INT72755

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.45
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tap1, TNF) transport (Tap1) mitochondrion (Tap1)
endoplasmic reticulum (Tap1) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 1
T-cells 1
Tap1 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 4 97.44 Very High Very High Very High
Inflammation 2 96.60 Very High Very High Very High
Pain 6 89.44 High High
Eae 10 86.56 High High
Hyperalgesia 2 76.16 Quite High
withdrawal 2 62.72 Quite High
Thermal hyperalgesia 6 59.36 Quite High
allodynia 6 54.24 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 12 97.44 Very High Very High Very High
INFLAMMATION 2 96.60 Very High Very High Very High
Necrosis 2 94.00 High High
Cancer 2 93.64 High High
Pain 4 89.44 High High
Injury 12 84.88 Quite High
Hyperalgesia 8 76.16 Quite High
Nervous System Injury 4 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synthetic hydroxamic acid based metalloprotease inhibitor TAPI blocks cleavage of cell surface TNF and thus reduces levels of the mature 17-kDa TNF polypeptide in activated macrophages and T-cells.
TAPI Negative_regulation (reduces) of TNF in T-cells
1) Confidence 0.43 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9406876 Disease Relevance 1.22 Pain Relevance 0.73
The synthetic hydroxamic acid based metalloprotease inhibitor TAPI blocks cleavage of cell surface TNF and thus reduces levels of the mature 17-kDa TNF polypeptide in activated macrophages and T-cells.
TAPI Negative_regulation (reduces) of TNF in macrophages
2) Confidence 0.15 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9406876 Disease Relevance 1.22 Pain Relevance 0.73

General Comments

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