INT72754

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Context Info
Confidence 0.28
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.64
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Adamts7, TNF) signal transduction (TNF) extracellular space (TNF)
peptidase activity (Adamts7) proteinaceous extracellular matrix (Adamts7) plasma membrane (TNF)
Anatomy Link Frequency
nerve 1
Adamts7 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 2 97.92 Very High Very High Very High
Eae 5 96.96 Very High Very High Very High
allodynia 3 89.40 High High
Thermal hyperalgesia 3 88.40 High High
withdrawal 1 77.76 Quite High
Pain 3 75.00 Quite High
Hyperalgesia 1 71.12 Quite High
Inflammation 1 51.76 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 99.44 Very High Very High Very High
Neuropathic Pain 6 97.92 Very High Very High Very High
Injury 6 96.96 Very High Very High Very High
Hyperalgesia 4 88.40 High High
Pain 2 75.00 Quite High
INFLAMMATION 1 51.76 Quite High
Necrosis 1 49.16 Quite Low
Cancer 1 48.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the metalloprotease inhibitor TAPI specifically reduces endoneurial TNF-levels after nerve injury and thereby may diminish neuropathic pain in the CCI-model.
metalloprotease Negative_regulation (reduces) of TNF in nerve associated with nervous system injury, eae and neuropathic pain
1) Confidence 0.28 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9406876 Disease Relevance 1.64 Pain Relevance 1.13

General Comments

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