INT72747

Context Info Confidence 0.53 First Reported 1997 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 55 Total Number 56 Disease Relevance 30.88 Pain Relevance 4.19

Anatomy Link Frequency B cells 3 blood 2 nasal 2 plasma 1 plasma cell 1 IgG (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 323 99.84 cINOD 7 97.60 Spinal cord 117 95.60 anesthesia 26 94.80 Multiple sclerosis 49 94.00 Arthritis 181 92.88 Neuritis 56 90.44 imagery 13 90.04 methotrexate 5 89.84 dexamethasone 6 89.64

Disease Link Frequency Relevance Heat Neuromyelitis Optica 544 100.00 Togavirus Infection 70 100.00 Anaerobic Bacterial Infections 16 100.00 Immunization 234 99.88 Rheumatoid Arthritis 324 99.84 Papillomavirus Infection 10 99.84 Severe Combined Immunodeficiency 2 99.32 Demyelinating Disease 46 99.24 Mycobacterial Infection 31 99.10 Fever 58 99.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The injected IgG was found in the axon terminals of the lumbar ventral horn motor neurons, localizing in the microtubules and rough endoplasmic reticulum.

Localization (localizing) of IgG in reticulum

1) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.60 Pain Relevance 0.24

If they were pregnant, IgG avidity testing is the preferred method to confirm recent infection,34 because IgM antibodies can persist for months after initial infection in some individuals.35,36 Alternate testing algorithms use higher IgM serologic titers as good indicators of acute infection when economic considerations preempt additional tests.37,38

Localization (testing) of IgG associated with togavirus infection and infection

2) Confidence 0.51 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2844547 Disease Relevance 1.03 Pain Relevance 0

CONCLUSIONS: A radioisotope label on IgG and its visualization in a large series of animal models indicate that a low protein dose of anti-GD2 IgG will not cause neurologic side effects in patients.

Localization (visualization) of IgG

3) Confidence 0.46 Published 1997 Journal Cancer Section Body Doc Link 9406719 Disease Relevance 0 Pain Relevance 0

When dimerized with J chain, IgA is actively transported by the polymeric Ig receptor (pIgR) system through the columnar epithelium of conducting airways and is therefore more abundant than IgG in secretions of upper than lower airways [27,28].

Localization (secretions) of IgG in epithelium

4) Confidence 0.35 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.09 Pain Relevance 0

After its release into airway secretions, secretory M2e(pep-nat)-specific IgA may have lesser protective power than IgG, both in terms of activation of FcR-expressing effector cells and complement.

Localization (release) of IgG

5) Confidence 0.35 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.10 Pain Relevance 0

Measurement of sera IgG

Localization (Measurement) of IgG

6) Confidence 0.34 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.12

For blocking of the cytolytic activity the NK specific antibodies directed against NKp30, NKp44, NKp46 (Immunotech, Marseille, France) and the antibodies directed against Hsp70 (cmHsp70.2, multimmune GmbH) and MICA/B (BAMO1, IgG1; BAMO2, IgG2a, Bamomab, Munich, Germany) on tumor cells were used.

Localization (directed) of IgG1 associated with cancer

7) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.38 Pain Relevance 0

The FcRn binds pinocytosed IgG only in the acidic environment of the endosome and releases intact IgG when its transport vesicle is redirected to the neutral pH of the cell surface.

Localization (releases) of IgG in vesicle

8) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.89 Pain Relevance 0.19

The occurrence of elevated levels of rheumatoid factors (RFs), which are autoantibodies against the Fc portion of IgG molecules, are a diagnostic marker for RA, even though they are not specific for the disease.

Localization (portion) of IgG associated with rheumatoid arthritis and disease

9) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.41 Pain Relevance 0.55

Immunofluorescent antibody staining showed large amounts of both complement protein C3 and IgG in the glomerular mesangium and in the capillary loops (data not shown).

Localization (amounts) of IgG in capillary

10) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.57 Pain Relevance 0.06

Using this method, both anti-CCP IgG and anti-tetanus IgG as well as total IgM and IgG were found to be significantly enriched in RA synovia, whereas the value for RF-IgM did not differ significantly from 1.

Localization (enriched) of IgG associated with rheumatoid arthritis and anaerobic bacterial infections

11) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.50 Pain Relevance 0.17

Using this method, both anti-CCP IgG and anti-tetanus IgG as well as total IgM and IgG were found to be significantly enriched in RA synovia, whereas the value for RF-IgM did not differ significantly from 1.

Localization (enriched) of IgG associated with rheumatoid arthritis and anaerobic bacterial infections

12) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.50 Pain Relevance 0.17

They all had a lower concentration of one or more classes of serum immunoglobulin (IgG, IgM and IgA) than the standard control ranges, and their mean concentration of IgG was significantly lower (P<0.005) than the mean concentration of IgG in 15 clinically normal weimaraners.

Localization (concentration) of IgG

13) Confidence 0.28 Published 2003 Journal Vet. Rec. Section Abstract Doc Link 14627235 Disease Relevance 1.07 Pain Relevance 0.16

IgM and IgG subclasses were detected using mouse immunoglobulin isotype specific monoclonal antibodies : anti-IgM IgG2a,?

Localization (subclasses) of IgG

14) Confidence 0.27 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0

Representative examples of the data showing IgM responses after primary immunisation, and IgG responses after secondary immunisation, are shown in fig 6 (immunization with 6 ?

Localization (responses) of IgG associated with immunization

15) Confidence 0.27 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0.30 Pain Relevance 0

To analyze antibody secretion from sorted YFP+ or plasma cell populations, mouse IgG capture antibodies were coated onto a PVDF-backed microplate.

Spec (analyze) Localization (secretion) of IgG in plasma cell

16) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.07 Pain Relevance 0

We tested the ability of vaults expressing (cp-MVP-z) or lacking (cp-MVP) the Fc binding peptide to adhere to mouse Ig isotypes which are generally found in nasal secretions (IgG and IgA) using an ELISA assay.

Localization (secretions) of IgG in nasal associated with mitral valve prolapse

17) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.93 Pain Relevance 0

After 4 hours incubation at room temperature, the plates were washed (3 times), and the concentrations of IgG subclass Abs were determined by the addition 100 ?

Localization (concentrations) of IgG

18) Confidence 0.18 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.08 Pain Relevance 0

In addition, the M2-transduced B cells secreted significantly higher levels of IgG on days 4–6 post-transduction than the cells transduced with the control retrovirus (Figure 3B).

Localization (secreted) of IgG in B cells

19) Confidence 0.17 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.08 Pain Relevance 0

EBV encodes a viral IL-10 homolog, BCRF1 (or vIL-10), that has been shown to increase human B cell proliferation following surface immunoglobulin crosslinkinking and induce B cells to secrete increased levels of IgM, IgG, and IgA in a similar manner to cellular IL-10 [17].

Localization (secrete) of IgG in B cells associated with epstein-barr virus

20) Confidence 0.17 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.69 Pain Relevance 0

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