose, C-peptide, insulin, pancreatic RNA digestive enzyme expression, and PMBF (microsphere technique).
Gene_expression (resistance) of C-peptide associated with insulin resistance
4) Confidence 0.07 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510194 Disease Relevance 0.40 Pain Relevance 0.04
To further elucidate the role of endogenous insulin levels on SIT with higher doses of insulin, we evaluated C-peptide of insulin levels.
Gene_expression (levels) of C-peptide
5) Confidence 0.05 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
C-type natriuretic peptide (CNP) is produced by vascular endothelial cells and the kidney and is structurally similar to ANP and BNP.
Gene_expression (produced) of C-type natriuretic peptide in endothelial cells associated with natriuresis
6) Confidence 0.03 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824858 Disease Relevance 0.60 Pain Relevance 0
We investigated exercise levels of atrial natriuretic peptide and B-type natriuretic peptide in patients with suspected angina to determine whether these measurements could improve non-invasive assessment of coronary disease severity.
Spec (investigated) Gene_expression (levels) of B-type natriuretic peptide associated with natriuresis, angina and coronary heart disease
7) Confidence 0.03 Published 1997 Journal Eur. Heart J. Section Abstract Doc Link 9402449 Disease Relevance 1.03 Pain Relevance 0.10
Plasma levels of atrial natriuretic peptide and B-type natriuretic peptide were measured at rest and at peak exercise.
Gene_expression (levels) of B-type natriuretic peptide in Plasma
8) Confidence 0.03 Published 1997 Journal Eur. Heart J. Section Body Doc Link 9402449 Disease Relevance 0.09 Pain Relevance 0
Subjects with IGT and newly diagnosed type-2 diabetes were similar in age and had significantly higher fasting and post-lunch blood glucose (P < 0.0001, P < 0.0001, respectively), and not significantly higher fasting and post-lunch serum insulin, C-peptide, abnormal lipid profile, and HOMA-IR levels compared with nondiabetic subjects.
Gene_expression (levels) of C-peptide in blood associated with diabetes mellitus and tolerance
9) Confidence 0.01 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.94 Pain Relevance 0.17

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