INT72743

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1997
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
neurons 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 18 99.98 Very High Very High Very High
dorsal root ganglion 11 99.30 Very High Very High Very High
tetrodotoxin 2 98.48 Very High Very High Very High
Opioid 127 98.46 Very High Very High Very High
Inflammation 65 98.08 Very High Very High Very High
Neurotransmitter 2 96.24 Very High Very High Very High
opioid receptor 94 90.88 High High
Endogenous opioid 37 81.44 Quite High
Calcium channel 1 79.56 Quite High
tissue acidosis 2 77.36 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 147 99.98 Very High Very High Very High
Ganglion Cysts 12 99.30 Very High Very High Very High
INFLAMMATION 70 98.08 Very High Very High Very High
Acidosis 4 77.36 Quite High
Pain 38 50.00 Quite Low
Urological Neuroanatomy 5 47.12 Quite Low
Stress 18 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 15 5.00 Very Low Very Low Very Low
Adhesions 13 5.00 Very Low Very Low Very Low
Nociception 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockage of the Ca2+-ATPase pump, which inhibits the extrusion of calcium, plays a significant role in the process and enhances CIC.
Positive_regulation (enhances) of Negative_regulation (Blockage) of Ca2
1) Confidence 0.49 Published 2001 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11903504 Disease Relevance 0 Pain Relevance 0.24
These data indicate that anoxia causes a slow depletion of ER Ca2+ store content.
Positive_regulation (causes) of Negative_regulation (depletion) of Ca2 associated with hypoxia
2) Confidence 0.43 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.76 Pain Relevance 0
Verapamil and nifedipine which block voltage-gated Ca2+ channels, did not alter Ca2+ uptake stimulated by glucose deprivation, indicating that glucose deprivation-enhanced Ca2+ uptake was not mediated by Ca2+ channels.
Neg (not) Positive_regulation (mediated) of Negative_regulation (deprivation) of Ca2
3) Confidence 0.40 Published 1997 Journal Mol. Cell. Biochem. Section Abstract Doc Link 9406177 Disease Relevance 0.08 Pain Relevance 0.10
Further evidence that acidic inflammatory pH improves opioid efficacy is provided by studies using DRG neurons, which show that morphine inhibition of Ca2+ transients is enhanced at low extracellular pH (Kapitzke et al 2005).
Positive_regulation (enhanced) of Negative_regulation (inhibition) of Ca2 in neurons associated with dorsal root ganglion, inflammation, opioid and morphine
4) Confidence 0.04 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.57 Pain Relevance 1.77

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox