INT72734

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 3.18
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syt17) molecular_function (Syt17) biological_process (Syt17)
Anatomy Link Frequency
Golgi cells 2
sciatic nerve 1
nerve 1
Purkinje cells 1
limb 1
Syt17 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 25 100.00 Very High Very High Very High
agonist 6 99.62 Very High Very High Very High
B1 receptor 8 99.46 Very High Very High Very High
Somatostatin 27 99.32 Very High Very High Very High
potassium channel 18 99.24 Very High Very High Very High
Sciatic nerve 4 98.40 Very High Very High Very High
Hyperalgesia 2 96.28 Very High Very High Very High
Pain 5 95.60 Very High Very High Very High
unmyelinated 4 92.92 High High
dorsal root ganglion 10 90.88 High High
Disease Link Frequency Relevance Heat
Nociception 15 99.96 Very High Very High Very High
Hyperalgesia 2 96.28 Very High Very High Very High
Pain 2 95.60 Very High Very High Very High
Ataxia 189 95.24 Very High Very High Very High
Ganglion Cysts 10 90.88 High High
Shock 9 84.60 Quite High
Depression 9 80.08 Quite High
Nervous System Injury 6 75.00 Quite High
Bordatella Infection 1 55.92 Quite High
Congenital Anomalies 9 44.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bradykinin (BK) given into the plantar (i.pl.) of the mouse hind-limb produced a flexor response.
Gene_expression (produced) of BK in limb associated with bradykinin
1) Confidence 0.52 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9404952 Disease Relevance 0.13 Pain Relevance 0.82
Using a highly sensitive nociception test, we found that intraplantar (i.pl.) injection of BK produced nociceptive hyper-responses in partial sciatic nerve-injured mice, compared with the control sham-operated animals.
Gene_expression (produced) of BK in sciatic nerve associated with nociception, sciatic nerve and bradykinin
2) Confidence 0.21 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 0.76 Pain Relevance 0.80
The B1 receptor agonist, [Lys-des-Arg(9)]-BK also produced nociceptive response and activated ERK only in nerve-injured mice.
Gene_expression (produced) of BK in nerve associated with nociception, b1 receptor, agonist and bradykinin
3) Confidence 0.21 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 1.13 Pain Relevance 1.26
To further understand how BK channels affect PC firing properties, and thus cerebellar function, mice deficient in the BK channel (BK?
Gene_expression (channels) of BK
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.14 Pain Relevance 0.04
The slices were then washed with TBS and incubated overnight with anti-BK?
Gene_expression (washed) of BK
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.08 Pain Relevance 0.08
To further understand how BK channels affect PC firing properties, and thus cerebellar function, mice deficient in the BK channel (BK?
Gene_expression (channel) of BK
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.15 Pain Relevance 0.04
To further understand how BK channels affect PC firing properties, and thus cerebellar function, mice deficient in the BK channel (BK?
Gene_expression (channel) of BK
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.15 Pain Relevance 0.04
After rinsing with TBS, slices were incubated with an Alexa555-coupled donkey anti-rabbit IgG (Molecular Probes,Carlsbad, CA) for BK channel detection and with an Alexa488-coupled donkey anti-goat IgG (Molecular Probes) for somatostatin detection.
Gene_expression (detection) of BK associated with somatostatin
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.07 Pain Relevance 0.09
We confirmed BK expression in Purkinje cells and also demonstrated it in Golgi cells.
Gene_expression (expression) of BK in Golgi cells
9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2776494 Disease Relevance 0.09 Pain Relevance 0.05
However, the contribution of other cerebellar cells such as granule cells, which also express BK channels [49] or the implication of other regulatory mechanisms cannot be ruled out by the present study.
Gene_expression (express) of BK in granule cells
10) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.39 Pain Relevance 0
We studied the electrophysiological behavior of Purkinje cells in genetically engineered alert mice that do not express BK calcium-activated potassium channels and in wild-type mice with pharmacological BK inactivation.
Neg (not) Gene_expression (express) of BK in Purkinje cells associated with potassium channel
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2776494 Disease Relevance 0.08 Pain Relevance 0.05
Immunohistochemistry of the cerebellar cortex revealed that Golgi cells, identified by positive somatostatin staining as a marker [12], [13], express BK channels (Fig. 4A–C).
Gene_expression (express) of BK in Golgi cells associated with somatostatin
12) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0 Pain Relevance 0.05

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